Assessing BCG vaccination coverage and incidence of paediatric tuberculosis following two major changes in BCG vaccination policy in France.

We report data on BCG vaccination coverage and paediatric tuberculosis (TB) incidence collected after the disappearance of the multipuncture device for BCG vaccination in January 2006 and the shift from universal to targeted vaccination in July 2007 in France.Vaccination coverage estimates in children for whom BCG is recommended allow assessing whether the recommendations are followed by doctors and/or accepted by the target population. In January and February 2006, BCG sales to the private sector in Îlede-France region were 74.2% and 41.3% of the ones for the same months the previous year. Total sales in 2006 amounted to 57.3% of those in 2005. Coverage decreased immediately after withdrawal of the multipuncture device, and remained generally insufficient in high risk children in the following years. However,the impact on paediatric TB incidence in 2008 seems very limited, although the duration of follow-up is still short. Training of doctors in intra-dermal vaccination and communication on the new vaccination policy should be strengthened

[1]  Addendum A L’AVIS Haut Conseil de la santé publique , 2011 .

[2]  J. Guthmann,et al.  Couverture vaccinale BCG chez les enfants nés après la suspension de l'obligation vaccinale et suivis dans les PMI de France: enquête nationale 2009 , 2010 .

[3]  D. Che,et al.  Epidemiology of tuberculosis in France: cases reported in 2008. , 2010 .

[4]  D. Levy-bruhl,et al.  Vaccination coverage estimated based on data found in 24th month health certificates of infants, France, 2004-2007. , 2010 .

[5]  D. Levy-bruhl,et al.  [BCG vaccination coverage in children born after the end of compulsory BCG vaccination and followed in maternal and child health clinics in France: a national survey 2009]. , 2010, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[6]  D. Levy-bruhl,et al.  [BCG vaccine coverage in private medical practice: First data in children below two years old, seven months after the end of compulsory vaccination in France]. , 2009, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[7]  Z. Jakab Tuberculosis in the European Union: ongoing commitment needed to control the disease. , 2009, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[8]  D. Che,et al.  Tuberculosis cases notified in France in 2007. , 2009 .

[9]  D. Levy-bruhl,et al.  BCG vaccination coverage and epidemiology of tuberculosis in children: where do we stand one year after suspending mandatory immunization, in France? , 2009 .

[10]  C. Manaouil,et al.  Comment en est-on arrivé à suspendre l’obligation vaccinale du BCG ? , 2008 .

[11]  J. Giesecke,et al.  Assessing the impact of different BCG vaccination strategies on severe childhood TB in low-intermediate prevalence settings. , 2008, Vaccine.

[12]  M. Gignon,et al.  [Tuberculosis vaccination programs: where are we?]. , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[13]  D. Antoine,et al.  Recent changes in tuberculosis control and BCG vaccination policy in France. , 2007, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[14]  D. Levy-bruhl Prospects for the BCG vaccination programme in France. , 2006, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[15]  J. Watson Tuberculosis and BCG in Europe. , 2006, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[16]  R. Cohen,et al.  Enquête sur les pratiques actuelles et futures du vaccin contre la tuberculose auprès des pédiatres et généralistes en France , 2005 .

[17]  D. Lévy-Bruhl Estimation de l’impact épidémiologique de différentes options de vaccination BCG en France , 2005 .

[18]  D. Levy-bruhl [Estimation of the epidemiological impact of various BCG vaccination scenarios in France]. , 2005, Revue d'epidemiologie et de sante publique.

[19]  R. Cohen,et al.  [French paediatrician and general practitioner's survey about actual and future BCG use]. , 2005, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[20]  BCG vaccine. WHO position paper. , 2004, Releve epidemiologique hebdomadaire.

[21]  Criteria for discontinuation of vaccination programmes using Bacille Calmette-Guerin (BCG) in countries with a low prevalence of tuberculosis. A statement of the International Union Against Tuberculosis and Lung Disease. , 1994, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[22]  H. Hallander,et al.  The impact of changing BCG coverage on tuberculosis incidence in Swedish-born children between 1969 and 1989. , 1992, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[23]  V. Romanus First experience with BCG discontinuation in Europe. Experience in Sweden 15 years after stopping general BCG vaccination at birth. , 1990, Bulletin of the International Union against Tuberculosis and Lung Disease.