Twin studies of eating disorders: a review.

OBJECTIVE Twin methodology has been used to delineate etiological factors in many medical disorders and behavioral traits including eating disorders. Although twin studies are powerful tools, their methodology can be arcane and their implications easily misinterpreted. METHOD The goals of this study are to (a) review the theoretical rationale for twin studies; (b) provide a framework for their interpretation and evaluation; (c) review extant twin studies on eating disorders; and (d) explore the implications for understanding etiological issues in eating disorders. DISCUSSION On the basis of this review, it is not possible to draw firm conclusions regarding the precise contribution of genetic and environmental factors to anorexia nervosa. Twin studies confirm that bulimia nervosa is familial and reveal significant contributions of additive genetic effects and of unique environmental factors in liability to bulimia nervosa. The magnitude of the contribution of shared environment is less clear, but in the studies with the greatest statistical power, it appears to be less prominent than additive genetic factors.

[1]  Karl Pearson,et al.  Mathematical contributions to the theory of evolution. VIII. On the correlation of characters not quantitatively measurable , 1900, Proceedings of the Royal Society of London.

[2]  J BERKSON,et al.  Limitations of the application of fourfold table analysis to hospital data. , 1946, Biometrics.

[3]  J. Church,et al.  Childhood and Adolescence , 1959 .

[4]  E. M. Russell Cerebral Palsied Twins , 1961, Archives of disease in childhood.

[5]  D. Falconer The inheritance of liability to certain diseases, estimated from the incidence among relatives , 1965 .

[6]  E. Kringlen Heredity and Environment in the Functional Psychoses. An Epidemiological-Clinical Twin Study , 1968 .

[7]  S. Scarr,et al.  Environmental bias in twin studies. , 1968, Eugenics quarterly.

[8]  Jacob Cohen Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[9]  J. Harmatz,et al.  Alcoholism in women. , 1971, Archives of general psychiatry.

[10]  Robert C. Nichols,et al.  Heredity, Environment, and Personality: A Study of 850 Sets of Twins , 1976 .

[11]  S. Folstein,et al.  Infantile autism: a genetic study of 21 twin pairs. , 1977, Journal of child psychology and psychiatry, and allied disciplines.

[12]  Lindon J. Eaves,et al.  Inferring the Causes of Human Variation , 1977 .

[13]  N. Martin,et al.  The power of the classical twin study , 1978, Heredity.

[14]  R. Naeye,et al.  Twins: causes of perinatal death in 12 United States cities and one African city. , 1978, American journal of obstetrics and gynecology.

[15]  A. Tellegen,et al.  Volunteer bias in twin research: the rule of two-thirds. , 1978, Social biology.

[16]  F. Askevold,et al.  Anorexia nervosa--two cases in discordant MZ twins. , 1979, Psychotherapy and psychosomatics.

[17]  J. Kaprio,et al.  A cross-national epidemiological resource: the Swedish and Finnish cohort studies of like-sexed twins. , 1982, International Journal of Epidemiology.

[18]  K. Kendler,et al.  Overview: a current perspective on twin studies of schizophrenia. , 1983, The American journal of psychiatry.

[19]  Nowlin Ns Anorexia Nervosa in twins: case report and review. , 1983 .

[20]  A. Holland,et al.  Anorexia Nervosa: A Study of 34 Twin Pairs and One Set of Triplets , 1984, British Journal of Psychiatry.

[21]  D. Fulker,et al.  Multiple regression analysis of twin data , 1985, Behavior genetics.

[22]  K. Kendler,et al.  Recurrence risks in an oligogenic threshold model: the effect of alterations in allele frequency , 1986, Annals of human genetics.

[23]  L. Humphrey Family relations in bulimic‐anorexic and nondistressed families , 1986 .

[24]  L J Eaves,et al.  Models for the joint effect of genotype and environment on liability to psychiatric illness. , 1986, The American journal of psychiatry.

[25]  C Loehlin John,et al.  Latent variable models: an introduction to factor, path, and structural analysis , 1986 .

[26]  D. Yurgelun-Todd,et al.  A controlled family history study of bulimia , 1987, Psychological Medicine.

[27]  H. Akaike Factor analysis and AIC , 1987 .

[28]  R. Plomin,et al.  Why are children in the same family so different from one another? , 1987, Behavioral and Brain Sciences.

[29]  A. Holland,et al.  Anorexia nervosa: evidence for a genetic basis. , 1988, Journal of psychosomatic research.

[30]  E. Gershon,et al.  Psychiatric disorders in the first-degree relatives of probands with bulimia nervosa. , 1989, The American journal of psychiatry.

[31]  J K Hewitt,et al.  Testing structural equation models for twin data using LISREL , 1989, Behavior genetics.

[32]  K. Kendler,et al.  The estimation of probandwise concordance in twins: the effect of unequal ascertainment. , 1989, Acta geneticae medicae et gemellologiae.

[33]  Hans J. Eysenck,et al.  Genes, culture, and personality : an empirical approach , 1989 .

[34]  P. Joyce,et al.  Prevalence of three bulimia syndromes in the general population , 1990, Psychological Medicine.

[35]  M. Fichter,et al.  Concordance for bulimia nervosa in twins , 1990 .

[36]  R. Plomin,et al.  Separate Lives: Why Siblings Are So Different , 1990 .

[37]  L. Hsu,et al.  Bulimia nervosa in eleven sets of twins a clinical report , 1990 .

[38]  H. Hoek,et al.  The incidence and prevalence of anorexia nervosa and bulimia nervosa in primary care , 1991, Psychological Medicine.

[39]  R. Kessler,et al.  The genetic epidemiology of bulimia nervosa. , 1991, The American journal of psychiatry.

[40]  R. Kessler,et al.  A population-based twin study of alcoholism in women. , 1992, JAMA.

