The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis

[1]  Xiang-Dong Fu,et al.  LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs , 2022, Science.

[2]  P. Gos,et al.  The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition. , 2022, Molecular cell.

[3]  S. Keeney,et al.  YTHDC2 control of gametogenesis requires helicase activity but not m6A binding , 2022, Genes & development.

[4]  P. Jordan,et al.  Overlapping roles for PLK1 and aurora A during meiotic centrosome biogenesis in mouse spermatocytes , 2021, EMBO reports.

[5]  S. Keeney,et al.  YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis , 2021, bioRxiv.

[6]  M. Malumbres,et al.  PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis , 2021, EMBO reports.

[7]  Cuiping Yang,et al.  The role of m6A modification in the biological functions and diseases , 2021, Signal Transduction and Targeted Therapy.

[8]  Gene W. Yeo,et al.  Context-dependent functional compensation between Ythdf m6A reader proteins , 2020, Genes & development.

[9]  Yong Xu,et al.  Common genetic variants in PRRC2A are associated with both neuromyelitis optica spectrum disorder and multiple sclerosis in Han Chinese population , 2020, Journal of Neurology.

[10]  X. Zhuang,et al.  m6A-binding YTHDF proteins promote stress granule formation , 2020, Nature Chemical Biology.

[11]  Yi Zheng,et al.  YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway , 2020, Cell Death & Disease.

[12]  Stuart A. Wilson,et al.  The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus , 2019, eLife.

[13]  Anthony O. Olarerin-George,et al.  m6A enhances the phase separation potential of mRNA , 2019, Nature.

[14]  Chuan He,et al.  Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. , 2019, Molecular cell.

[15]  Alireza Hadj Khodabakhshi,et al.  Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.

[16]  Yi Zheng,et al.  FTO Knockout Causes Chromosome Instability and G2/M Arrest in Mouse GC-1 Cells , 2019, Front. Genet..

[17]  Yousheng Shu,et al.  A novel m6A reader Prrc2a controls oligodendroglial specification and myelination , 2018, Cell Research.

[18]  K. Niakan,et al.  SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice , 2018, Developmental cell.

[19]  Hongjun Song,et al.  Fragile X mental retardation protein modulates the stability of its m6A‐marked messenger RNA targets , 2018, Human molecular genetics.

[20]  Michael J. Sweredoski,et al.  FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells. , 2018, Cell reports.

[21]  Z. Ignatova,et al.  Dynamic m6A methylation facilitates mRNA triaging to stress granules , 2018, Life Science Alliance.

[22]  B. Gregory,et al.  Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development , 2018, PLoS genetics.

[23]  D. Wolgemuth,et al.  BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis , 2018, PLoS genetics.

[24]  N. Kotaja,et al.  Germ granule-mediated RNA regulation in male germ cells. , 2018, Reproduction.

[25]  Anne-Claude Gingras,et al.  High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. , 2018, Molecular cell.

[26]  Stefan Hüttelmaier,et al.  Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation , 2018, Nature Cell Biology.

[27]  Nam-Hyung Kim,et al.  Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  A. Marston,et al.  Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis , 2017, Front. Cell Dev. Biol..

[29]  Ravi Sachidanandam,et al.  Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline. , 2017, Molecular cell.

[30]  Xuerui Yang,et al.  Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis , 2017, Cell Research.

[31]  Howard Y. Chang,et al.  The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline , 2017, eLife.

[32]  Chuan He,et al.  Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis , 2017, Cell Research.

[33]  Xiu-Jie Wang,et al.  Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation , 2017, Cell Research.

[34]  Christopher E Mason,et al.  ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 , 2017, bioRxiv.

[35]  J. Baur,et al.  Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  D. Page,et al.  Meioc maintains an extended meiotic prophase I in mice , 2017, PLoS genetics.

[37]  Nian Liu,et al.  N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein , 2017, Nucleic acids research.

[38]  H. Maiato,et al.  Mechanisms of Chromosome Congression during Mitosis , 2017, Biology.

[39]  Yun-Gui Yang,et al.  Cytoplasmic m6A reader YTHDF3 promotes mRNA translation , 2017, Cell Research.

[40]  Chuan He,et al.  YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA , 2017, Cell Research.

[41]  Ok Hyun Park,et al.  Identification and molecular characterization of cellular factors required for glucocorticoid receptor-mediated mRNA decay , 2016, Genes & development.

[42]  R. Parker,et al.  Principles and Properties of Stress Granules. , 2016, Trends in cell biology.

[43]  Sabine Petry.  Mechanisms of Mitotic Spindle Assembly. , 2016, Annual review of biochemistry.

