Simultaneous multiagent hyperpolarized 13C perfusion imaging

To demonstrate simultaneous hyperpolarization and imaging of three 13C‐labeled perfusion MRI contrast agents with dissimilar molecular structures ([13C]urea, [13C]hydroxymethyl cyclopropane, and [13C]t‐butanol) and correspondingly variable chemical shifts and physiological characteristics, and to exploit their varying diffusibility for simultaneous measurement of vascular permeability and perfusion in initial preclinical studies.

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