LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice.

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). beta 2-Microglobulin-deficient mice (beta 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When beta 2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

[1]  R. Jaenisch,et al.  Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells , 1991, The Journal of experimental medicine.

[2]  J. McCluskey,et al.  Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Frelinger,et al.  Production and characterization of a peptide specific, anti-major histocompatibility complex class II, monoclonal antibody. , 1991, Molecular immunology.

[4]  S. Weiss,et al.  MHC class II—Restricted presentation of intracellular antigen , 1991, Cell.

[5]  R. Zinkernagel,et al.  Vaccination for disease. , 1991, Science.

[6]  K. Rock,et al.  Presentation of exogenous antigen with class I major histocompatibility complex molecules. , 1990, Science.

[7]  A. Huang,et al.  The soluble viral glycoprotein of vesicular stomatitis virus efficiently sensitizes target cells for lysis by CD4+ T lymphocytes , 1990, Journal of virology.

[8]  P. Marrack,et al.  Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. , 1990, Science.

[9]  J. Frelinger,et al.  Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition. , 1990, Cellular immunology.

[10]  R. Jaenisch,et al.  β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells , 1990, Nature.

[11]  F. Ognibene,et al.  CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. , 1989, Annals of internal medicine.

[12]  A. Osterhaus,et al.  Measles virus-specific human T cell clones. Characterization of specificity and function of CD4+ helper/cytotoxic and CD8+ cytotoxic T cell clones. , 1989, Journal of immunology.

[13]  R. Horton,et al.  Structural relationships among the H-2 D-regions of murine MHC haplotypes. , 1989, Journal of immunology.

[14]  M. Gething,et al.  Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes , 1987, Immunological reviews.

[15]  D. Moskophidis,et al.  Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response , 1987, Journal of virology.

[16]  B. Mach,et al.  Rapid A Defect in the Regulation of Major Histocompatibility Complex Class 11 Gene Expression in Human HLA-DR Negative Lymphocytes from Patients with Combined Immunodeficiency Syndrome , 2022 .

[17]  J. Lowenthal,et al.  Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells , 1985, Nature.

[18]  T. Braciale,et al.  Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products. , 1984, Cellular immunology.

[19]  M. Yasukawa,et al.  Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens. , 1984, Journal of immunology.

[20]  R. Ahmed,et al.  Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants. , 1984, Journal of immunology.

[21]  K. Ozato,et al.  Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression. , 1981, Journal of immunology.

[22]  A. Glasebrook,et al.  IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. , 1980, Journal of immunology.

[23]  N. Nathanson,et al.  Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease , 1972, Nature.

[24]  R. Zinkernagel,et al.  Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes—a model for MHC/disease associations , 1985, Nature.

[25]  M. Buchmeier,et al.  The virology and immunobiology of lymphocytic choriomeningitis virus infection. , 1980, Advances in immunology.

[26]  T. Potter,et al.  Murine lymphocyte surface antigens. , 1979, Advances in immunology.

[27]  J. Hotchin.  The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. , 1962, Cold Spring Harbor symposia on quantitative biology.