Regenerative medicine and organ transplantation: past, present, and future.

This overview traces the history of regenerative medicine pertinent to organ transplantation, illustrates potential clinical applications reported to date, and highlights progress achieved in the field of complex modular organ engineering. Regenerative medicine can now produce relatively simple tissues such as skin, bladders, vessels, urethras, and upper airways, whereas engineering or generation of complex modular organs remains a major challenge. Ex vivo organ engineering may benefit from complementary investigations in the fields of developmental biology and stem cells and transplantation before its full potential can be realized.

[1]  G. Remuzzi,et al.  Kidney regeneration , 2010, The Lancet.

[2]  Y. Imai,et al.  Transplantation of a tissue-engineered pulmonary artery. , 2001, The New England journal of medicine.

[3]  T. McAllister,et al.  Tissue-engineered blood vessel for adult arterial revascularization. , 2007, The New England journal of medicine.

[4]  E Bell,et al.  Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Xu,et al.  [Preparation of whole-kidney acellular matrix in rats by perfusion]. , 2009, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[6]  T. Starzl,et al.  Clinical Trials and Projected Future of Liver Xenotransplantation , 1997, World Journal of Surgery.

[7]  R. Alloway,et al.  Composite tissue allotransplantation: a review of relevant immunological issues for plastic surgeons. , 2008, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[8]  S. Curley.  Radiofrequency ablation leads to excellent local tumor control and durable longterm survival in specific subsets of early stage HCC patients confirming to the Milan criteria. , 2010, Annals of surgery.

[9]  Charles A. Vacanti,et al.  Transplantation of Chondrocytes Utilizing a Polymer‐Cell Construct to Produce Tissue‐Engineered Cartilage in the Shape of a Human Ear , 1997, Plastic and reconstructive surgery.

[10]  Serghei Cebotari,et al.  Guided tissue regeneration: porcine matrix does not transmit PERV. , 2004, Biomaterials.

[11]  Robert M Nerem,et al.  Progress in tissue engineering and regenerative medicine , 2010, Proceedings of the National Academy of Sciences.

[12]  L. Bailey,et al.  Baboon-to-human cardiac xenotransplantation in a neonate. , 1985, JAMA.

[13]  James J. Yoo,et al.  Tissue-engineered autologous urethras for patients who need reconstruction: an observational study , 2011, The Lancet.

[14]  H. Mertsching,et al.  Generation and Transplantation of an Autologous Vascularized Bioartificial Human Tissue , 2009, Transplantation.

[15]  A. Sirigu,et al.  Outcomes 18 months after the first human partial face transplantation. , 2007, The New England journal of medicine.

[16]  G. Naughton,et al.  The Advanced Tissue Sciences story. , 1999, Scientific American.

[17]  J. Till,et al.  Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells , 1963, Nature.

[18]  Matthew D. Kwan,et al.  Regenerative medicine: the next frontier. , 2008, Transplantation.

[19]  J. Dausset.  Iso-leuco-anticorps , 1958 .

[20]  A. Ylppo.  Children's Clinic, Helsinki. , 1948, Lancet.

[21]  Marcin Maruszewski,et al.  Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study , 2009, The Lancet.

[22]  James J. Yoo,et al.  Tissue-engineered autologous bladders for patients needing cystoplasty , 2006, The Lancet.

[23]  P. Macchiarini,et al.  Tissue-Engineered Tracheal Transplantation , 2010, Transplantation.

[24]  P. Bourin,et al.  Mesenchymal Stem Cells for Therapeutic Purposes , 2009, Transplantation.

[25]  Naohiro Terada,et al.  Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds. , 2009, Journal of the American Society of Nephrology : JASN.

[26]  N. Parenteau,et al.  Skin: the first tissue-engineered products. , 1999, Scientific American.

[27]  I. Wilmut,et al.  Viable offspring derived from fetal and adult mammalian cells , 1997, Nature.

[28]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[29]  Paul Kemp,et al.  History of regenerative medicine: looking backwards to move forwards. , 2006, Regenerative medicine.

[30]  Karina H Nakayama,et al.  Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. , 2010, Tissue engineering. Part A.

[31]  N. Perico,et al.  Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group , 2009, Transplantation.

[32]  Sara Mantero,et al.  Clinical transplantation of a tissue-engineered airway , 2008, The Lancet.

[33]  Anthony Atala,et al.  Engineering organs. , 2009, Current opinion in biotechnology.

[34]  N. L'Heureux,et al.  Human tissue-engineered blood vessels for adult arterial revascularization , 2007, Nature Medicine.

