Gap Detection Measured With Electrically Evoked Auditory Event–Related Potentials and Speech-Perception Abilities in Children With Auditory Neuropathy Spectrum Disorder

Objectives: This study aimed (1) to investigate the feasibility of recording the electrically evoked auditory event–related potential (eERP), including the onset P1-N1-P2 complex and the electrically evoked auditory change complex (EACC) in response to temporal gaps, in children with auditory neuropathy spectrum disorder (ANSD); and (2) to evaluate the relationship between these measures and speech-perception abilities in these subjects. Design: Fifteen ANSD children who are Cochlear Nucleus device users participated in this study. For each subject, the speech-processor microphone was bypassed and the eERPs were elicited by direct stimulation of one mid-array electrode (electrode 12). The stimulus was a train of biphasic current pulses 800 msec in duration. Two basic stimulation conditions were used to elicit the eERP. In the no-gap condition, the entire pulse train was delivered uninterrupted to electrode 12, and the onset P1-N1-P2 complex was measured relative to the stimulus onset. In the gapped condition, the stimulus consisted of two pulse train bursts, each being 400 msec in duration, presented sequentially on the same electrode and separated by one of five gaps (i.e., 5, 10, 20, 50, and 100 msec). Open-set speech-perception ability of these subjects with ANSD was assessed using the phonetically balanced kindergarten (PBK) word lists presented at 60 dB SPL, using monitored live voice in a sound booth. Results: The eERPs were recorded from all subjects with ANSD who participated in this study. There were no significant differences in test–retest reliability, root mean square amplitude or P1 latency for the onset P1-N1-P2 complex between subjects with good (>70% correct on PBK words) and poorer speech-perception performance. In general, the EACC showed less mature morphological characteristics than the onset P1-N1-P2 response recorded from the same subject. There was a robust correlation between the PBK word scores and the EACC thresholds for gap detection. Subjects with poorer speech-perception performance showed larger EACC thresholds in this study. Conclusions: These results demonstrate the feasibility of recording eERPs from implanted children with ANSD, using direct electrical stimulation. Temporal-processing deficits, as demonstrated by large EACC thresholds for gap detection, might account in part for the poor speech-perception performances observed in a subgroup of implanted subjects with ANSD. This finding suggests that the EACC elicited by changes in temporal continuity (i.e., gap) holds promise as a predictor of speech-perception ability among implanted children with ANSD.

[1]  N. Kraus,et al.  Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables. , 1997, Electroencephalography and clinical neurophysiology.

[2]  K. Tremblay,et al.  Acoustic Change Complexes Recorded in Adult Cochlear Implant Listeners , 2006, Ear and hearing.

[3]  Gary Rance,et al.  Speech Perception and Cortical Event Related Potentials in Children with Auditory Neuropathy , 2002, Ear and hearing.

[4]  Carolyn J. Brown,et al.  The Electrically Evoked Auditory Change Complex: Preliminary Results from Nucleus Cochlear Implant Users , 2008, Ear and hearing.

[5]  H. Sanli,et al.  Auditory Neuropathy: An Update , 2007, Ear and hearing.

[6]  R. Shannon Temporal modulation transfer functions in patients with cochlear implants. , 1992, The Journal of the Acoustical Society of America.

[7]  M. Eckert,et al.  Human Evoked Cortical Activity to Silent Gaps in Noise: Effects of Age, Attention, and Cortical Processing Speed , 2012, Ear and hearing.

[8]  Fan-Gang Zeng,et al.  Perceptual consequences of disrupted auditory nerve activity. , 2005, Journal of neurophysiology.

[9]  Frank E Musiek,et al.  GIN (Gaps-In-Noise) performance in the pediatric population. , 2009, Journal of the American Academy of Audiology.

[10]  Chong-Sun Kim,et al.  Comparison of Cognitive Function in Deaf Children Between Before and After Cochlear Implant , 2007, Ear and hearing.

[11]  D. Langdon,et al.  The Cognition and Behaviour of Children with Cochlear Implants, Children with Hearing Aids and Their Hearing Peers: A Comparison , 2005, Audiology and Neurotology.

[12]  R. Shepherd,et al.  Maturation of the cortical auditory evoked potential in infants and young children , 2006, Hearing Research.

[13]  Christina L. Runge-Samuelson,et al.  Quantitative Analysis of Electrically Evoked Auditory Brainstem Responses in Implanted Children With Auditory Neuropathy/Dyssynchrony , 2008, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[14]  S. Petrov,et al.  Comb-filtered speech as a tool to demonstrate difficulties of speech perception and the importance of auditory training in cochlear implant users , 2011, Cochlear implants international.

[15]  Fan-Gang Zeng,et al.  N100 cortical potentials accompanying disrupted auditory nerve activity in auditory neuropathy (AN): Effects of signal intensity and continuous noise , 2009, Clinical Neurophysiology.

[16]  Y. Sininger,et al.  Cochlear implantation of auditory neuropathy. , 2000, Journal of the American Academy of Audiology.

[17]  Fan-Gang Zeng,et al.  Pathology and physiology of auditory neuropathy with a novel mutation in the MPZ gene (Tyr145->Ser). , 2003, Brain : a journal of neurology.

[18]  Carolyn J. Brown,et al.  Outcome of Cochlear Implantation in Pediatric Auditory Neuropathy , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[19]  Stéphanie Barbu,et al.  ‘Some aspects of cognitive and social development in children with cochlear implant’ , 2008, Developmental medicine and child neurology.

[20]  A. Geers,et al.  Epilogue: Major Findings, Conclusions and Implications for Deaf Education , 2003, Ear and hearing.

[21]  Fan-Gang Zeng,et al.  Auditory temporal processes in normal-hearing individuals and in patients with auditory neuropathy , 2005, Clinical Neurophysiology.

