Surfactant-controlled morphology and magnetic property of manganese ferrite nanocrystal contrast agent

MnFe2O4 nanocrystals (NCs) coated with three different surfactants (oleic acid, oleylamine or 1,2-hexadecanediol) and their mixtures, with sizes in range 6–12 nm, were synthesized by high-temperature decomposition of organometallic precursors. The effects of morphology and surface chemistry of MnFe2O4 NCs on the magnetic properties were systematically investigated by comparing their saturation magnetization values and their capability to improve the negative contrast for magnetic resonance imaging (MRI) after converting the hydrophobic NCs to hydrophilic ones by a ligand exchange protocol. An important finding is that the magnetization values and proton relaxivity rates of MnFe2O4 NCs are strongly dependent on the size and surface state of the particles that covalently bonded with different hydrophobic ligands before ligand exchange. In particular, monodisperse cubic MnFe2O4 NCs could be obtained when oleylamine and 1,2-hexadecanediol were used as mixed stabilizers, and showed excellent morphology and magnetic properties. Furthermore, the low cytotoxicity and good cell uptake MR imaging of the dopamine capped MnFe2O4 NCs make them promising candidates for use as bio-imaging probes.

[1]  Zhichuan J. Xu,et al.  Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles , 2010, Advanced materials.

[2]  Xiaoxia Du,et al.  Silica‐Coated Manganese Oxide Nanoparticles as a Platform for Targeted Magnetic Resonance and Fluorescence Imaging of Cancer Cells , 2010 .

[3]  M. Farle,et al.  Magnetic Hardness of Fe 60 Pt 40 Nanoparticles Controlled by Surface Chemistry , 2010 .

[4]  Angelique Louie,et al.  Multimodality imaging probes: design and challenges. , 2010, Chemical reviews.

[5]  Xiaoxia Du,et al.  Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. , 2010, Biomaterials.

[6]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[7]  Jinwoo Cheon,et al.  Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology , 2009 .

[8]  Fuyou Li,et al.  Hydrothermal synthesis of hexagonal lanthanide-doped LaF3 nanoplates with bright upconversion luminescence , 2008, Nanotechnology.

[9]  S. Nie,et al.  Reexamining the Effects of Particle Size and Surface Chemistry on the Magnetic Properties of Iron Oxide Nanocrystals: New Insights into Spin Disorder and Proton Relaxivity , 2008 .

[10]  J. Cheon,et al.  Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. , 2008, Accounts of chemical research.

[11]  J. Marco,et al.  Effect of Nature and Particle Size on Properties of Uniform Magnetite and Maghemite Nanoparticles , 2007 .

[12]  Yong Ding,et al.  Tuning the Thermal Stability of Molecular Precursors for the Nonhydrolytic Synthesis of Magnetic MnFe2O4 Spinel Nanocrystals , 2007 .

[13]  Oliver T. Bruns,et al.  Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. , 2007, Nano letters.

[14]  Taeghwan Hyeon,et al.  Synthesis of monodisperse spherical nanocrystals. , 2007, Angewandte Chemie.

[15]  M. Kovalenko,et al.  Fatty acid salts as stabilizers in size- and shape-controlled nanocrystal synthesis: the case of inverse spinel iron oxide. , 2007, Journal of the American Chemical Society.

[16]  Zhichuan J. Xu,et al.  Linking Hydrophilic Macromolecules to Monodisperse Magnetite (Fe(3)O(4)) Nanoparticles via Trichloro-s-triazine. , 2006, Chemistry of materials : a publication of the American Chemical Society.

[17]  C. Serna,et al.  Surfactant effects in magnetite nanoparticles of controlled size , 2006, cond-mat/0609384.

[18]  Jin-Sil Choi,et al.  Shape control of semiconductor and metal oxide nanocrystals through nonhydrolytic colloidal routes. , 2006, Angewandte Chemie.

[19]  C. Serna,et al.  Structural and magnetic properties of uniform magnetite nanoparticles prepared by high temperature decomposition of organic precursors , 2006 .

[20]  Jinwoo Cheon,et al.  Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. , 2005, Journal of the American Chemical Society.

[21]  Taeghwan Hyeon,et al.  Ultra-large-scale syntheses of monodisperse nanocrystals , 2004, Nature materials.

[22]  Shan X. Wang,et al.  Shape-controlled synthesis and shape-induced texture of MnFe2O4 nanoparticles. , 2004, Journal of the American Chemical Society.

[23]  Bing Xu,et al.  Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. , 2004, Journal of the American Chemical Society.

[24]  Hao Zeng,et al.  Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. , 2004, Journal of the American Chemical Society.

[25]  Berkowitz,et al.  Surface Spin Disorder in NiFe2O4 Nanoparticles. , 1996, Physical review letters.

[26]  Jinwoo Cheon,et al.  Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging , 2007, Nature Medicine.

[27]  P. Guardiaa,et al.  Surfactant effects in magnetite nanoparticles of controlled size , 2007 .

[28]  Hao Zeng,et al.  Monodisperse MFe 2 O 4 ( M ) Fe , Co , Mn ) Nanoparticles , 2022 .