DESIG AD EVALUATIO OF HPMC AD XATHA GUMBASED SUSTAIED RELEASE MATRIX TABLETS OF THEOPHYLLIE

Summary In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration, and improve patient compliance, by developing sustained release matrix tablets of theophylline. Hence, in the present work, an attempt has been made to develop sustained release matrix tablets using polymer such as hydroxyl propyl methyl cellulose (HPMC) and xanthan gum. The tablets were prepared by direct compression method. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using paddle method in phosphate buffer (pH 6.8) as dissolution media. Formulation F1 and F2 failed to sustain release beyond 8 hours. Among all the formulation, F3 shows 98.12% of drug release at the end of 12 hours. This finding reveals that above a particular concentration of HPMC K�100 and xanthan gum are capable of providing sustained drug release.