[41]  C. Johanson,et al.  Craving: consensus of status and agenda for future research. , 1992, Drug and alcohol dependence.

[42]  M. McGue,et al.  Sex and age effects on the inheritance of alcohol problems: a twin study. , 1992, Journal of abnormal psychology.

[43]  J. Crowther,et al.  The Etiology of bulimia nervosa : the individual and familial context , 2013 .

[44]  C. Fairburn,et al.  Binge eating: nature, assessment and treatment , 1993 .

[45]  Michael C. Neale,et al.  A test of the equal-environment assumption in twin studies of psychiatric illness , 1993, Behavior genetics.

[46]  J. S. Long,et al.  Testing Structural Equation Models , 1993 .

[47]  R. Murray,et al.  Genetic influences on eating attitudes in a normal female twin population , 1993, Psychological Medicine.

[48]  K. Kendler,et al.  Twin studies of psychiatric illness. Current status and future directions. , 1993, Archives of general psychiatry.

[49]  R. Garfinkel,et al.  Childhood abuse, family environment, and outcome in bulimia nervosa. , 1994, The Journal of clinical psychiatry.

[50]  P. Joyce,et al.  Bulimia comorbidity in the general population and in the clinic , 1994, Psychological Medicine.

[51]  R. Kessler,et al.  Parental treatment and the equal environment assumption in twin studies of psychiatric illness , 1994, Psychological Medicine.

[52]  Larry J. Williams,et al.  Parsimony‐based fit indices for multiple‐indicator models: Do they work? , 1994 .

[53]  M C Neale,et al.  The power of the classical twin study to resolve variation in threshold traits , 1994, Behavior genetics.

[54]  M. Rutter,et al.  The application of structural equation modeling to maternal ratings of twins' behavioral and emotional problems. , 1994, Journal of consulting and clinical psychology.

[55]  P. Sham,et al.  Logistic regression analysis of twin data: Estimation of parameters of the multifactorial liability-threshold model , 1994, Behavior genetics.

[56]  P. Garfinkel,et al.  Family interactions in bulimia nervosa. II: Complex intrafamily comparisons and clinical significance. , 1995, The International journal of eating disorders.

[57]  D S Goldbloom,et al.  Bulimia nervosa in a Canadian community sample: prevalence and comparison of subgroups. , 1995, The American journal of psychiatry.

[58]  K. Kendler,et al.  Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample. , 1995, The American journal of psychiatry.

[59]  P. Garfinkel,et al.  Family interactions in bulimia nervosa. I: Study design, comparisons to established population norms, and changes over the course of an intensive day hospital treatment program. , 1995, The International journal of eating disorders.

[60]  R. Kessler,et al.  The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. , 1995, Archives of general psychiatry.

[61]  M C Neale,et al.  Physical similarity and the equal-environment assumption in twin studies of psychiatric disorders , 1995, Behavior genetics.

[62]  P. A. Norman,et al.  Bias and bulimia nervosa: how typical are clinic cases? , 1996, The American journal of psychiatry.

[63]  K. Kendler,et al.  The treated incidence of psychotic and affective illness in twins compared with population expectation: a study in the Swedish Twin and Psychiatric Registries , 1996, Psychological Medicine.

[64]  M. Rutter,et al.  Opportunities for psychiatry from genetic findings , 1997, British Journal of Psychiatry.

[65]  A. Heath,et al.  A Comparison of the Eating Disorder Examination and a General Psychiatric Schedule , 1997, The Australian and New Zealand journal of psychiatry.

[66]  N. Martin,et al.  A twin-pronged attack on complex traits , 1997, Nature Genetics.

[67]  D W Fulker,et al.  Increase in Power through Multivariate Analyses , 1998, Behavior genetics.

[68]  Genetics of autism , 1998 .

[69]  P. Sullivan,et al.  Heritability of binge-eating and broadly defined bulimia nervosa , 1998, Biological Psychiatry.

[70]  P. Sullivan,et al.  The epidemiology and classification of bulimia nervosa , 1998, Psychological Medicine.

[71]  N. Martin,et al.  Genetic and environmental risk factors for the weight and shape concerns characteristic of bulimia nervosa , 1998, Psychological Medicine.

[72]  K. Kendler,et al.  Cannabis use, abuse, and dependence in a population-based sample of female twins. , 1998, The American journal of psychiatry.

[73]  R Derom,et al.  Validation of a Telephone Zygosity Questionnaire in Twins of Known Zygosity , 1998, Behavior genetics.

[74]  M Strober,et al.  A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. , 1998, Archives of general psychiatry.

[75]  K. Kendler,et al.  Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence? , 1998, Psychological Medicine.

[76]  P. Sullivan,et al.  Genetic epidemiology of binging and vomiting , 1998, British Journal of Psychiatry.

[77]  N. Martin,et al.  A Genetic Analysis of the Eating and Attitudes Associated with Bulimia Nervosa: Dealing with the Problem of Ascertainment in Twin Studies , 1999, Behavior genetics.

[78]  Paul J. Harrison,et al.  Twin studies and the etiology of eating disorders. , 1999, The International journal of eating disorders.

[79]  K. Kendler,et al.  Anorexia nervosa and major depression: shared genetic and environmental risk factors. , 2000, The American journal of psychiatry.

[80]  W. Iacono,et al.  Age differences in genetic and environmental influences on eating attitudes and behaviors in preadolescent and adolescent female twins. , 2000, Journal of abnormal psychology.

[81]  W. Iacono,et al.  Physical Similarity and Twin Resemblance for Eating Attitudes and Behaviors: A Test of the Equal Environments Assumption , 2000, Behavior genetics.

[82]  K. Kendler Twin Studies of Psychiatric Illness , 2001 .