Possible environmental, occupational, and other etiologic factors for Parkinson's disease

In a case-control study, we investigated the possible etiologic relevance to Parkinson's disease (PD) of rural factors such as farming activity, pesticide exposures, well-water drinking, and animal contacts; toxicologic exposures such as wood preservatives, heavy metals, and solvents; general anesthesia; head trauma; and differences in the intrauterine environment. We recruited 380 patients in nine German clinics, 379 neighborhood control subjects, and 376 regional control subjects in the largest case-control study investigating such factors and collected data in structured personal interviews using conditional logistic regression to control for educational status and cigarette smoking. The latter was strongly inversely associated with PD. There were significantly elevated odds ratios (OR) for pesticide use, in particular, for organochlorines and alkylated phosphates, but no association was present between PD and other rural factors. A significantly elevated OR was present for exposure to wood preservatives. Subjective assessment by the probands indicated that exposure to some heavy metals, solvents, exhaust fumes, and carbon monoxide was significantly more frequent among patients than control subjects, but this was not confirmed by a parallel assessment of job histories according to a job exposure matrix. Patients had undergone general anesthesia and suffered severe head trauma more often than control subjects, but a dose-response gradient was not present. Patients reported a significantly larger number of amalgam-filled teeth before their illness than control subjects. The frequency of premature births and birth order did not differ between patients and control subjects. Patients reported significantly more relatives affected with PD than control subjects. These results support a role for environmental and genetic factors in the etiology of PD.

[1]  S. Kaveri,et al.  Immunomodulating effects of intravenous immunoglobulin in autoimmune and inflammatory diseases. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[2]  R. Haraldsdóttir Quality issues and nursing education. , 1994, European Quality Assurance Network newsletter.

[3]  L. Fleming,et al.  Parkinson's disease and brain levels of organochlorine pesticides , 1994, Annals of neurology.

[4]  D. Morens,et al.  Prospective study of cigarette smoking and the risk of developing idiopathic Parkinson's disease. , 1994, American journal of epidemiology.

[5]  R. Uitti,et al.  Parkinsonism induced by solvent abuse , 1994, Annals of neurology.

[6]  J. Konstankewecz Medical records and the IT revolution. , 1994, AMRO.

[7]  P. Jorens,et al.  Human Pentachlorophenol Poisoning , 1993, Human & experimental toxicology.

[8]  X M Cheng,et al.  A case-control study on the environmental risk factors of Parkinson's disease in Tianjin, China. , 1993, Neuroepidemiology.

[9]  J. Weiner,et al.  The relationship between mercury concentration in human organs and different predictor variables. , 1993, The Science of the total environment.

[10]  J. Fergusson,et al.  Concentrations and sources of cadmium, copper, lead and zinc in house dust in Christchurch, New Zealand. , 1993, The Science of the total environment.

[11]  J. Kurth,et al.  Association of a monoamine oxidase B allele with Parkinson's disease , 1993, Annals of neurology.

[12]  R. Penn,et al.  Neurosurgical horizons in Parkinson's disease , 1993, Neurology.

[13]  S. Fahn,et al.  The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it , 1992, Annals of neurology.

[14]  Richard S. J. Frackowiak,et al.  The identification of presymptomatic parkinsonism: Clinical and {18F}dopa positron emission tomography studies in an irish kindred , 1992, Annals of neurology.

[15]  J. Mcdonald,et al.  Organic brain damage and occupational solvent exposure. , 1992, British journal of industrial medicine.

[16]  A. E. Harding,et al.  Parkinson's disease in twins studied with 18F‐dopa and positron emission tomography , 1992, Neurology.

[17]  E. Love,et al.  Parkinson's disease and exposure to agricultural work and pesticide chemicals , 1992, Neurology.

[18]  B. Summers,et al.  Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease , 1992, The Lancet.

