Genome Editing
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[1] J. O'neil,et al. Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo , 2013, Stem cells.
[2] Hao Yin,et al. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype , 2014, Nature Biotechnology.
[3] E. Maestrini,et al. A novel X-linked gene, G4.5. is responsible for Barth syndrome , 1996, Nature Genetics.
[4] Yanpeng Wang,et al. Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew , 2014, Nature Biotechnology.
[5] Alexander Pertsemlidis,et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 , 2005, Nature Genetics.
[6] Danwei Huangfu,et al. Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. , 2016, Cell stem cell.
[7] Simone Hahn,et al. Plant Pathogen Recognition Mediated by Promoter Activation of the Pepper Bs3 Resistance Gene , 2007, Science.
[8] Max A. Horlbeck,et al. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation , 2014, Cell.
[9] David J. Anderson,et al. Notch signalling controls pancreatic cell differentiation , 1999, Nature.
[10] Takashi Yamamoto,et al. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice , 2015, Genome Biology.
[11] R. Kanaar,et al. DNA double-strand break repair: all's well that ends well. , 2006, Annual review of genetics.
[12] Wei Yan,et al. Production of Gene‐Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation , 2015, Stem cells.
[13] S. Kouhpayeh,et al. Zinc Finger Nuclease: A New Approach to Overcome Beta-Lactam Antibiotic Resistance , 2016, Jundishapur journal of microbiology.
[14] F. Gleason,et al. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA , 2014 .
[15] R. Harvey,et al. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. , 1996, Development.
[16] H. Watkins,et al. Genetic Cardiomyopathies Causing Heart Failure , 2013, Circulation research.
[17] Kang Zhang,et al. Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. , 2014, Journal of genetics and genomics = Yi chuan xue bao.
[18] P. Sanders,et al. Expression of bacterial genes in plant cells. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[19] Yinhua Lu,et al. One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces. , 2015, Acta biochimica et biophysica Sinica.
[20] J. Doudna,et al. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , 2012, Science.
[21] T. Opriessnig,et al. Edinburgh Research Explorer Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection , 2018 .
[22] A. Bang,et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells , 2011, Nature Biotechnology.
[23] T. Kamp. Recognizing heart cells in a crowd , 2011, Nature Methods.
[24] Ramsong Chantre Nongpiur,et al. Genomics Approaches For Improving Salinity Stress Tolerance in Crop Plants , 2016, Current genomics.
[25] Ewelina Bolcun-Filas,et al. A Mouse Geneticist’s Practical Guide to CRISPR Applications , 2014, Genetics.
[26] Jens Boch,et al. Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors , 2009, Science.
[27] Samuel Bernard,et al. Evidence for Cardiomyocyte Renewal in Humans , 2008, Science.
[28] Robert Passier,et al. Concise Review: Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity , 2016, Stem cells.
[29] Randall J. Platt,et al. Therapeutic genome editing: prospects and challenges , 2015, Nature Medicine.
[30] H. Schöler,et al. Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 , 1998, Cell.
[31] William H. Majoros,et al. Multiplex CRISPR/Cas9-Based Genome Editing for Correction of Dystrophin Mutations that Cause Duchenne Muscular Dystrophy , 2015, Nature Communications.
[32] J. Renard,et al. Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. , 1997, Development.
[33] Danwei Huangfu,et al. A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells , 2015, Stem cell reports.
[34] T. Mashimo,et al. Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR–Cas platform , 2014, Nature Communications.
[35] I. Hardcastle,et al. 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK). , 2003, Bioorganic & medicinal chemistry letters.
[36] Luke A. Gilbert,et al. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression , 2013, Cell.
[37] A. Hattersley,et al. Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3 , 2011, Diabetes.
[38] D. Srivastava,et al. Mutations in NOTCH1 cause aortic valve disease , 2005, Nature.
[39] David Baker,et al. megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering , 2013, Nucleic acids research.
[40] E. Kroon,et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.
[41] Dana Carroll,et al. Enhancing Gene Targeting with Designed Zinc Finger Nucleases , 2003, Science.
[42] Jennifer Nichols,et al. A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages , 2013, Nature Cell Biology.
[43] P. Rouet,et al. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. , 1994, Molecular and cellular biology.
[44] Steven Lin,et al. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery , 2014, eLife.
[45] P. Duchateau,et al. A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences , 2006, Nucleic acids research.
[46] Jian-Kang Zhu,et al. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks , 2011, Proceedings of the National Academy of Sciences.
[47] R. Prather,et al. Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus , 2016, Nature Biotechnology.
[48] Y. Fischer,et al. NANOG Reporter Cell Lines Generated by Gene Targeting in Human Embryonic Stem Cells , 2010, PloS one.
