Con: early extubation is not preferable to late extubation in patients undergoing coronary artery surgery.

T HERE HAS again arisen a trend to extubate patients within a few hours after cardiac surgery rather than continuing mechanica1 ventilation until the following morning.* Potential advantages of early termination of mechanical ventilation include shorter intensive care unit (ICU) stays, earlier patient mobilization, less lobar collapse and pneumonia, avoidance of endotracheal tube and ventilator malfunction, and decreased intrapleural pressures with resultant increased ventricular filling and improved cardiac output (CO). Surely this not only sounds reasonable, but appears to be a further advance in cardiac surgery. But is this technique appropriate for the patients who make up the cardiac surgery population in the 199Os? And, is this technique as benign as it seems when new biochemical, physiologic, hemodynamic, and ischemic data are considered that suggest that extubation during the early postoperative period might not be in the best interests of the patients?

[1]  W. Browner,et al.  Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group. , 1989, Anesthesiology.

[2]  D. Berman,et al.  Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. , 1988, The New England journal of medicine.

[3]  E. Jones,et al.  Coronary bypass surgery: is the operation different today? , 1991, The Journal of thoracic and cardiovascular surgery.

[4]  J. F. Dammann,et al.  The Cost of Respiratory Effort in Postoperative Cardiac Patients , 1963, Circulation.

[5]  G. Ronquist,et al.  Myocardial uptake of amino acids and other substrates in relation to myocardial oxygen consumption four hours after cardiac operations. , 1991, The Journal of thoracic and cardiovascular surgery.

[6]  G. Koski,et al.  Effect of Hypothermic Hemodilutional Cardiopulmonary Bypass on Plasma Sufentanil and Catecholamine Concentrations in Humans , 1988, Anesthesia and analgesia.

[7]  W. Browner,et al.  Postoperative Myocardial Ischemia: Therapeutic Trials Using Intensive Analgesia Following Surgery , 1992 .

[8]  W. Browner,et al.  Perioperative myocardial ischemia: importance of the preoperative ischemic pattern. , 1988 .

[9]  T. Gasior,et al.  Depression and recovery of right ventricular function after cardiopulmonary bypass. , 1990, Critical care medicine.

[10]  J. Takala,et al.  Hypermetabolism after coronary artery bypass. , 1991, The Journal of thoracic and cardiovascular surgery.

[11]  J. Tarnow,et al.  Isoflurane Improves the Tolerance to Pacing-induced Myocardial Ischemia , 1986 .

[12]  G. Smith,et al.  Halothane improves the balance of oxygen supply to demand in acute experimental myocardial ischaemia. , 1980, British journal of anaesthesia.

[13]  R. Okada,et al.  The Effect of Pulsatile Perfusion on Preservation of Left Ventricular Function After Aortocoronary Bypass Grafting , 1981, Circulation.

[14]  L. Smith,et al.  Influence of anesthesia on the threshold of pacing-induced ischemia. , 1992, Anesthesia and analgesia.

[15]  J. Halter,et al.  Mechanism of plasma catecholamine increases during surgical stress in man. , 1977, The Journal of clinical endocrinology and metabolism.

[16]  R C Smith,et al.  Postoperative myocardial ischemia in patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group. , 1991, Anesthesiology.

[17]  J. Mehta,et al.  Acute myocardial ischemia: role of atherosclerosis, thrombosis, platelet activation, coronary vasospasm, and altered arachidonic acid metabolism. , 1987, Circulation.

[18]  E. Lowenstein,et al.  Halothane‐induced Decrease in Experimental Myocardial Ischemia in the Non‐failing Canine Heart , 1976, Anesthesiology.

[19]  R. Lefkowitz,et al.  Interactions of Agonists with Platelet α2-Adrenergic Receptors , 1982 .

[20]  R. Thisted,et al.  IS INCREASED OPERATIVE STRESS ASSOCIATED WITH WORSE OUTCOME , 1987 .

[21]  C. Wilkinson,et al.  Serial assessment of left ventricular performance following coronary artery bypass grafting. Early postoperative results with myocardial protection afforded by multidose hypothermic potassium crystalloid cardioplegia. , 1981, The Journal of thoracic and cardiovascular surgery.

[22]  D. Ullyot,et al.  Postoperative respiratory care: a controlled trial of early and late extubation following coronary-artery bypass grafting. , 1980 .

[23]  R. Lanese,et al.  Morphine anesthesia blocks cortisol and growth hormone response to surgical stress in humans. , 1974, The Journal of clinical endocrinology and metabolism.

[24]  C. Hawkey,et al.  Stress—a significant factor in venous thrombosis? , 1974, British Journal of Surgery.

[25]  A. Keats,et al.  Does Perioperative Myocardial Ischemia Lead to Postoperative Myocardial Infarction? , 1985, Anesthesiology.

[26]  C. Aps,et al.  The management of cardiac surgical patients in a general surgical recovery ward. , 1989, Journal of Cardiovascular Surgery.

[27]  W. Browner,et al.  Association of Perioperative Myocardial Ischemia with Cardiac Morbidity and Mortality in Men Undergoing Noncardiac Surgery , 1990 .

[28]  J. Isern-Amaral,et al.  Urine Norepinephrine Excretion in Patients Undergoing Mitral or Aortic Valve Replacement with Morphine Anesthesia , 1975, Anesthesia and analgesia.

[29]  J. Reves,et al.  ISOFLURANE BLUNTS THE NOREPINEPHRINE RESPONSE TO CARDIOPULMONARY BYPASS , 1987 .

[30]  Warren S. Browner,et al.  Association of Perioperative Myocardial Ischemia with Cardiac Morbidity and Mortality in Men Undergoing Noncardiac Surgery , 1991 .

[31]  T. Stanley,et al.  Plasma Catecholamine and Cortisol Responses to Fentanyl–Oxygen Anesthesia for Coronary-artery Operations , 1980 .

[32]  J. Norton,et al.  Responses of the hypothalamic-pituitary-adrenal and renin-angiotensin axes and the sympathetic system during controlled surgical and anesthetic stress. , 1987, The Journal of clinical endocrinology and metabolism.

[33]  D. Mangano Biventricular Function after Myocardial Revascularization in Humans: Deterioration and Recovery Patterns during the First 24 Hours , 1985, Anesthesiology.

[34]  D. Berman,et al.  Scintigraphic and hemodynamic demonstration of transient left ventricular dysfunction immediately after uncomplicated coronary artery bypass grafting. , 1979, The Journal of thoracic and cardiovascular surgery.

[35]  J. Wernerman,et al.  Trauma metabolism and the heart: studies of heart and leg amino acid flux after cardiac surgery. , 1990, The Thoracic and cardiovascular surgeon.

[36]  G. P. Grabfield FACTORS AFFECTING THE COAGULATION TIME OF BLOOD: IX. The Effect of Adrenin on the Factors of Coagulation , 1916 .

[37]  A. Mansfield Alteration in Fibrinolysis Associated With Surgery and Venous Thrombosis , 1972, The British journal of surgery.

[38]  B. C. Bloor,et al.  Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery. , 1987 .

[39]  K. Anand,et al.  Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. , 1992, The New England journal of medicine.

[40]  Cass Principal Investigators and Their Associates Myocardial infarction and mortality in the coronary artery surgery study (CASS) randomized trial. , 1984, The New England journal of medicine.