[19]  P. Vieregge,et al.  Life-style and Dietary Factors Early and Late in Parkinson’s Disease , 1992, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[20]  J. Idle,et al.  Mutant debrisoquine hydroxylation genes in Parkinson's disease , 1992, The Lancet.

[21]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[22]  P. K. Thomas,et al.  Diabetic Neuropathy: Models, Mechanisms and Mayhem , 1992, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[23]  Anthony Howell,et al.  Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group. , 1992 .

[24]  G. Rosati,et al.  Acute and persistent parkinsonism after use of diquat , 1992, Neurology.

[25]  M. Ron,et al.  Multiple sclerosis and the mind. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[26]  Lippincott Williams Wilkins,et al.  Assessment: Magnetoencephalography (MEG) , 1992 .

[27]  P. Jenner Oxidative stress as a cause of Parkinson's disease , 1991, Acta neurologica Scandinavica. Supplementum.

[28]  S. Gruber,et al.  The epidemiology of Parkinson's disease. A case-control study of young-onset and old-onset patients. , 1991, Archives of neurology.

[29]  E. Love,et al.  Parkinson's Disease and Exposure to Rural Environmental Factors: A Population Based Case-Control Study , 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[30]  Michel Gérin,et al.  Loss of Statistical Power Associated with the Use of a Job-Exposure Matrix in Occupational Case-Control Studies , 1991 .

[31]  W. Koller,et al.  Environmental risk factors in siblings with Parkinson's disease. , 1991, Archives of neurology.

[32]  J. Kurtzke,et al.  On the production of neurologists in the United States , 1991, Neurology.

[33]  N. Maizlish,et al.  Risk of neuropsychiatric disability among painters in the United States. , 1990, Scandinavian journal of work, environment & health.

[34]  L. Thal,et al.  The Lewy body variant of Alzheimer's disease , 1990, Neurology.

[35]  J Siemiatycki,et al.  Costs and statistical power associated with five methods of collecting occupation exposure information for population-based case-control studies. , 1989, American journal of epidemiology.

[36]  S. Ho,et al.  Epidemiologic study of Parkinson's disease in Hong Kong , 1989, Neurology.

[37]  C. Marsden,et al.  A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra , 1989, Journal of neurochemistry.

[38]  R. Waring,et al.  S-METHYLATION IN MOTORNEURON DISEASE AND PARKINSON'S DISEASE , 1989, The Lancet.

[39]  R. Waring,et al.  Xenobiotic metabolism in Parkinson's disease , 1989, Neurology.

[40]  M. Szklo,et al.  SHORTENING THE PUBLICATION LAG , 1989 .

[41]  C. Marsden,et al.  Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease , 1989, Journal of neurochemistry.

[42]  C H Ngim,et al.  Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson's disease. , 1989, Neuroepidemiology.

[43]  Peter Riederer,et al.  Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains , 1989, Journal of neurochemistry.

[44]  C. Marsden,et al.  Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease , 1989, Journal of neurochemistry.

[45]  N. Bornstein,et al.  Benign outcome of carotid occlusion , 1989, Neurology.

[46]  V. Gallo,et al.  Expression of Excitatory Amino Acid Receptors by Cerebellar Cells of the Type‐2 Astrocyte Cell Lineage , 1989, Journal of neurochemistry.

[47]  M J Aminoff,et al.  Evaluation of thermography in the diagnosis of selected entrapment neuropathies , 1989, Neurology.

[48]  M. Nylander,et al.  Correlation of dental amalgam with mercury in brain tissue. , 1987, The Journal of prosthetic dentistry.

[49]  R. Uitti,et al.  Familial Parkinson's Disease: Possible Role of Environmental Factors , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[50]  L. Kurland,et al.  A case‐control study of smoking habits, dementia, and other illnesses in idiopathic Parkinson's disease , 1987, Neurology.

[51]  T. B. Hart PARKINSON'S DISEASE AND PESTICIDES , 1987, The Lancet.

