Detection of microbleeds in post‐mortem brains of patients with frontotemporal lobar degeneration: a 7.0‐Tesla magnetic resonance imaging study with neuropathological correlates

Microbleeds (MBs) are frequently detected in brains of patients with Alzheimer dementia and rare in those with frontotemporal lobar degeneration (FTLD). This study investigates for the first time the topographic distribution of MBs on a T2*‐weighted gradient‐echo 7.0‐T magnetic resonance imaging (MRI) in post‐mortem FTLD brains.

[1]  D. Leys,et al.  Cerebrovascular Lesions in Patients with Frontotemporal Lobar Degeneration: A Neuropathological Study , 2012, Neurodegenerative Diseases.

[2]  Nick C. Fox,et al.  Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration , 2011, Brain : a journal of neurology.

[3]  S. Cappa,et al.  White matter damage in frontotemporal lobar degeneration spectrum , 2011, Alzheimer's & Dementia.

[4]  Guy B. Williams,et al.  Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. , 2011, Brain : a journal of neurology.

[5]  M Filippi,et al.  Whole brain structural changes predict the mild cognitive impairment to Alzheimer's disease conversion: Evidence from the Alzheimer's Disease Neuroimaging Initiative , 2011, Alzheimer's & Dementia.

[6]  D. Leys,et al.  The impact of cerebral amyloid angiopathy on the occurrence of cerebrovascular lesions in demented patients with Alzheimer features: a neuropathological study , 2011, European journal of neurology.

[7]  D. Leys,et al.  Comparison of 7.0-T T2*-Magnetic Resonance Imaging of Cerebral Bleeds in Post-Mortem Brain Sections of Alzheimer Patients with Their Neuropathological Correlates , 2011, Cerebrovascular Diseases.

[8]  J. Wardlaw,et al.  Post-Mortem MR Brain Imaging Comparison with Macro- and Histopathology: Useful, Important and Underused , 2011, Cerebrovascular Diseases.

[9]  D. Leys,et al.  Prevalence of small cerebral bleeds in patients with a neurodegenerative dementia: A neuropathological study , 2011, Journal of the Neurological Sciences.

[10]  D. Neary,et al.  Pathological correlates of frontotemporal lobar degeneration in the elderly , 2011, Acta Neuropathologica.

[11]  P. Scheltens,et al.  Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old , 2010, Neurology.

[12]  Peter Seres,et al.  Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study , 2010, NeuroImage.

[13]  M. Nishizawa,et al.  [A case of amyotrophic lateral sclerosis/frontotemporal lobar degeneration with apraxia of eyelid opening]. , 2010, Rinsho shinkeigaku = Clinical neurology.

[14]  C R Jack,et al.  Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia , 2010, Neurology.

[15]  F. Pasquier,et al.  Prediction of pathology in primary progressive language and speech disorders , 2010, Neurology.

[16]  M. Targosz-Gajniak,et al.  Cerebral white matter lesions in patients with dementia – from MCI to severe Alzheimer's disease , 2009, Journal of the Neurological Sciences.

[17]  H. Engler,et al.  Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation , 2009, Alzheimer disease and associated disorders.

[18]  Steven Warach,et al.  Cerebral Microbleeds : A Field Guide to their Detection and Interpretation , 2012 .

[19]  Frederik Barkhof,et al.  MRI Biomarkers of Vascular Damage and Atrophy Predicting Mortality in a Memory Clinic Population , 2009, Stroke.

[20]  W. Kamphorst,et al.  Distinct genetic forms of frontotemporal dementia , 2008, Neurology.

[21]  J. Wardlaw,et al.  Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. , 2007, Brain : a journal of neurology.

[22]  J. Schneider,et al.  Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration , 2007, Acta Neuropathologica.

[23]  J. Jeret.  Prevalence and severity of microbleeds in a memory clinic setting , 2007, Neurology.

[24]  Julie S. Snowden,et al.  Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype , 2006, Acta Neuropathologica.

[25]  D. Werring,et al.  Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. , 2004, Brain : a journal of neurology.

[26]  F. Pasquier,et al.  Natural History of Frontotemporal Dementia: Comparison with Alzheimer’s Disease , 2004, Dementia and Geriatric Cognitive Disorders.

[27]  P. Santens,et al.  Cobalt-55 positron emission tomography in vascular dementia: significance of white matter changes , 2001, Journal of the Neurological Sciences.

[28]  Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[29]  D. Decoo,et al.  Cerebral blood-flow and oxygen-metabolism in leukoaraiosis: a positron emission tomography study , 1991 .

[30]  S. Atlas,et al.  Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T. Comparison with spin-echo imaging and clinical applications. , 1988, Radiology.

[31]  J. Dereuck.  The cortico-subcortical arterial angio-architecture in the human brain. , 1972 .

[32]  J. De Reuck.  The cortico-subcortical arterial angio-architecture in the human brain. , 1972, Acta Neurologica Belgica.