The cardiovascular risk profile of middle‐aged women with polycystic ovary syndrome

Contradictory results have been reported regarding the association between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD). We assessed the cardiometabolic phenotype and prevalence of CVD in middle‐aged women with PCOS, compared with age‐matched controls from the general population, and estimated 10‐year CVD risk and cardiovascular health score.

[1]  O. Franco,et al.  High Androgens in Postmenopausal Women and the Risk for Atherosclerosis and Cardiovascular Disease: The Rotterdam Study , 2018, The Journal of clinical endocrinology and metabolism.

[2]  D. Glintborg,et al.  Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome , 2018, Cardiovascular Diabetology.

[3]  M. Mansournia,et al.  Prediction of age at menopause in women with polycystic ovary syndrome , 2018, Climacteric : the journal of the International Menopause Society.

[4]  O. Franco,et al.  The Rotterdam Study: 2018 update on objectives, design and main results , 2017, European Journal of Epidemiology.

[5]  D. Glintborg,et al.  Development and Risk Factors of Type 2 Diabetes in a Nationwide Population of Women With Polycystic Ovary Syndrome , 2017, The Journal of clinical endocrinology and metabolism.

[6]  B. Fauser,et al.  Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life? , 2017, Climacteric : the journal of the International Menopause Society.

[7]  M. Järvelin,et al.  Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus-a prospective population-based cohort study. , 2017, Human reproduction.

[8]  A. Ruokonen,et al.  Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life. , 2017, Fertility and sterility.

[9]  E. Diamanti-Kandarakis,et al.  Is cardiovascular risk in women with PCOS a real risk? Current insights. , 2017, Minerva endocrinologica.

[10]  E. Karabulut,et al.  The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. , 2016, Human reproduction.

[11]  A. Uitterlinden,et al.  Menopause: Genome stability as new paradigm. , 2016, Maturitas.

[12]  S. Reis,et al.  Cardiovascular Disease and 10-Year Mortality in Postmenopausal Women with Clinical Features of Polycystic Ovary Syndrome. , 2016, Journal of women's health.

[13]  O. Franco,et al.  Cardiovascular Risk in Women With Premature Ovarian Insufficiency Compared to Premenopausal Women at Middle Age. , 2016, The Journal of clinical endocrinology and metabolism.

[14]  Bjarni V. Halldórsson,et al.  Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome , 2015, Nature Communications.

[15]  Shinn-Zong Lin,et al.  Coronary artery disease risk in young women with polycystic ovary syndrome , 2015, Oncotarget.

[16]  R. Calderon-Margalit,et al.  Prospective Association of Polycystic Ovary Syndrome With Coronary Artery Calcification and Carotid-Intima-Media Thickness: The Coronary Artery Risk Development in Young Adults Women’s Study , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[17]  M. Eijkemans,et al.  Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? , 2014, Fertility and sterility.

[18]  O. Lao,et al.  The impact of self-reported ethnicity versus genetic ancestry on phenotypic characteristics of polycystic ovary syndrome (PCOS). , 2014, The Journal of clinical endocrinology and metabolism.

[19]  Stéphane Laurent,et al.  Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors. , 2013, European heart journal.

[20]  J. Qiao,et al.  Ethnic differences in the phenotypic expression of polycystic ovary syndrome , 2013, Steroids.

[21]  P. Alagona,et al.  The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. , 2012, Journal of the American College of Cardiology.

[22]  Mark D. Huffman,et al.  Cardiovascular Health Behavior and Health Factor Changes (1988–2008) and Projections to 2020: Results From the National Health and Nutrition Examination Surveys , 2012, Circulation.

[23]  Angela M. Malek,et al.  Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis. , 2012, Human reproduction update.

[24]  M. Brännström,et al.  Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study. , 2011, The Journal of clinical endocrinology and metabolism.

[25]  G. Braunstein,et al.  The relationship of menopausal status and rapid menopausal transition with carotid intima-media thickness progression in women: a report from the Los Angeles Atherosclerosis Study. , 2010, The Journal of clinical endocrinology and metabolism.

[26]  M. Solaymani-Dodaran,et al.  Is polycystic ovary syndrome an exception for reproductive aging? , 2010, Human reproduction.

[27]  D. Mozaffarian,et al.  Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association's Strategic Impact Goal Through 2020 and Beyond , 2010, Circulation.

[28]  Zoe Ann Brown,et al.  The phenotype of polycystic ovary syndrome ameliorates with aging. , 2009, Fertility and sterility.

[29]  M. Pencina,et al.  General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study , 2008, Circulation.

[30]  R. Steegers-Theunissen,et al.  A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study. , 2008, The Journal of clinical endocrinology and metabolism.

[31]  Matthias W. Lorenz,et al.  Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis , 2007, Circulation.

[32]  A. Khatibi,et al.  Could androgens protect middle-aged women from cardiovascular events? A population-based study of Swedish women: The Women's Health in the Lund Area (WHILA) Study , 2007, Climacteric : the journal of the International Menopause Society.

[33]  H. Teede,et al.  Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease. , 2005, The Journal of clinical endocrinology and metabolism.

[34]  L. Kuller,et al.  Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[35]  Arno W. Hoes,et al.  Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. , 1997, Circulation.

[36]  S. Johansson,et al.  Polycystic ovary syndrome and risk for myocardial infarction: Evaluated from a risk factor model based on a prospective population study of women , 1992, Acta obstetricia et gynecologica Scandinavica.

[37]  G. Watts,et al.  Carotid artery plaques and intima medial thickness in familial hypercholesteraemic patients on long-term statin therapy: A case control study. , 2017, Atherosclerosis.

[38]  Enrico Carmina,et al.  Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. , 2012, Fertility and sterility.

[39]  Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. , 2004, Fertility and sterility.

[40]  B. Fauser,et al.  Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). , 2004, Human reproduction.

[41]  Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. , 2002, Circulation.