Fibre optic ATR-IR spectroscopy at cryogenic temperatures: in-line reaction monitoring on organolithium compounds.

A reliable methodology, utilising an ATR-IR fibre probe, for in-line monitoring of low temperature reactions is presented. The application of this convenient set-up enables a fast and safe exploration of highly reactive substrates. Hence, in situ monitoring of lithiation reactions is realised and the potential to investigate sensitive intermediates is being demonstrated.

[1]  B. Lendl,et al.  Convenient multigram synthesis of monodisperse oligo(ethylene glycols): effective reaction monitoring by infrared spectroscopy using an attenuated total reflection fibre optic probe , 2009 .

[2]  W. Bailey,et al.  Optimization of Organolithium Reactions , 2009 .

[3]  K. Singh,et al.  Lithium diisopropylamide-mediated ortholithiations: lithium chloride catalysis. , 2009, The Journal of organic chemistry.

[4]  C. Hametner,et al.  Selective halogen dance reactions at 5,5'-dibromo-2,2'-bithiophene , 2008 .

[5]  Qiang Zhao,et al.  A Series of Red‐Light‐Emitting Ionic Iridium Complexes: Structures, Excited State Properties, and Application in Electroluminescent Devices , 2008 .

[6]  Ji-Hoon Lee,et al.  Synthesis and electroluminescence properties of novel deep blue emitting 6,12-dihydro-diindeno[1,2-b;1',2'-e]pyrazine derivatives. , 2008, Chemical communications.

[7]  AtherFarooq Khan,et al.  Halogen dance reactions--a review. , 2007, Chemical Society Reviews.

[8]  Marcus V. N. Souza.  Halogen Dance Reaction and Its Application in Organic Synthesis , 2007 .

[9]  W. Leitner,et al.  Highly Flexible Fibre-Optic ATR-IR Probe for Inline Reaction Monitoring , 2007 .

[10]  L. Küpper,et al.  Mid‐Infrared Monitoring of Gas‐Liquid Reactions in Vitamin D Analogue Synthesis with a Novel Fiber Optical Diamond ATR Sensor , 2006 .

[11]  Mingsheng Huang,et al.  Organolithium reagents in pharmaceutical asymmetric processes. , 2006, Chemical reviews.

[12]  Srinivas Tummala,et al.  Emerging technologies supporting chemical process R&D and their increasing impact on productivity in the pharmaceutical industry. , 2006, Chemical reviews.

[13]  F. Mongin,et al.  On the deprotonation of 3,5-dichloropyridine using lithium bases: in situ infrared spectroscopic studies , 2005 .

[14]  Romà Tauler,et al.  A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB , 2005 .

[15]  M. Schlosser.  The 2 x 3 toolbox of organometallic methods for regiochemically exhaustive functionalization. , 2005, Angewandte Chemie.

[16]  H. Heise,et al.  Novel infrared optical probes for process monitoring and analysis based on next-generation silver halide fibers , 2003, Analytical and bioanalytical chemistry.

[17]  L. Que,et al.  Biomimetic aryl hydroxylation derived from alkyl hydroperoxide at a nonheme iron center. Evidence for an Fe(IV)=O oxidant. , 2003, Journal of the American Chemical Society.

[18]  J. Fröhlich.  Substituted Heterocyclic Compounds by Selective Control of Halogen-Dance Reactions , 1994 .

[19]  T. Smyth,et al.  Rapid injection NMR: A simple technique for the observation of reactive intermediates , 1981 .

[20]  W. Schlenk,et al.  Über die einfachsten metallorganischen Alkaliverbindungen , 1917 .