[22]  P. Abbas,et al.  The Effect of Changes in Stimulus Level on Electrically Evoked Cortical Auditory Potentials , 2009, Ear and hearing.

[23]  M. Cheatham,et al.  Consequences of neural asynchrony: A case of auditory neuropathy , 2000, Journal of the Association for Research in Otolaryngology.

[24]  B. Papsin,et al.  Characterizing responses from auditory cortex in young people with several years of cochlear implant experience , 2008, Clinical Neurophysiology.

[25]  A. Peterson,et al.  Cochlear Implants in Five Cases of Auditory Neuropathy: Postoperative Findings and Progress , 2001, The Laryngoscope.

[26]  R V Shannon,et al.  Detection of gaps in sinusoids and pulse trains by patients with cochlear implants. , 1989, The Journal of the Acoustical Society of America.

[27]  Richard A. Roberts,et al.  An adaptive clinical test of temporal resolution: Age effects , 2011, International journal of audiology.

[28]  K. Diers,et al.  Reliability of intensity dependence of auditory-evoked potentials , 2008, Clinical Neurophysiology.

[29]  R. Shannon,et al.  Absence of both auditory evoked potentials and auditory percepts dependent on timing cues. , 1991, Brain : a journal of neurology.

[30]  Gary Rance,et al.  Perceptual Characterization of Children with Auditory Neuropathy , 2004, Ear and hearing.

[31]  R. Shepherd,et al.  Clinical findings for a group of infants and young children with auditory neuropathy. , 1999, Ear and hearing.

[32]  H G Vaughan,et al.  Electrophysiological evidence of developmental changes in the duration of auditory sensory memory. , 1999, Developmental psychology.

[33]  B J Gantz,et al.  Cochlear implant use by prelingually deafened children: the influences of age at implant and length of device use. , 1997, Journal of speech, language, and hearing research : JSLHR.

[34]  M. F. Colella-Santos,et al.  Temporal Resolution: performance of school-aged children in the GIN - Gaps-in-noise test , 2010, Brazilian Journal of Otorhinolaryngology.

[35]  M. Dorman,et al.  Developmental changes in refractoriness of the cortical auditory evoked potential , 2005, Clinical Neurophysiology.

[36]  T. Carrell,et al.  Speech-evoked cortical potentials in children. , 1993, Journal of the American Academy of Audiology.

[37]  Garrett Cardon,et al.  Cortical maturation and behavioral outcomes in children with auditory neuropathy spectrum disorder , 2011, International journal of audiology.

[38]  B A Schneider,et al.  Gap detection in infants, children, and adults. , 1995, The Journal of the Acoustical Society of America.

[39]  F. Zeng,et al.  Perspectives on Auditory Neuropathy: Disorders of Inner Hair Cell, Auditory Nerve, and Their Synapse , 2008 .

[40]  K. Tremblay,et al.  Speech Evoked Potentials: From the Laboratory to the Clinic , 2008, Ear and hearing.

[41]  Arthur Boothroyd,et al.  Stimulus Presentation Strategies for Eliciting the Acoustic Change Complex: Increasing Efficiency , 2010, Ear and hearing.

[42]  Lei Gao,et al.  Auditory neuropathy. , 2015, Handbook of clinical neurology.

[43]  C. Berlin,et al.  Does Type I afferent neuron dysfunction reveal itself through lack of efferent suppression? , 1993, Hearing Research.

[44]  Y Sininger,et al.  Temporal and speech processing de ® cits in auditory neuropathy , 1999 .

[45]  C. Zdanski,et al.  Cochlear Implantation in Children with Auditory Neuropathy Spectrum Disorder , 2010, Ear and hearing.

[46]  Y. Sininger,et al.  Electrical Stimulation of the Auditory Nerve via Cochlear Implants in Patients with Auditory Neuropathy , 2002, The Annals of otology, rhinology & laryngology. Supplement.

[47]  D. Pisoni,et al.  New directions for assessing speech perception in persons with sensory aids. , 1995, The Annals of otology, rhinology & laryngology. Supplement.

[48]  V. Narne,et al.  Behavioral and Brain Functions , 2007 .

[49]  R. Miyamoto,et al.  Effects of Age at Implantation in Young Children , 2002, The Annals of otology, rhinology & laryngology. Supplement.

[50]  D. Choo,et al.  Pediatric Cochlear Implantation in Auditory Neuropathy , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[51]  F. Zeng,et al.  Auditory cortical N100 in pre- and post-synaptic auditory neuropathy to frequency or intensity changes of continuous tones , 2011, Clinical Neurophysiology.

[52]  G. Rance Auditory Neuropathy/Dys-synchrony and Its Perceptual Consequences , 2005, Trends in amplification.

[53]  Joanna Walton,et al.  Predicting Cochlear Implant Outcomes in Children With Auditory Neuropathy , 2008, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[54]  J. Eggermont,et al.  Maturation of human central auditory system activity: evidence from multi-channel evoked potentials , 2000, Clinical Neurophysiology.

[55]  D. Kurtzberg,et al.  Spatiotemporal maturation of the central and lateral N1 components to tones. , 2001, Brain research. Developmental brain research.

[56]  J. Eggermont,et al.  Maturation of Human Cortical Auditory Function: Differences Between Normal‐Hearing Children and Children with Cochlear Implants , 1996, Ear and hearing.

[57]  J. Singleton,et al.  Developmental social cognitive neuroscience: insights from deafness. , 2009, Child development.

[58]  R. Patuzzi,et al.  Frequency-Specific Electrocochleography Indicates that Presynaptic and Postsynaptic Mechanisms of Auditory Neuropathy Exist , 2008, Ear and hearing.