[44]  R. Jessberger,et al.  Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay , 2016, PLoS genetics.

[45]  Xuerui Yang,et al.  Genome-wide assessment of differential translations with ribosome profiling data , 2016, Nature Communications.

[46]  Samir Adhikari,et al.  Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. , 2016, Molecular cell.

[47]  James M. A. Turner.  Meiotic Silencing in Mammals. , 2015, Annual review of genetics.

[48]  Olivier Elemento,et al.  5′ UTR m6A Promotes Cap-Independent Translation , 2015, Cell.

[49]  Saeed Tavazoie,et al.  HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events , 2015, Cell.

[50]  Chuan He,et al.  N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency , 2015, Cell.

[51]  Hongbing Shen,et al.  Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. , 2015, American journal of human genetics.

[52]  Chuan He,et al.  N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions , 2015, Nature.

[53]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[54]  J. Walter,et al.  The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. , 2014, Molecular cell.

[55]  V. Gaysinskaya,et al.  Optimized flow cytometry isolation of murine spermatocytes , 2014, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[56]  J. Toppari,et al.  An atlas of chromatoid body components , 2014, RNA.

[57]  L. O’Donnell.  Mechanisms of spermiogenesis and spermiation and how they are disturbed , 2014, Spermatogenesis.

[58]  Miao Yu,et al.  A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation , 2013, Nature chemical biology.

[59]  Zhike Lu,et al.  m6A-dependent regulation of messenger RNA stability , 2013, Nature.

[60]  Wei Shi,et al.  featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..

[61]  F. Baudat,et al.  Meiotic recombination in mammals: localization and regulation , 2013, Nature Reviews Genetics.

[62]  A. Bradley,et al.  ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing , 2013, Genes & development.

[63]  T. Mikkelsen,et al.  Cellular source and mechanisms of high transcriptome complexity in the mammalian testis. , 2013, Cell reports.

[64]  Arne Klungland,et al.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. , 2013, Molecular cell.

[65]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[66]  J. Wang,et al.  Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population. , 2012, Genetics and molecular research : GMR.

[67]  Yong Zhang,et al.  Identifying ChIP-seq enrichment using MACS , 2012, Nature Protocols.

[68]  Kunbin Qu,et al.  Selective Depletion of rRNA Enables Whole Transcriptome Profiling of Archival Fixed Tissue , 2012, PloS one.

[69]  Anna M. McGeachy,et al.  The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments , 2012, Nature Protocols.

[70]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[71]  O. Elemento,et al.  Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons , 2012, Cell.

[72]  M. Kupiec,et al.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq , 2012, Nature.

[73]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[74]  Chengqi Yi,et al.  N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO , 2011, Nature chemical biology.

[75]  N. Kotaja,et al.  Chromatoid body and small RNAs in male germ cells. , 2011, Reproduction.

[76]  Marcel Martin.  Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[77]  A. Nussenzweig,et al.  MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. , 2011, Genes & development.

[78]  K. Luby-Phelps,et al.  WNK1 is required for mitosis and abscission , 2011, Proceedings of the National Academy of Sciences.

[79]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[80]  M. Mitchell,et al.  Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility , 2010, Current Biology.

[81]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[82]  M. Handel,et al.  Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes , 2010, Development.

[83]  John C. Schimenti,et al.  Genetics of mammalian meiosis: regulation, dynamics and impact on fertility , 2010, Nature Reviews Genetics.

[84]  Aaron R. Quinlan,et al.  Bioinformatics Applications Note Genome Analysis Bedtools: a Flexible Suite of Utilities for Comparing Genomic Features , 2022 .

[85]  T. Baba,et al.  Characterization of Two Cytoplasmic Poly(A)-Binding Proteins, PABPC1 and PABPC2, in Mouse Spermatogenic Cells1 , 2009, Biology of reproduction.

[86]  Ellen Kampman,et al.  Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity , 2009, Nature Genetics.

[87]  R. Schultz,et al.  CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation. , 2008, Developmental biology.

[88]  J. Caldwell,et al.  Human Cep192 Is Required for Mitotic Centrosome and Spindle Assembly , 2007, Current Biology.

[89]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[90]  K. Jones,et al.  Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization. , 2004, Molecular human reproduction.

[91]  Y. Zhu,et al.  HLA class III region and susceptibility to rheumatoid arthritis. , 2000, Clinical and experimental rheumatology.

[92]  N. Nakamura,et al.  Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus , 1999, Human Genetics.

[93]  F. Rottman,et al.  Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. , 1994, The Journal of biological chemistry.