Distributed and Partially Separate Pools of Neurons Are Correlated with Two Different Components of the Gill-Withdrawal Reflex in Aplysia

We compared the spike activity of individual neurons in theAplysia abdominal ganglion with the movement of the gill during the gill-withdrawal reflex. We discriminated four populations that collectively encompass approximately half of the active neurons in the ganglion: (1) second-order sensory neurons that respond to the onset and offset of stimulation of the gill and are active before the movement starts; (2) neurons whose activity is correlated with the position of the gill and typically have a tonic output during gill withdrawal; (3) neurons whose activity is correlated with the velocity of the movement and typically fire in a phasic manner; and (4) neurons whose activity is correlated with both position and velocity. A reliable prediction of the position of the gill is achieved only with the combined output of 15–20 neurons, whereas a reliable prediction of the velocity depends on the combined output of 40 or more cells.