Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho

To develop and optimize a multislice glycosaminoglycan (GAG) chemical exchange saturation transfer (GagCEST) sequence for volumetric imaging of articular cartilage, and to validate the sequence against T1ρ relaxation times in whole joint imaging of tibiotalar cartilage.

[1]  Thomas M. Link,et al.  Inter-subject comparison of MRI knee cartilage thickness , 2008, Medical Image Anal..

[2]  Felix Eckstein,et al.  Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis , 2006, NMR in biomedicine.

[3]  H. Genant,et al.  Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. , 2004, Osteoarthritis and cartilage.

[4]  René Rizzoli,et al.  Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). , 2013, Seminars in arthritis and rheumatism.

[5]  Nigel Arden,et al.  Osteoarthritis: epidemiology. , 2006, Best practice & research. Clinical rheumatology.

[6]  V. Mlynárik,et al.  Transverse relaxation mechanisms in articular cartilage. , 2004, Journal of magnetic resonance.

[7]  G. Gold,et al.  Imaging Strategies for Assessing Cartilage Composition in Osteoarthritis , 2014, Current Rheumatology Reports.

[8]  Erik Tryggestad,et al.  Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides , 2010, Nature Medicine.

[9]  Ravinder Reddy,et al.  Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer , 2014, Magnetic resonance in medicine.

[10]  Ravinder R Regatte,et al.  Articular cartilage: evaluation with fluid-suppressed 7.0-T sodium MR imaging in subjects with and subjects without osteoarthritis. , 2013, Radiology.

[11]  Peter Bachert,et al.  Cartilage quality assessment by using glycosaminoglycan chemical exchange saturation transfer and (23)Na MR imaging at 7 T. , 2011, Radiology.

[12]  R S Balaban,et al.  Detection of proton chemical exchange between metabolites and water in biological tissues. , 1998, Journal of magnetic resonance.

[13]  Andrew J Wheaton,et al.  Reduction of residual dipolar interaction in cartilage by spin‐lock technique , 2004, Magnetic resonance in medicine.

[14]  John A. Detre,et al.  Magnetic Resonance Imaging of Glutamate , 2011, Nature Medicine.

[15]  Felix Eckstein,et al.  Imaging in osteoarthritis. , 2008, Rheumatic diseases clinics of North America.

[16]  S. Majumdar,et al.  Longitudinal analysis of MRI T2 knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative: A texture approach , 2011, Magnetic resonance in medicine.

[17]  Arijitt Borthakur,et al.  Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage , 2006, NMR in biomedicine.

[18]  Bennett A Landman,et al.  Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments , 2009, Magnetic resonance in medicine.

[19]  L. Dahlberg,et al.  Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients. , 2009, Osteoarthritis and cartilage.

[20]  Thomas M. Link,et al.  T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients—a 3.0-Tesla MRI study , 2008, European Radiology.

[21]  Ravinder Reddy,et al.  Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T , 2012, Magnetic resonance in medicine.

[22]  Ravinder Reddy,et al.  On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T , 2013, Magnetic resonance in medicine.

[23]  Carl Johan Tiderius,et al.  Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis , 2003, Magnetic resonance in medicine.

[24]  A. Zaninelli,et al.  Osteoarthritis: an overview of the disease and its treatment strategies. , 2005, Seminars in arthritis and rheumatism.

[25]  Nirbhay N. Yadav,et al.  Chemical exchange saturation transfer (CEST): What is in a name and what isn't? , 2011, Magnetic resonance in medicine.

[26]  R. Reddy,et al.  High Resolution T1ρ Mapping of In Vivo Human Knee Cartilage at 7T , 2014, PloS one.

[27]  Gil Navon,et al.  Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) , 2008, Proceedings of the National Academy of Sciences.

[28]  C. Malemud Changes in proteoglycans in osteoarthritis: biochemistry, ultrastructure and biosynthetic processing. , 1991, The Journal of rheumatology. Supplement.

[29]  Ravinder Reddy,et al.  Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications , 2013, Current Radiology Reports.

[30]  A. Borthakur,et al.  Compensation for spin‐lock artifacts using an off‐resonance rotary echo in T1ρoff‐weighted imaging , 2007, Magnetic resonance in medicine.

[31]  Andrew J Wheaton,et al.  Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study. , 2004, Radiology.

[32]  Xiaojuan Li,et al.  Quantitative MRI of articular cartilage and its clinical applications , 2013, Journal of magnetic resonance imaging : JMRI.

[33]  T. Yankeelov,et al.  Optimization of 7-T chemical exchange saturation transfer parameters for validation of glycosaminoglycan and amide proton transfer of fibroglandular breast tissue. , 2015, Radiology.

[34]  D. Canet,et al.  Rotating-frame spin-lattice relaxation time imaging by radio-frequency field gradients: visualization of strained crosslinked natural rubbers. , 2003, Journal of magnetic resonance.