Lemierre’s Syndrome: The Forgotten Disease?

Lemierre’s Syndrome is characterised by a history of recent sore throat, clinical or radiological evidence of internal jugular vein thrombosis and isolation of anaerobic pathogenstypically Fusobacterium necrophorum. Previously considered a forgotten disease due to widespread use of antibiotics for pharyngeal infections, over the past two decades Lemierre’s Syndrome has become an increasingly common presenting complaint. Emergence of antibiotic resistance may explain the recent rise in the number of reported cases. Lemierre’s Syndrome is associated with significant morbidity and mortality if not diagnosed and treated early. In the pre antibiotic era Lemierre’s syndrome was fulminant and fatal in 90% of cases. The classical presentation of Lemierre’s Syndrome is that of an acute oropharyngeal infection in a young otherwise healthy young adult, followed several days later by fever, rigors and associated lung complications. Treatment involves a prolonged course of antibiotics, the role of concomitant anticoagulation still remains controversial. This article describes treatment and management of a patient diagnosed with Lemierre’s syndrome to illustrate its classical presentation, common pitfalls in diagnosis and optimal management. Our aim is to raise awareness amongst clinicians of this potentially fatal but curable disease.

[1]  F. Mechaï,et al.  Lemierre's syndrome: An unusual presentation. , 2015, Medecine et maladies infectieuses.

[2]  C. Rodrigo,et al.  Lemierre's syndrome secondary to community-acquired methicillin-resistant Staphylococcus aureus infection presenting with cardiac tamponade, a rare disease with a life-threatening presentation: a case report , 2014, International Journal of Emergency Medicine.

[3]  I. Morariu,et al.  Lemierre's syndrome, the forgotten disease. , 2014, Irish medical journal.

[4]  M. Kilian,et al.  Molecular Mapping to Species Level of the Tonsillar Crypt Microbiota Associated with Health and Recurrent Tonsillitis , 2013, PloS one.

[5]  Krutika Kuppalli,et al.  Lemierre's syndrome due to Fusobacterium necrophorum. , 2012, The Lancet. Infectious diseases.

[6]  N. Khardori,et al.  Fusobacterium necrophorum – beyond Lemierres syndrome , 2011, BMJ Case Reports.

[7]  T. Wingfield,et al.  Severe pneumonia and jaundice in a young man: an atypical presentation of an uncommon disease. , 2011, Journal of medical microbiology.

[8]  G. Dahlén,et al.  Necrobacillosis in humans , 2011, Expert review of anti-infective therapy.

[9]  J. Prag,et al.  Lemierre’s syndrome and other disseminated Fusobacterium necrophorum infections in Denmark: a prospective epidemiological and clinical survey , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[10]  M. Syed,et al.  Lemierre Syndrome: Two Cases and a Review , 2007, The Laryngoscope.

[11]  J. Vieira,et al.  A Review Of Lemierre Syndrome , 2005 .

[12]  S. Panagea,et al.  Lemierre's syndrome: how a sore throat can end in disaster , 2004, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[13]  T. Riordan,et al.  Lemierre’s syndrome: more than a historical curiosa , 2004, Postgraduate Medical Journal.

[14]  P. Anslow,et al.  Cerebral infarct and meningitis secondary to Lemierre's syndrome. , 2004, Pediatric neurology.

[15]  Y. Sherer,et al.  The changing face of Lemierre's syndrome. , 2003, The Israel Medical Association journal : IMAJ.

[16]  S. Kehl,et al.  Increased diagnosis of Lemierre syndrome and other Fusobacterium necrophorum infections at a Children's Hospital. , 2003, Pediatrics.

[17]  L. Tamariz,et al.  The Evolution of Lemierre Syndrome: Report of 2 Cases and Review of the Literature , 2002, Medicine.

[18]  J. Prag,et al.  Human necrobacillosis, with emphasis on Lemierre's syndrome. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  A. Pinzani,et al.  [Septic thrombophlebitis of the internal jugular vein due to Fusobacterium necrophorum (Lemierre's syndrome): case report and review of literature]. , 1998, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[20]  L. Hagelskjær,et al.  Incidence and clinical epidemiology of necrobacillosis, including Lemierre's syndrome, in Denmark 1990–1995 , 1998, European Journal of Clinical Microbiology and Infectious Diseases.

[21]  E. A. Thornton,et al.  Classification of human and animal strains of Fusobacterium necrophorum by their pathogenic effects in mice. , 1997, Journal of medical microbiology.

[22]  J. Brazier,et al.  A comparative study of Fusobacterium necrophorum strains from human and animal sources by phenotypic reactions, pyrolysis mass spectrometry and SDS-PAGE. , 1997, Journal of medical microbiology.

[23]  A. Blinkhorn,et al.  Possible lethal enhancement of toxins from putative periodontopathogens by nicotine: implications for periodontal disease. , 1997, Journal of clinical pathology.

[24]  A. Macdonald,et al.  Lemierre's syndrome: are we underdiagnosing this life-threatening infection? , 1996, ORL; journal for oto-rhino-laryngology and its related specialties.

[25]  N. Misawa,et al.  Comparison of haemolytic activity between Fusobacterium necrophorum subsp. necrophorum and Fusobacterium necrophorum subsp. funduliforme in vitro and in vivo , 1996, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[26]  R. Clover,et al.  Lemierre Syndrome: Postanginal Sepsis , 1995, The Journal of the American Board of Family Medicine.

[27]  S. Cheung,et al.  Lemierre's Syndrome: Two Cases of Postanginal Sepsis , 1995, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[28]  K. Amoako,et al.  Comparison of extracellular enzymes of Fusobacterium necrophorum subsp. necrophorum and Fusobacterium necrophorum subsp. funduliforme , 1993, Journal of clinical microbiology.

[29]  P. Fardy,et al.  The Lemierre Syndrome: Suppurative Thrombophlebitis of the Internal Jugular Vein Secondary to Oropharyngeal Infection , 1989, Medicine.

[30]  E. Bouza,et al.  Lemierre's disease: postanginal bacteremia and pulmonary involvement caused by Fusobacterium necrophorum. , 1989, Reviews of infectious diseases.

[31]  S. Gilman,et al.  The role of anticoagulation in cavernous sinus thrombosis , 1988, Neurology.

[32]  R. Dagan,et al.  Postanginal sepsis following infectious mononucleosis. , 1987, Archives of internal medicine.

[33]  J. Luby,et al.  Fusobacterium necrophorum septicemia following oropharyngeal infection. , 1982, JAMA.

[34]  A. Lemierre ON CERTAIN SEPTICÆMIAS DUE TO ANAEROBIC ORGANISMS , 1936 .

[35]  B. Wong,et al.  Lemierre syndrome: a pediatric case series and review of literature. , 2010, American journal of otolaryngology.

[36]  M. Gazagnes,et al.  [Lemierre's syndrome]. , 2010, Annales francaises d'anesthesie et de reanimation.

[37]  A. Alherabi A case of Lemierre syndrome , 2009, Annals of Saudi medicine.

[38]  H. Nguyen,et al.  [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. , 1996, Deutsche medizinische Wochenschrift.

[39]  I. C. Tuna,et al.  Septic pulmonary emboli complicating mastoiditis: Lemierre's syndrome revisited. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[40]  E. Carlson,et al.  Lemierre's syndrome: two cases of a forgotten disease. , 1994, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[41]  A. D. De Schepper,et al.  Three cases of Fusobacterium necrophorum septicemia. , 1993, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.