E2A-HLF usurps control of evolutionarily conserved survival pathways

[1]  C. Chu,et al.  Identification of the E2A Gene Products as Regulatory Targets of the G1 Cyclin-dependent Kinases* , 2001, The Journal of Biological Chemistry.

[2]  S. Korsmeyer,et al.  The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. , 2000, Molecular cell.

[3]  Y. Ip,et al.  Snail/slug family of repressors: slowly going into the fast lane of development and cancer. , 2000, Gene.

[4]  D. LeBrun,et al.  Role for Homodimerization in Growth Deregulation by E2a Fusion Proteins , 2000, Molecular and Cellular Biology.

[5]  Y. Ip,et al.  Human Slug Is a Repressor That Localizes to Sites of Active Transcription , 2000, Molecular and Cellular Biology.

[6]  S. Yamaguchi,et al.  Role of DBP in the Circadian Oscillatory Mechanism , 2000, Molecular and Cellular Biology.

[7]  P. D. de Jong,et al.  The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  A. G. Herreros,et al.  The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells , 2000, Nature Cell Biology.

[9]  Francisco Portillo,et al.  The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression , 2000, Nature Cell Biology.

[10]  Michael W Young,et al.  Cycling vrille Expression Is Required for a Functional Drosophila Clock , 1999, Cell.

[11]  C. Murre,et al.  Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47 , 1999, The Journal of experimental medicine.

[12]  Xiao-Hong Sun,et al.  Massive Apoptosis of Thymocytes in T-Cell-Deficient Id1 Transgenic Mice , 1999, Molecular and Cellular Biology.

[13]  C. Murre,et al.  E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination , 1999, The EMBO journal.

[14]  A. Look,et al.  SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. , 1999, Molecular cell.

[15]  H. Horvitz,et al.  The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. , 1999, Molecular cell.

[16]  Kevin S. Smith,et al.  Disrupted Differentiation and Oncogenic Transformation of Lymphoid Progenitors in E2A-HLFTransgenic Mice , 1999, Molecular and Cellular Biology.

[17]  A. Look,et al.  Two Distinct Interleukin-3-Mediated Signal Pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, Regulate the Survival of Murine Pro-B Lymphocytes , 1999, Molecular and Cellular Biology.

[18]  C. Caslini,et al.  Identification of a novel molecular partner of the E2A gene in childhood leukemia , 1999, Leukemia.

[19]  A. Look,et al.  Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice , 1999, Brain Research.

[20]  C. Murre,et al.  Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  G. Nolan,et al.  Growth Inhibition and Apoptosis Due to Restoration of E2A Activity in T Cell Acute Lymphoblastic Leukemia Cells , 1999, The Journal of experimental medicine.

[22]  D. Lillicrap,et al.  Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes. , 1999, DNA and cell biology.

[23]  Thorsten Schmidt,et al.  Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis , 1998, Oncogene.

[24]  M. Takeichi,et al.  Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. , 1998, Developmental biology.

[25]  A. Look,et al.  The AD1 and AD2 Transactivation Domains of E2A Are Essential for the Antiapoptotic Activity of the Chimeric Oncoprotein E2A-HLF , 1998, Molecular and Cellular Biology.

[26]  H. Horvitz,et al.  Genetics of programmed cell death in C. elegans: past, present and future. , 1998, Trends in genetics : TIG.

[27]  L. Mcgavran,et al.  Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations , 1998, Leukemia.

[28]  J. Sundberg,et al.  The Slug gene is not essential for mesoderm or neural crest development in mice. , 1998, Developmental biology.

[29]  J D Norton,et al.  Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation , 1997, Molecular and cellular biology.

[30]  R. Benezra,et al.  High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice , 1997, Molecular and cellular biology.

[31]  S. Antonarakis,et al.  Peutz-Jeghers syndrome: confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4. , 1997, American journal of human genetics.

[32]  Ueli Schibler,et al.  The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior , 1997, The EMBO journal.

[33]  A T Look,et al.  Oncogenic transcription factors in the human acute leukemias. , 1997, Science.

[34]  S. T. Park,et al.  Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins , 1997, Molecular and cellular biology.

[35]  D. Louis,et al.  Molecular Genetic Evidence for Subtypes of Oligoastrocytomas , 1997, Journal of neuropathology and experimental neurology.

[36]  D. Pinkel,et al.  E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas , 1997, Molecular and cellular biology.

[37]  K. Ault,et al.  Loss of heterozygosity in human ovarian cancer on chromosome 19q. , 1997, Gynecologic oncology.