[52]  R. L. Rogers,et al.  Decreased cerebral blood flow precedes multi‐infarct dementia, but follows senile dementia of Alzheimer type , 1986, Neurology.

[53]  J. Poirier,et al.  ECOGENETICS OF PARKINSON'S DISEASE: 4-HYDROXYLATION OF DEBRISOQUINE , 1985, The Lancet.

[54]  W. Nicklas,et al.  Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. , 1985, Life sciences.

[55]  R. Eldridge,et al.  The low concordance rate for Parkinson's disease in twins , 1984, Neurology.

[56]  C. Ward,et al.  Parkinson's disease in 65 pairs of twins and in a set of quadruplets , 1983, Neurology.

[57]  J. Cramer,et al.  Principles in designing clinical trials for antiepileptic drugs , 1983, Neurology.

[58]  J. Langston,et al.  Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. , 1983, Science.

[59]  J. Ebersole,et al.  An evaluation of ambulatory, cassette EEG monitoring , 1983, Neurology.

[60]  R. Godwin-Austen,et al.  Smoking and Parkinson's disease. , 1982, Journal of neurology, neurosurgery, and psychiatry.

[61]  K. Fuxe,et al.  Toluene and telencephalic dopamine: selective reduction of amine turnover in discrete DA nerve terminal systems of the anterior caudate nucleus by low concentrations of toluene. , 1982, Toxicology letters.

[62]  Inamasu Takeo,et al.  Comparison of arsenic trioxide and calcium arsenate retention in the rat lung after intratracheal instillation. , 1982 .

[63]  J. Schlesselman,et al.  Case-Control Studies: Design, Conduct, Analysis , 1982 .

[64]  C. Hogstedt,et al.  Parkinson's disease and occupational exposure to organic solvents, agricultural chemicals and mercury--a case-referent study. , 1981, Scandinavian journal of work, environment & health.

[65]  R. Baumann,et al.  Nicotine exposure and Parkinson disease. , 1981, American journal of epidemiology.

[66]  A. Lilienfeld The humean fog: cancer and cholesterol. , 1981, American journal of epidemiology.

[67]  J. Brown Problems in evaluating new treatments for multiple sclerosis , 1980, Neurology.

[68]  E. Rogot,et al.  Smoking and causes of death among U.S. veterans: 16 years of observation. , 1980, Public health reports.

[69]  K. Back,et al.  Statistical Survey Techniques. , 1979 .

[70]  R. Doll,et al.  Mortality in relation to smoking: 20 years' observations on male British doctors. , 1976, British medical journal.

[71]  L. Kurland,et al.  Parkinson's disease. Genetic analysis and evidence of a multifactorial etiology. , 1973, Mayo Clinic proceedings.

[72]  I. I. Kessler,et al.  EPIDEMIOLOGIC STUDIES OF PARKINSON'S DISEASE: III. A COMMUNITY-BASED SURVEY , 1972 .

[73]  E. Diamond,et al.  Epidemiologic studies of Parkinson's disease. I. Smoking and Parkinson's disease: a survey and explanatory hypothesis. , 1971, American journal of epidemiology.

[74]  G. Comstock Fatal arteriosclerotic heart disease, water hardness at home, and socioeconomic characteristics. , 1971, American journal of epidemiology.

[75]  M. Nefzger,et al.  A retrospective study of smoking in Parkinson's disease. , 1968, American journal of epidemiology.

[76]  B. Modan An experiment in hospital epidemiology. , 1968, American journal of epidemiology.

[77]  P. Vieregge Genetic factors in the etiology of idiopathic Parkinson's disease , 1994, Journal of neural transmission. Parkinson's disease and dementia section.

[78]  J. Tayman Small area demographic forecasts. , 1994, Applied demography.

[79]  J. Potter,et al.  Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. , 1994, American journal of epidemiology.

[80]  S. B. Watson A legal challenge to the refusal to provide inappropriate treatment: the case of Baby K. , 1994, Clinical ethics report.

