Effect of increased concentrations of carbon dioxide during halothane anaesthesia on liver blood flow and hepatic oxygen consumption.

The effects of hypercapnia (during halothane anaesthesia) on the hepatic circulation and hepatic oxygen consumption were investigated in anaesthetized greyhounds. The administration of 1% halothane alone caused significant decreases in both hepatic arterial and portal venous blood flows. Hepatic oxygen consumption did not change significantly. When carbon dioxide was added to the inspired gas mixture during the continued administration of halothane, hepatic arterial blood flow showed a further decrease (P less than 0.01), while portal venous flow increased markedly. This resulted in an overall increase in total liver blood flow. Hepatic oxygen supply increased also. However, hepatic oxygen consumption increased during the periods of hypercapnia. Thus, although the hypercapnia increased the oxygen supply to the liver, there was no improvement in the supply: demand ratio.

[1]  E. D. Jacobson,et al.  Physiology of the splanchnic circulation. , 1985, Archives of internal medicine.

[2]  R. Hughes,et al.  Effects of nitrous oxide on liver haemodynamics and oxygen consumption in the greyhound , 1982, Anaesthesia.

[3]  R. Hughes,et al.  Effects of enflurane and halothane on liver blood flow and oxygen consumption in the greyhound. , 1980, British journal of anaesthesia.

[4]  R. Hughes,et al.  Effect of hypercarbia on hepatic blood flow and oxygen consumption in the greyhound. , 1979, British journal of anaesthesia.

[5]  J. McGrath,et al.  SYMPATHOMIMETIC EFFECTS OF PANCURONIUM BROMIDE ON THE CARDIOVASCULAR SYSTEM OF THE PITHED RAT: A COMPARISON WITH THE EFFECTS OF DRUGS BLOCKING THE NEURONAL UPTAKE OF NORADRENALINE , 1978, British journal of pharmacology.

[6]  L. Irestedt,et al.  The Different Responses of the Hepatic Arterial Bed to Hypovolaemia and to Halothane Anaesthesia , 1977, Acta anaesthesiologica Scandinavica.

[7]  N. Einer-jensen,et al.  The Effect on the Splanchnic Blood Flow and Cardiac Output of Various Carbon Dioxide Concentrations during Fluroxene (Fluoromar®) Anaesthesia An Animal Study , 1977, Acta anaesthesiologica Scandinavica.

[8]  I. Sipes,et al.  Bioactivation and covalent binding of halothane to liver macromolecules. , 1977, Environmental health perspectives.

[9]  J. Oroz,et al.  Pancuronium bromide: an indirect sympathomimetic agent. , 1976, British journal of anaesthesia.

[10]  M. Levitzky,et al.  Carbon dioxide and liver blood flow. , 1976, Bulletin europeen de physiopathologie respiratoire.

[11]  N. Einer-jensen,et al.  Hepatic Blood Flow and Cardiac Output During Halothane Anesthesia: An Animal Study , 1974, Acta anaesthesiologica Scandinavica.

[12]  W. Mapleson,et al.  Determination of halothane in gas, blood, and tissues by chemical extraction and gas chromatography. , 1971, British Journal of Anaesthesia.

[13]  I. Bonta,et al.  Mechanism of selective cardiac vagolytic action of pancuronium bromide. Specific blockade of cardiac muscarinic receptors. , 1970, European journal of pharmacology.

[14]  U. Peiper,et al.  [Appearance and size of veno-vasomotor reactions in liver circulation]. , 1968, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere.

[15]  S. Deutsch.  Physiology of the splanchnic circulation and its alteration by general anesthesia and hemorrhage in man. , 1967, American journal of surgery.

[16]  A. Fajgelj,et al.  Hepatic Blood Flow During Different Depths of Halothane Anaesthesia in the Dog , 1967, Acta anaesthesiologica Scandinavica.

[17]  P. Johnson,et al.  Local control of hepatic arterial and portal venous flow in the dog. , 1966, The American journal of physiology.

[18]  J. P. Gilmore.  PENTOBARBITAL SODIUM ANESTHESIA IN THE DOG. , 1965, The American journal of physiology.

[19]  R. Cohn,et al.  FACTORS INFLUENCING CONTROL OF ARTERIAL CIRCULATION IN THE LIVER OF THE DOG. , 1963, The American journal of physiology.

[20]  H. O. Wheeler,et al.  THE EFFECT OF HYPERCAPNIA ON ESTIMATED HEPATIC BLOOD FLOW, CIRCULATING SPLANCHNIC BLOOD VOLUME AND HEPATIC SULFOBROMOPHTHALEIN CLEARANCE DURING GENERAL ANESTHESIA IN MAN , 1961, Journal of Clinical Investigation.

[21]  E. Brown,et al.  Mechanism of splenic contraction produced by severe hypercapnia. , 1959, American Journal of Physiology.

[22]  S. Horvath,et al.  Influence of sodium pentobarbital on splanchnic blood flow and related functions. , 1959, The American journal of physiology.

[23]  J. P. Gilmore.  Effect of anesthesia and hepatic sampling site upon hepatic blood flow. , 1958, The American journal of physiology.

[24]  R. Selker,et al.  Observations on liver blood flow; its relationship to cardiac output in anesthetized and unanesthetized animals. , 1956, A.M.A. archives of surgery.

[25]  Russell Burton-Opitz,et al.  THE VASCULARITY OF THE LIVER. II. THE INFLUENCE OF THE PORTAL BLOOD‐FLOW UPON THE FLOW IN THE HEPATIC ARTERY , 1911 .

[26]  R. Burton-Opitz.  THE VASCULARITY OF THE LIVER. IV. THE MAGNITUDE OF THE PORTAL INFLOW , 1911 .