[49] W. Heyer,et al. Regulation of homologous recombination in eukaryotes. , 2010, Annual review of genetics.
[50] D. Lu,et al. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells , 2013, Nucleic acids research.
[51] Matthew J. Moscou,et al. A Simple Cipher Governs DNA Recognition by TAL Effectors , 2009, Science.
[52] L. Sussel,et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. , 2000, Development.
[53] Kai Rothkamm,et al. Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle , 2003, Molecular and Cellular Biology.
[54] W. Clarke,et al. Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 , 1997, Nature Genetics.
[55] D. Barnes. Non-homologous end joining as a mechanism of DNA repair , 2001, Current Biology.
[56] S. Chandrasegaran,et al. Custom-designed zinc finger nucleases: What is next? , 2007, Cellular and Molecular Life Sciences.
[57] W. Cui,et al. Stably Transfected Human Embryonic Stem Cell Clones Express OCT4‐Specific Green Fluorescent Protein and Maintain Self‐Renewal and Pluripotency , 2005, Stem cells.
[58] Aaron M Zorn,et al. Vertebrate endoderm development and organ formation. , 2009, Annual review of cell and developmental biology.
[59] A. Colman,et al. Highly enriched cardiomyocytes from human embryonic stem cells. , 2008, Cytotherapy.
[60] D. Melton,et al. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. , 2002, Development.
[61] J. Orange,et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases , 2008, Nature Biotechnology.
[62] Masafumi Mikami,et al. CRISPR/Cas9-mediated mutagenesis of the RIN locus that regulates tomato fruit ripening. , 2015, Biochemical and biophysical research communications.
[63] Hidde L Ploegh,et al. Inhibition of non-homologous end joining increases the efficiency of CRISPR/Cas9-mediated precise [TM: inserted] genome editing , 2015, Nature Biotechnology.
[64] Sheng Huang,et al. TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain , 2010, Nucleic Acids Res..
[65] F. Gage,et al. Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. , 2015, Cell reports.
[66] J. Karn,et al. Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing , 2015, Scientific Reports.
[67] Le Cong,et al. Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.
[68] Tetsushi Sakuma,et al. Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9 , 2014, Stem cell reports.
[69] TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants , 2013, Plant Molecular Biology.
[70] Simona Casini,et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome , 2013, The EMBO journal.
[71] S Chandrasegaran,et al. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[72] R. Barrangou,et al. CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes , 2007, Science.
[73] Erin L. Doyle,et al. Targeting DNA Double-Strand Breaks with TAL Effector Nucleases , 2010, Genetics.
[74] Seung Woo Cho,et al. Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly. , 2009, Genome research.
[75] Yong Wang,et al. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 , 2017, Science.
[76] M. Helmrath,et al. The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas , 2015, Diabetes.
[77] C. Barbas,et al. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. , 2013, Trends in biotechnology.
[78] Philippe Horvath,et al. The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli , 2011, Nucleic acids research.
[79] K. Pollard,et al. Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency , 2015, Cell.
[80] Jonathan C. Cohen,et al. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. , 2006, American journal of human genetics.
[81] Wei Tang,et al. Correction of a genetic disease in mouse via use of CRISPR-Cas9. , 2013, Cell stem cell.
[82] Christopher M. Vockley,et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors , 2013, Nature Methods.
[83] Pei-Rong Wang,et al. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. , 2011, Cell stem cell.
[84] Yoshitaka Fujihara,et al. Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA , 2013, Scientific Reports.
[85] G. Church,et al. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. , 2011, Nature biotechnology.
[86] T. Sonstegard,et al. Production of hornless dairy cattle from genome-edited cell lines , 2016, Nature Biotechnology.
[87] Chad W. Euler,et al. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials , 2014, Nature Biotechnology.
[88] Duhee Bang,et al. A library of TAL effector nucleases spanning the human genome , 2013, Nature Biotechnology.
[89] Jan-Peter van Pijkeren,et al. CRISPR–Cas9-assisted recombineering in Lactobacillus reuteri , 2014, Nucleic acids research.
[90] T. Shindo,et al. A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice , 2014, BMC Biotechnology.
[91] J. Weissenbach,et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia , 2003, Nature Genetics.
[92] S. Ehrlich,et al. Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin. , 2005, Microbiology.
[93] Rudolf Jaenisch,et al. One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering , 2013, Cell.
[94] M. Spalding,et al. High-efficiency TALEN-based gene editing produces disease-resistant rice , 2012, Nature Biotechnology.
[95] A. De,et al. An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression , 2012, Cell.
[96] A. McCulloch,et al. Lentiviral Vectors and Protocols for Creation of Stable hESC Lines for Fluorescent Tracking and Drug Resistance Selection of Cardiomyocytes , 2009, PloS one.