[38]  J L Cleveland,et al.  Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Look,et al.  Cell transformation mediated by homodimeric E2A-HLF transcription factors , 1997, Molecular and cellular biology.

[40]  G. Peters,et al.  Cdk2‐dependent phosphorylation of Id2 modulates activity of E2A‐related transcription factors , 1997, The EMBO journal.

[41]  C. Gilks,et al.  The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[42]  A. Look,et al.  Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor , 1996, Nature.

[43]  H. Horvitz,et al.  Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2 , 1996, Nature.

[44]  D. D. Duncan,et al.  Asymmetric redundancy in CD4 silencer function. , 1996, Immunity.

[45]  S. Hunger,et al.  Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. , 1996, Blood.

[46]  G. Wanner,et al.  The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue‐specific expression, but have different target promoter preferences. , 1996, The EMBO journal.

[47]  Wei Zhang,et al.  Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter , 1995, Molecular and cellular biology.

[48]  F. Fleury-Olela,et al.  The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. , 1995, The EMBO journal.

[49]  T. Kadesch,et al.  B-cell-specific DNA binding by an E47 homodimer , 1995, Molecular and cellular biology.

[50]  T. Inaba,et al.  E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF , 1995, Molecular and cellular biology.

[51]  Xiao-Hong Sun.  Constitutive expression of the Id1 gene impairs mouse B cell development , 1994, Cell.

[52]  H. Weintraub,et al.  The helix-loop-helix gene E2A is required for B cell formation , 1994, Cell.

[53]  D. LeBrun,et al.  Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable , 1994, Molecular and cellular biology.

[54]  M. Cleary,et al.  DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF , 1994, Molecular and cellular biology.

[55]  R. Pepperkok,et al.  Regulation of G1 progression by E2A and Id helix‐loop‐helix proteins. , 1994, The EMBO journal.

[56]  R. Pepperkok,et al.  Id proteins control growth induction in mammalian cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Ian G. Cowell,et al.  Transcriptional repression by the human bZIP factor E4BP4: definition of a minimal repression domain , 1994, Nucleic Acids Res..

[58]  David P. LeBrun,et al.  Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice , 1993, Cell.

[59]  D. Littman,et al.  A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines , 1993, Molecular and cellular biology.

[60]  C. Murre,et al.  Localization of E2A mRNA expression in developing and adult rat tissues. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[61]  C. Murre,et al.  E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins , 1993, Molecular and cellular biology.

[62]  C. Gilks,et al.  Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein , 1993, Molecular and cellular biology.

[63]  S. Gandevia.  MUSCLE FATIGUE: Does the diaphragm fatigue during parturition? , 1993 .

[64]  T. Lion,et al.  Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia. , 1992, Blood.

[65]  M. Cleary,et al.  Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. , 1992, Genes & development.

[66]  S. Raimondi,et al.  Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. , 1992, Science.

[67]  H. Hurst,et al.  Transcriptional repression by a novel member of the bZIP family of transcription factors , 1992, Molecular and cellular biology.

[68]  D. Lavery,et al.  The role of the transcriptional activator protein DBP in circadian liver gene expression , 1992, Journal of Cell Science.

[69]  L. Swanson,et al.  TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. , 1991, Genes & development.

[70]  D. Baltimore,et al.  B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits , 1991, Molecular and cellular biology.

[71]  D. Baltimore,et al.  An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers , 1991, Cell.

[72]  C. Nelson,et al.  Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins , 1990, Molecular and cellular biology.

[73]  R. Pepperkok,et al.  Cell proliferation inhibited by MyoD1 independently of myogenic differentiation , 1990, Nature.

[74]  U. Schibler,et al.  DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally , 1990, Cell.

[75]  David Baltimore,et al.  A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all , 1990, Cell.

[76]  Michael L. Cleary,et al.  Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor , 1990, Cell.

[77]  T. Kadesch,et al.  Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. , 1990, Nucleic acids research.

[78]  T. Kadesch,et al.  Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. , 1990, Science.

[79]  Y. Jan,et al.  Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence , 1989, Cell.

[80]  David Baltimore,et al.  A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins , 1989, Cell.

[81]  A. Look.  E2A-HLF chimeric transcription factors in pro-B cell acute lymphoblastic leukemia. , 1997, Current topics in microbiology and immunology.

[82]  George Ellis,et al.  CHAPTER 6 – Introduction to Filters , 1991 .

[83]  J. L. Boulay,et al.  The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers , 1987, Nature.