Progressive cerebral atrophy in MS: A serial study using registered, volumetric MRI

reinforced when AEDs (mainly carbamazepine, phenytoin, and medications increasing cerebral levels of GABA) control seizures, and on the contrary, may regress after cessation of any AED or substitution of polytherapy by benzodiazepine monotherapy. Taken together, these data suggest that atypical evolutions might be iatrogenic conditions.5,6 In cases similar to those presented by Ong and Wyllie, the incapacitating clonic/atonic symptoms may correspond to interictal events aggravated by overmedication with contraindicated AEDs, rather than to seizures resistant to therapy.

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