[97] Ronnie J Winfrey,et al. High frequency modification of plant genes using engineered zinc finger nucleases , 2009, Nature.
[98] Takashi Yamamoto,et al. Simple knockout by electroporation of engineered endonucleases into intact rat embryos , 2014, Scientific Reports.
[99] Ho Won Kim,et al. Low‐Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells , 2015, Stem cells translational medicine.
[100] David A. Brafman,et al. Analysis of SOX2-Expressing Cell Populations Derived from Human Pluripotent Stem Cells , 2013, Stem cell reports.
[101] Y. Doyon,et al. Precise genome modification in the crop species Zea mays using zinc-finger nucleases , 2009, Nature.
[102] James A. Thomson,et al. Homologous recombination in human embryonic stem cells , 2003, Nature Biotechnology.
[103] M. Bétermier,et al. Is Non-Homologous End-Joining Really an Inherently Error-Prone Process? , 2014, PLoS genetics.
[104] G. Warnock,et al. Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice , 2012, Diabetes.
[105] G. Schmitz,et al. Cleavage of yeast and bacteriophage T7 genomes at a single site using the rare cutter endonuclease I-Sce I , 1991, Nucleic Acids Res..
[106] W. Arber. Host-Controlled Modification of Bacteriophage , 1965 .
[107] S. Hughes,et al. Altering the Genome by Homologous Recombination , 2010 .
[108] R. Jaenisch,et al. One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering , 2013, Cell.
[109] T. Sonstegard,et al. Precision Animal Breeding as a Sustainable , non-GMO Solution for Improving Animal Production and Welfare , 2016 .
[110] Hans Clevers,et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. , 2013, Cell stem cell.
[111] Feng Zhang,et al. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system , 2013, Nucleic acids research.
[112] D. F. Carlson,et al. Efficient nonmeiotic allele introgression in livestock using custom endonucleases , 2013, Proceedings of the National Academy of Sciences.
[113] Lia Crotti,et al. Long-QT syndrome: from genetics to management. , 2012, Circulation. Arrhythmia and electrophysiology.
[114] Yong Fan,et al. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. , 2014, Stem cells and development.
[115] E. Rebar,et al. Genome editing with engineered zinc finger nucleases , 2010, Nature Reviews Genetics.
[116] Yunde Zhao,et al. Engineering Herbicide-Resistant Rice Plants through CRISPR/Cas9-Mediated Homologous Recombination of Acetolactate Synthase. , 2016, Molecular plant.
[117] Meiru Li,et al. Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System , 2016, Front. Plant Sci..
[118] L. Ptaszek,et al. New tools for genome modification in human embryonic stem cells. , 2007, Cell stem cell.
[119] Jun Qiao,et al. Efficient Gene Knockout in Goats Using CRISPR/Cas9 System , 2014, PloS one.
[120] Lei S. Qi,et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. , 2015, Cell stem cell.
[121] Shinya Yamanaka,et al. Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches. , 2015, Cell stem cell.
[122] Daniel J. Rader,et al. Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing , 2014, Circulation research.
[123] Y. Liu,et al. Creation of Engineered Human Embryonic Stem Cell Lines Using phiC31 Integrase , 2008, Stem cells.
[124] S. Ha,et al. Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases , 2014, Genome research.
[125] A Klug,et al. Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes. , 1985, The EMBO journal.
[126] Seung Woo Cho,et al. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease , 2013, Nature Biotechnology.
[127] William L. Clarke,et al. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence , 1997, Nature Genetics.
[128] Yoshitaka Fujihara,et al. Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes , 2014, Development, growth & differentiation.
[129] Chad A. Cowan,et al. Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. , 2014, Cell stem cell.
[130] T. Cathomen,et al. The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. , 2013, Human gene therapy.
[131] Timothy K Lu,et al. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases , 2014, Nature Biotechnology.
[132] H. Edlund,et al. Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.
[133] James E. DiCarlo,et al. RNA-Guided Human Genome Engineering via Cas9 , 2013, Science.
[134] Jun Zhang,et al. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting , 2013, Cell Research.
[135] Y. Arai,et al. Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering , 2014, Scientific Reports.
[136] Feng Zhang,et al. CRISPR-assisted editing of bacterial genomes , 2013, Nature Biotechnology.
[137] A. Rizzino. Concise Review: The Sox2‐Oct4 Connection: Critical Players in a Much Larger Interdependent Network Integrated at Multiple Levels , 2013, Stem cells.
[138] Koji Sugiura,et al. Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease , 2013, Nucleic acids research.
[139] Dana Carroll,et al. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. , 2002, Genetics.
[140] C. Pabo,et al. DNA recognition by Cys2His2 zinc finger proteins. , 2000, Annual review of biophysics and biomolecular structure.
[141] L. Tesson,et al. Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes , 2015, PloS one.
