Associations between Electrocardiographic Interval Durations and Coronary Artery Calcium Scores: The Diabetes Heart Study

Background: The mechanisms underlying the associations between QT interval duration and risk of cardiovascular disease (CVD) remain unclear. It has been assumed that these associations are driven by abnormal myocardial repolarization. We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants.

[1]  H. Ishwaran,et al.  Quantitative Measures of Electrocardiographic Left Ventricular Mass, Conduction, and Repolarization, and Long-Term Survival After Coronary Artery Bypass Grafting , 2007, Circulation.

[2]  M. Nieminen,et al.  Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE Study , 2007, Journal of hypertension.

[3]  E. Perrier,et al.  Non-invasive detection of coronary artery disease in patients with left bundle branch block using 64-slice computed tomography. , 2006, Journal of the American College of Cardiology.

[4]  A. Keren,et al.  The value of changes in QRS width and in ST-T segment during exercise test in hypertrophic cardiomyopathy for identification of associated coronary artery disease. , 2006, International journal of cardiology.

[5]  R. Detrano,et al.  Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis). , 2006, Journal of the American College of Cardiology.

[6]  Takuya Yamazaki,et al.  Prognostic Significance of Quantitative Qrs Duration , 2022 .

[7]  M. Das,et al.  Significance of a Fragmented QRS Complex Versus a Q Wave in Patients With Coronary Artery Disease , 2006, Circulation.

[8]  G. Schmidt,et al.  QRS duration and late mortality in unselected post-infarction patients of the revascularization era. , 2006, European heart journal.

[9]  O. Pahlm,et al.  Left ventricular mass by 12-lead electrocardiogram in healthy subjects: comparison to cardiac magnetic resonance imaging. , 2006, Journal of electrocardiology.

[10]  P. Pellikka,et al.  Relation of QRS duration on the surface 12-lead electrocardiogram with mortality in patients with known or suspected coronary artery disease. , 2005, The American journal of cardiology.

[11]  P. Nourjah,et al.  Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey , 2005, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[12]  D. Levy,et al.  Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study. , 2005, Journal of the American College of Cardiology.

[13]  R. Detrano,et al.  Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. , 2005, Radiology.

[14]  Y. Aso,et al.  Association between the corrected QT intervals and combined intimal-medial thickness of the carotid artery in patients with type 2 diabetes. , 2004, Metabolism: clinical and experimental.

[15]  A. Folsom,et al.  Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. , 2004, Journal of the American College of Cardiology.

[16]  J. Robbins,et al.  The association between the length of the QT interval and mortality in the Cardiovascular Health Study. , 2003, The American journal of medicine.

[17]  G. Salles,et al.  Prognostic value of QT interval parameters in type 2 diabetes mellitus: results of a long-term follow-up prospective study. , 2003, Journal of diabetes and its complications.

[18]  H. Janka,et al.  Prolonged QTc interval and elevated heart rate identify the type 2 diabetic patient at high risk for cardiovascular death. The Bremen Diabetes Study. , 2003, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[19]  S. Anker,et al.  Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration. , 2002, International journal of cardiology.

[20]  Charles Kooperberg,et al.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. , 2002, JAMA.

[21]  S. Fisher,et al.  QRS duration and mortality in patients with congestive heart failure. , 2002, American heart journal.

[22]  G. Bruno,et al.  Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population‐based cohort , 2002, Journal of internal medicine.

[23]  W. Edwards,et al.  Estrogen status correlates with the calcium content of coronary atherosclerotic plaques in women. , 2002, The Journal of clinical endocrinology and metabolism.

[24]  R. Halmosi,et al.  QRS Score: A Composite Index of Exercise‐Induced Changes in the Q, R, and S Waves During Exercise Stress Testing in Patients with Ischemic Heart Disease , 2001, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[25]  C. Langefeld,et al.  Familial aggregation of coronary artery calcium in families with type 2 diabetes. , 2001, Diabetes.

[26]  M. Lauer,et al.  Complete bundle branch block as an independent predictor of all-cause mortality: report of 7,073 patients referred for nuclear exercise testing. , 2001, The American journal of medicine.

[27]  M. Rewers,et al.  Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS). , 1999, Stroke.

[28]  J A Kors,et al.  Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study. , 1999, European heart journal.

[29]  A. T. N. Group,et al.  The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group , 1999, Diabetologia.

[30]  P M Rautaharju,et al.  The Novacode criteria for classification of ECG abnormalities and their clinically significant progression and regression. , 1998, Journal of electrocardiology.

[31]  R. Seibel,et al.  Comparison of electron beam computed tomography with intracoronary ultrasound and coronary angiography for detection of coronary atherosclerosis. , 1997, Journal of the American College of Cardiology.

[32]  J. P. Bacon,et al.  Exercise-induced QRS changes (Athens QRS score) in patients with coronary artery disease: a marker of myocardial ischemia. , 1995, Journal of cardiology.

[33]  P. Kligfield,et al.  Gender differences and the electrocardiogram in left ventricular hypertrophy. , 1995, Hypertension.

[34]  A. Wilde,et al.  Myocardial potassium loss and cell depolarisation in ischaemia and hypoxia. , 1995, Cardiovascular research.

[35]  M A Proschan,et al.  Coronary artery calcification: assessment with electron beam CT and histomorphometric correlation. , 1994, Radiology.

[36]  D Kromhout,et al.  Association Between QT Interval and Coronary Heart Disease in Middle‐aged and Elderly Men: The Zutphen Study , 1994, Circulation.

[37]  J. Vandenbroucke,et al.  QT Interval Prolongation Predicts Cardiovascular Mortality in an Apparently Healthy Population , 1991, Circulation.

[38]  L. Reuss,et al.  Protamine alters apical membrane K+ and Cl- permeability in gallbladder epithelium. , 1987, The American journal of physiology.

[39]  K. Lurie,et al.  Metabolism and electrophysiology in subendocardial Purkinje fibers after infarction. , 1987, American Journal of Physiology.

[40]  V. Froelicher,et al.  Computer analysis of exercise-induced changes in QRS duration in patients with angina pectoris and in normal subjects. , 1986, American heart journal.

[41]  K Y Liang,et al.  Longitudinal data analysis for discrete and continuous outcomes. , 1986, Biometrics.

[42]  P. Ursell,et al.  Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. , 1985, Circulation.

[43]  P. Ursell,et al.  Structural and Electrophysiological Changes in the Epicardial Border Zone of Canine Myocardial Infarcts during Infarct Healing , 1985, Circulation research.

[44]  A. Marty.  Minnesota Code Manual of Electrocardiographic Findings , 1983 .

[45]  J. Spear,et al.  Cellular electrophysiologic characteristics of chronically infarcted myocardium in dogs susceptible to sustained ventricular tachyarrhythmias. , 1983, Journal of the American College of Cardiology.

[46]  M J Janse,et al.  Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia. , 1981, Circulation research.

[47]  W. Kannel,et al.  Newly acquired left bundle-branch block: the Framingham study. , 1979, Annals of internal medicine.

[48]  A. L. Wit,et al.  Time Course for Reversal of Electrophysiological and Ultrastructural Abnormalities in Subendocardial Purkinje Fibers Surviving Extensive Myocardial Infarction in Dogs , 1975, Circulation research.

[49]  H. Bazett,et al.  AN ANALYSIS OF THE TIME‐RELATIONS OF ELECTROCARDIOGRAMS. , 1997 .