Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment

Aim:  There is little evidence that dehydroepiandrosterone (DHEA) has beneficial effects on physical and psychological functions in older women. We investigated the effect of DHEA supplementation on cognitive function and ADL in older women with cognitive impairment.

[1]  F. Mahoney,et al.  FUNCTIONAL EVALUATION: THE BARTHEL INDEX. , 2018, Maryland state medical journal.

[2]  Katsuya Iijima,et al.  Association of plasma sex hormone levels with functional decline in elderly men and women , 2009, Geriatrics & gerontology international.

[3]  H. Arai,et al.  Clinical effects of high oral dose of donepezil for patients with Alzheimer's disease in Japan , 2009, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

[4]  D. V. von Mühlen,et al.  Effects of Dehydroepiandrosterone Supplementation on Cognitive Function and Quality of Life: The DHEA and Well‐Ness (DAWN) Trial , 2008, Journal of the American Geriatrics Society.

[5]  J. Kulkarni,et al.  Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. , 2008, The Journal of clinical endocrinology and metabolism.

[6]  N. Goldman,et al.  Sex differences in the relationship between DHEAS and health , 2007, Experimental Gerontology.

[7]  Andrea Riccardo Genazzani,et al.  Estrogen, cognition and female ageing. , 2007, Human reproduction update.

[8]  Claudio Cobelli,et al.  DHEA in elderly women and DHEA or testosterone in elderly men. , 2006, The New England journal of medicine.

[9]  T. Travison,et al.  Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study. , 2006, The Journal of clinical endocrinology and metabolism.

[10]  J. Janowsky,et al.  Thinking with your gonads: testosterone and cognition , 2006, Trends in Cognitive Sciences.

[11]  R. Prough,et al.  The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors , 2006, Drug metabolism reviews.

[12]  J. Kaufman,et al.  The decline of androgen levels in elderly men and its clinical and therapeutic implications. , 2005, Endocrine reviews.

[13]  S. Davis,et al.  Androgen levels in adult females: changes with age, menopause, and oophorectomy. , 2005, The Journal of clinical endocrinology and metabolism.

[14]  Robert W Platt,et al.  A longitudinal study of dehydroepiandrosterone sulphate (DHEAS) change in older men and women: the Rancho Bernardo Study. , 2004, European journal of endocrinology.

[15]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[16]  L. Thal,et al.  Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study , 2004, JAMA.

[17]  JoAnn E Manson,et al.  Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. , 2004, JAMA.

[18]  S. Bandinelli,et al.  Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  D. Fuchs,et al.  DHEA treatment of Alzheimer’s disease: A randomized, double-blind, placebo-controlled trial , 2004, Neurology.

[20]  D. Budescu,et al.  Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women , 2004, Hormones and Behavior.

[21]  Robert B Wallace,et al.  Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. , 2003, JAMA.

[22]  E. Baulieu,et al.  Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial. , 2003, Archives of internal medicine.

[23]  Y. Ouchi,et al.  Vitality Index as a useful tool to assess elderly with dementia , 2002 .

[24]  W. Mayo,et al.  Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging , 2001, Brain Research Reviews.

[25]  M. Fassnacht,et al.  Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. , 2001, The Journal of clinical endocrinology and metabolism.

[26]  H. Feldman,et al.  A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease , 2001, Neurology.

[27]  Dirk Deleu,et al.  A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. , 2001, Neurology.

[28]  J. Simard,et al.  DHEA and Its Transformation into Androgens and Estrogens in Peripheral Target Tissues: Intracrinology , 2001, Frontiers in Neuroendocrinology.

[29]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[30]  G. Rodriguez,et al.  Hippocampal Perfusion and Pituitary-Adrenal Axis in Alzheimer’s Disease , 2000, Neuropsychobiology.

[31]  K. Barnhart,et al.  The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. , 2000, The Journal of clinical endocrinology and metabolism.

[32]  E. Ferrari,et al.  Association between Changes in Adrenal Secretion and Cerebral Morphometric Correlates in Normal Aging and Senile Dementia , 2000, Dementia and Geriatric Cognitive Disorders.

[33]  F. Reischies,et al.  DHEA-S plasma levels and incidence of Alzheimer’s disease , 2000, Biological Psychiatry.

[34]  K. Barnhart,et al.  The effect of deydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life , 1999 .

[35]  S. Sakoda,et al.  The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia , 1999, Journal of the Neurological Sciences.

[36]  R. Haubrich,et al.  The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women , 1998, Clinical endocrinology.

[37]  Dirk H. Hellhammer,et al.  OPPOSING EFFECTS OF DHEA REPLACEMENT IN ELDERLY SUBJECTS ON DECLARATIVE MEMORY AND ATTENTION AFTER EXPOSURE TO A LABORATORY STRESSOR , 1998, Psychoneuroendocrinology.

[38]  R. Mohs,et al.  A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease , 1998, Neurology.

[39]  C. Kirschbaum,et al.  Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. , 1997, The Journal of clinical endocrinology and metabolism.

[40]  N. Orentreich,et al.  Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. , 1984, The Journal of clinical endocrinology and metabolism.

[41]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[42]  E. Fels.  [Androgen therapy in women]. , 1950, Prensa medica argentina.

[43]  F. Petraglia,et al.  Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women. , 1999, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[44]  P A Parmelee,et al.  Geriatric Depression Scale , 2002 .

[45]  F. I. Mahonery.  Functional evaluation : Barthel index , 1965 .