The evolution of colorectal carcinoma.

Pathologists and radiologists have much in common over the whole range of hospital practice but, in particular, we share a deep interest in the morphological aspects of oncolog). In this lecture I shall be describing the histopathology of the polyp-cancer or adenoma-carcinoma sequence in the large bowel which is now widely accepted as the morphological basis for the evolution of colorectal cancer. This concept has profound importance for research into those genetic and environmental factors believed to be important in the causation of cancer of the large bowel (Morson et al., 1983). It influences the surgical treatment of patients, but here I will be concentrating on the morphological sequence of events, the time it takes for these to evolve and the clinical application of these studies.

[1]  G. Ekelund,et al.  Histopathological analysis of benign polyps in patients with carcinoma of the colon and rectum , 1974, Gut.

[2]  Lester J. Blatt,et al.  Polyps of the colon and rectum , 1961 .

[3]  B C Morson,et al.  Factors influencing the prognosis of early cancer of the rectum. , 1966, Proceedings of the Royal Society of Medicine.

[4]  J. Welch,et al.  Villous adenomas of the colorectum. , 1976, American journal of surgery.

[5]  T. Oohara,et al.  Studies on the difference of background mucosa among single advanced carcinoma and benign diseases of the large intestine, and familial polyposis coli , 1980, Cancer.

[6]  H. Enterline,et al.  Malignant potential of adenomas of colon and rectum. , 1962, JAMA.

[7]  E. C. Hammond,et al.  Adenomatous lesions of the large bowel: An autopsy survey , 1979, Cancer.

[8]  H. Stalsberg,et al.  Polyps of the large intestine in northern Norway , 1978, Cancer.

[9]  Meatheringham Re.  Polyps of colon and rectum. , 1958 .

[10]  F. Ederer,et al.  Maximum utilization of the life table method in analyzing survival. , 1958, Journal of chronic diseases.

[11]  H. Bussey.  Familial polyposis coli. , 1975, Pathology annual.

[12]  Eileen Lovett,et al.  Family studies in cancer of the colon and rectum , 1976, The British journal of surgery.

[13]  T C ARMINSKI,et al.  Incidence and distribution of adenomatous polyps of the colon and rectum based on 1,000 autopsy examinations , 1964, Diseases of the colon and rectum.

[14]  F. Konishi,et al.  Pathology of colorectal adenomas: a colonoscopic survey. , 1982, Journal of clinical pathology.

[15]  S. Moore.  Polyps of the large intestine. , 1951, American journal of surgery.

[16]  Morson Bc,et al.  The Polyp-cancer Sequence in the Large Bowel , 1974 .

[17]  R. Heald,et al.  Clinical experiences at St. Mark’s Hospital with multiple synchronous cancers of the colon and rectum , 1975, Diseases of the colon and rectum.

[18]  T. Muto,et al.  The evolution of cancer of the colon and rectum , 1974, Cancer.

[19]  Silverberg Sg.  Focally malignant adenomatous polyps of the colon and rectum. , 1970 .

[20]  J. Kirsner,et al.  POLYPS OF THE COLON AND RECTUM: A FOUR-YEAR TO NINE-YEAR FOLLOW-UP STUDY OF FIVE HUNDRED THIRTY-SEVEN PATIENTS , 1959 .

[21]  H. Bussey,et al.  Metachronous Carcinoma of the Large Intestine and Intestinal Polyps , 1967, Proceedings of the Royal Society of Medicine.

[22]  C. Fenoglio,et al.  Distribution of human colonic lymphatics in normal, hyperplastic, and adenomatous tissue. Its relationship to metastasis from small carcinomas in pedunculated adenomas, with two case reports. , 1973, Gastroenterology.