[81]  I. Kanazawa,et al.  Debrisoquine hydroxylase and Parkinson's disease. , 1993, Advances in neurology.

[82]  D. Hémon,et al.  Retrospective evaluation of occupational exposures in population-based case-control studies: general overview with special attention to job exposure matrices. , 1993, International journal of epidemiology.

[83]  W. Ahrens,et al.  Retrospective assessment of asbestos exposure--I. Case-control analysis in a study of lung cancer: efficiency of job-specific questionnaires and job exposure matrices. , 1993, International journal of epidemiology.

[84]  C. Marsden,et al.  Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease , 1992, Annals of neurology.

[85]  M Yasui,et al.  Calcium, magnesium and aluminum concentrations in Parkinson's disease. , 1992, Neurotoxicology.

[86]  F. Jiménez-Jiménez,et al.  Exposure to well water and pesticides in Parkinson's disease: A case‐control study in the madrid area , 1992, Movement disorders : official journal of the Movement Disorder Society.

[87]  S K Smith,et al.  An evaluation of population forecast errors for Florida and its counties. , 1992, Applied demography.

[88]  A. D. Schryver,et al.  Systemic treatment of early breast-cancer by hormonal, cytotoxic, or immune therapy: 133 randomized trials involving 31000 recurrences and 24000 deaths among 75000 women: 1 , 1992 .

[89]  W. Weiner,et al.  Prior history of head trauma in Parkinson's disease , 1991, Movement disorders : official journal of the Movement Disorder Society.

[90]  W. Gibb,et al.  Neuronal inclusions of Parkinson's disease , 1991, Movement disorders : official journal of the Movement Disorder Society.

[91]  C. Hertzman,et al.  Parkinson's disease: a case-control study of occupational and environmental risk factors. , 1990, American journal of industrial medicine.

[92]  L. Golbe,et al.  Follow‐up study of early‐life protective and risk factors in Parkinson's disease , 1990, Movement disorders : official journal of the Movement Disorder Society.

[93]  L. Heise Crimes of gender. , 1990, Women's health journal.

[94]  F. Sturmans,et al.  Exposure-outcome relationships between organic solvent exposure and neuropsychiatric disorders: results from a Dutch case-control study. , 1989, American journal of industrial medicine.

[95]  A. Hofman,et al.  Incidence and risk factors of Parkinson's disease in The Netherlands. , 1989, Neuroepidemiology.

[96]  A. Lilienfeld,et al.  Declining trends in mortality from cerebrovascular disease at ages 10-65 years: a test of validity. , 1989, Neuroepidemiology.

[97]  W. Weiner,et al.  Trauma as an etiology of parkinsonism: A historical review of the concept , 1988, Movement disorders : official journal of the Movement Disorder Society.

[98]  H Klausen,et al.  Chronic toxic encephalopathy in solvent-exposed painters in Denmark 1976-1980: clinical cases and social consequences after a 5-year follow-up. , 1987, American journal of industrial medicine.

[99]  A. Barbeau,et al.  Environmental and genetic factors in the etiology of Parkinson's disease. , 1987, Advances in neurology.

[100]  R. Uitti,et al.  Early onset Parkinson's disease and childhood environment. , 1987, Advances in neurology.

[101]  Steshenko Vs [On issues concerning the methodology of long-term population forecasting (a global aspect)]. , 1987 .

[102]  E. Somers International Agency for Research on Cancer. , 1985, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[103]  A. Delgado-Escueta,et al.  Type II complex partial seizures: poor results of anterior temporal lobectomy. , 1984, Neurology.

[104]  E. C. Hammond,et al.  Smoking in relation to the death rates of one million men and women. , 1966, National Cancer Institute monograph.

[105]  Kahn Ha The Dorn Study of Smoking and Mortality Among U.S. Veterans: Report on Eight and One-Half Years of Observation , 1966 .