[142] B. Hogan,et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. , 1996, Development.
[143] Yu Chen,et al. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection , 2015, Scientific Reports.
[144] Elo Leung,et al. A TALE nuclease architecture for efficient genome editing , 2011, Nature Biotechnology.
[145] Feng Zhang,et al. Genome engineering using CRISPR-Cas9 system. , 2015, Methods in molecular biology.
[146] Jin-Soo Kim,et al. Genome editing with modularly assembled zinc-finger nucleases , 2010, Nature Methods.
[147] A. Bogdanove,et al. TAL Effectors: Customizable Proteins for DNA Targeting , 2011, Science.
[148] Jian‐Kang Zhu,et al. Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System. , 2017, Molecular plant.
[149] Jiyeon Kweon,et al. TALENs and ZFNs are associated with different mutation signatures , 2013, Nature Methods.
[150] F. Guillemot,et al. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[151] Y. Kan,et al. Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac , 2014, Genome research.
[152] Dominik Niopek,et al. CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox. , 2014, Biotechnology journal.
[153] D. Ovchinnikov,et al. Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. , 2015, Stem cells and development.
[154] Karl-Ludwig Laugwitz,et al. Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Versatile Tool for Arrhythmia Research , 2013, Circulation research.
[155] M. Lieber,et al. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. , 2010, Annual review of biochemistry.
[156] Agnès E. Ricroch,et al. Next biotech plants: new traits, crops, developers and technologies for addressing global challenges , 2016, Critical reviews in biotechnology.
[157] CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success? , 2017, Stem Cell Research & Therapy.
[158] J. Vogel,et al. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III , 2011, Nature.
[159] David A. Scott,et al. In vivo genome editing using Staphylococcus aureus Cas9 , 2015, Nature.
[160] Chad A. Cowan,et al. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. , 2013, Cell stem cell.
[161] F. C. Pan,et al. Pancreas organogenesis: From bud to plexus to gland , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.
[162] Jonathan C. Cohen,et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. , 2006, The New England journal of medicine.
[163] B. Dujon,et al. Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: a new method for physical mapping of eukaryotic genomes. , 1992, Nucleic acids research.
[164] M. Chovanec,et al. DNA double-strand break repair by homologous recombination. , 2004, Mutation research.
[165] G. S. Ali,et al. Genome editing approaches: manipulating of lovastatin and taxol synthesis of filamentous fungi by CRISPR/Cas9 system , 2017, Applied Microbiology and Biotechnology.
[166] A. C. Chang,et al. Construction of biologically functional bacterial plasmids in vitro. , 1973, Proceedings of the National Academy of Sciences of the United States of America.
[167] Melissa M. Harrison,et al. A CRISPR view of development , 2014, Genes & development.
[168] Dana Carroll,et al. Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases , 2001, Molecular and Cellular Biology.
[169] O. Michielin,et al. Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. , 2003, The Journal of clinical endocrinology and metabolism.
[170] David I. Wilson,et al. Beta cell differentiation during early human pancreas development. , 2004, The Journal of endocrinology.
[171] K. C. K. Lloyd,et al. Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice , 2014, FEBS open bio.
[172] S Chandrasegaran,et al. Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. , 2000, Nucleic acids research.
[173] Kevin Kim,et al. A TALEN genome-editing system for generating human stem cell-based disease models. , 2013, Cell stem cell.
[174] J. Mozoruk,et al. Oligonucleotide‐directed mutagenesis for precision gene editing , 2015, Plant biotechnology journal.
[175] A. Das,et al. CRISPR-Cas based antiviral strategies against HIV-1. , 2017, Virus research.
[176] CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures , 2018, Scientific Reports.
[177] Emily Waltz,et al. Gene-edited CRISPR mushroom escapes US regulation , 2016, Nature.
[178] A. Marais,et al. Abstract 340: The C679X Mutation in PCSK9 is Present and Lowers Blood Cholesterol in a Southern African Population , 2006 .
[179] Jin-Soo Kim,et al. Generation of cloned adult muscular pigs with myostatin gene mutation by genetic engineering , 2017 .
[180] David Baltimore,et al. Chimeric Nucleases Stimulate Gene Targeting in Human Cells , 2003, Science.
[181] F. Zhang,et al. Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family. , 2014, Plant biotechnology journal.
[182] Philippe Horvath,et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA , 2010, Nature.
[183] Xiuping Zou,et al. Engineering canker‐resistant plants through CRISPR/Cas9‐targeted editing of the susceptibility gene CsLOB1 promoter in citrus , 2017, Plant biotechnology journal.
[184] Jere Weltner,et al. Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation , 2015, Stem cell reports.
[185] K. Musunuru. Genome editing of human pluripotent stem cells to generate human cellular disease models , 2013, Disease Models & Mechanisms.