[35]  S. Soker,et al.  Clinical Operational Tolerance After Renal Transplantation: Current Status and Future Challenges , 2010, Annals of surgery.

[36]  P. Hervé.  Donor-derived hematopoietic stem cells in organ transplantation: technical aspects and hurdles yet to be cleared , 2003, Transplantation.

[37]  Paolo De Coppi,et al.  Regenerative medicine as applied to solid organ transplantation: current status and future challenges , 2011, Transplant international : official journal of the European Society for Organ Transplantation.

[38]  J. Vacanti,et al.  Beyond transplantation. Third annual Samuel Jason Mixter lecture. , 1988, Archives of surgery.

[39]  H. Mertsching,et al.  In vivo model for cross-species porcine endogenous retrovirus transmission using tissue engineered pulmonary arteries. , 2003, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[40]  R. Hewitt,et al.  RENAL HETEROTRANSPLANTATION IN MAN. , 1964, Annals of surgery.

[41]  S. Nigam,et al.  Developmental approaches to kidney tissue engineering. , 2004, American journal of physiology. Renal physiology.

[42]  Anthony Atala,et al.  Whole organ decellularization - a tool for bioscaffold fabrication and organ bioengineering , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[43]  J. Mulliken,et al.  GRAFTING OF BURNS WITH CULTURED EPITHELIUM PREPARED FROM AUTOLOGOUS EPIDERMAL CELLS , 1981, The Lancet.

[44]  P. Macchiarini,et al.  Airway Transplantation: A Debate Worth Having? , 2008, Transplantation.

[45]  Anthony Atala,et al.  Identification and characterization of bioactive factors in bladder submucosa matrix. , 2007, Biomaterials.

[46]  D. Ingber,et al.  Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.

[47]  Christian Schuetz,et al.  Regeneration and orthotopic transplantation of a bioartificial lung , 2010, Nature Medicine.

[48]  P. Clavien,et al.  Alexis Carrel: Genius, Innovator and Ideologist , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[49]  C. Grandi,et al.  Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: in vitro and in vivo studies. , 2009, International journal of molecular medicine.

[50]  J. Murray.  The first successful organ transplants in man. , 2005, Journal of the American College of Surgeons.

[51]  Joseph Vacanti,et al.  Tissue engineering and regenerative medicine: from first principles to state of the art. , 2010, Journal of pediatric surgery.

[52]  C. Mason,et al.  A brief definition of regenerative medicine. , 2008, Regenerative medicine.

[53]  Zhen W. Zhuang,et al.  Tissue-Engineered Lungs for in Vivo Implantation , 2010, Science.

[54]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[55]  C. Legendre,et al.  Clinical Operational Tolerance after Kidney Transplantation , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[56]  S. Willadsen,et al.  Nuclear transplantation in sheep embryos , 1986, Nature.

[57]  D. Gerber,et al.  The Future of Cell Transplant Therapies: A Need for Tissue Grafting , 2010, Transplantation.

[58]  S. Soker,et al.  Operational tolerance after liver transplantation. , 2009, Journal of hepatology.

[59]  Doris A Taylor,et al.  Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart , 2008, Nature Medicine.

[60]  I. Wilmut,et al.  "Viable Offspring Derived from Fetal and Adult Mammalian Cells" (1997), by Ian Wilmut et al. , 2014 .

[61]  S Louise Moffatt,et al.  Centennial review of corneal transplantation , 2005, Clinical & experimental ophthalmology.

[62]  Hiroshi Yagi,et al.  Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix , 2010, Nature Medicine.

[63]  G. Martin,et al.  Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[64]  S. Badylak,et al.  Introduction: History of Regenerative Medicine , 2009 .

[65]  R Langer,et al.  Selective cell transplantation using bioabsorbable artificial polymers as matrices. , 1988, Journal of pediatric surgery.

[66]  S. Willadsen,et al.  A simple procedure for the production of identical sheep twins , 1984, Veterinary Record.

[67]  E. Thomas,et al.  Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. , 1957, The New England journal of medicine.

[68]  Pedro M. Baptista,et al.  The use of whole organ decellularization for the generation of a vascularized liver organoid , 2011, Hepatology.

[69]  N. Perico,et al.  Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). , 2010, Transplantation.

[70]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[71]  JOHN F. BURKE,et al.  Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn Injury , 1981, Annals of surgery.

[72]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[73]  Kerry A. Daly,et al.  Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. , 2009, Tissue engineering. Part A.