Characteristics of the stimulatory effect of kisspeptin-10 on the secretion of luteinizing hormone, follicle-stimulating hormone and growth hormone in prepubertal male and female cattle.

The aims of the present study were to clarify the effect of kisspeptin-10 (Kp10) on the secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and growth hormone (GH) in prepubertal male and female cattle. The experiments were performed from May to June using five male (4-6 months old) and five female (5-6 months old) Japanese Black calves. A single intravenous (iv) injection of Kp10 (5 microg/kg body weight (b.w.): 3.85 nmol/ kg b.w.) significantly stimulated the release of LH and FSH in male and female calves (P<0.05). A single intramuscular injection of Kp10 (5 microg/kg b.w.) also significantly stimulated the release of LH and FSH in male calves (P<0.05), though the response was smaller than that to the iv injection. The injection of Kp10 did not alter the basal plasma concentration of GH in male or female calves. The area under the curve (AUC) of both LH and FSH for a 120-min period after the iv injection of Kp10 was significantly greater in the males than females (P<0.05). These results show that Kp10 can stimulate the release of LH and FSH in calves of both sexes and that the response to the peptide is greater in males at this age. They also show that Kp10 has no effect on the release of GH in male and female calves and that the LH- and FSH-releasing effect of Kp10 is greater after an iv injection than after an im injection in calves.

[1]  T. Yamashita,et al.  Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats. , 2010, Animal reproduction science.

[2]  R. Steiner,et al.  From KISS1 to kisspeptins: An historical perspective and suggested nomenclature , 2009, Peptides.

[3]  B. Whitlock,et al.  Interaction of Estrogen and Progesterone on Kisspeptin-10-Stimulated Luteinizing Hormone and Growth Hormone in Ovariectomized Cows , 2008, Neuroendocrinology.

[4]  I. Franceschini,et al.  Basic aspects of the control of GnRH and LH secretions by kisspeptin: potential applications for better control of fertility in females. , 2008, Reproduction in domestic animals = Zuchthygiene.

[5]  C. Barb,et al.  Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts. , 2008, Reproduction.

[6]  S. Suzuki,et al.  Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells. , 2008, Animal reproduction science.

[7]  J. T. Smith,et al.  Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. , 2008, Endocrinology.

[8]  A. Miyamoto,et al.  Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers. , 2008, The Journal of endocrinology.

[9]  S. Suzuki,et al.  Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. , 2008, Animal reproduction science.

[10]  C. Clay,et al.  KiSS-1 peptide induces release of LH by a direct effect on the hypothalamus of ovariectomized ewes. , 2007, Animal reproduction science.

[11]  S. Bloom,et al.  Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. , 2007, The Journal of clinical endocrinology and metabolism.

[12]  A. Martínez-Fuentes,et al.  Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion , 2007, Journal of neuroendocrinology.

[13]  H. Matsumoto,et al.  Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. , 2007, The Journal of reproduction and development.

[14]  R. Steiner,et al.  Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. , 2006, Reproduction.

[15]  S. Bloom,et al.  Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. , 2005, The Journal of clinical endocrinology and metabolism.

[16]  R. Braun,et al.  Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. , 2005, Endocrinology.

[17]  F. Casanueva,et al.  Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. , 2005, Endocrinology.

[18]  S. Ojeda,et al.  Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[19]  D. Ma,et al.  Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Sánchez-Criado,et al.  Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. , 2004, Endocrinology.

[21]  J. T. Smith,et al.  A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse Materials and Methods Animals and Chemicals , 2022 .

[22]  H. Matsumoto,et al.  Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. , 2004, Biochemical and biophysical research communications.

[23]  M. Lucy.  Regulation of ovarian follicular growth by somatotropin and insulin-like growth factors in cattle. , 2000, Journal of dairy science.

[24]  Y. Takahashi,et al.  Plasma Profiles of Growth Hormone, Prolactin and Insulin-like Growth Factor-I during Gestation, Lactation and the Neonatal Period in Goats , 1999 .

[25]  R. Wood,et al.  GnRH neurons in the fetal lamb hypothalamus are similar in males and females. , 1992, Neuroendocrinology.

[26]  W. Chin,et al.  Molecular biology of the pituitary gonadotropins. , 1990, Endocrine reviews.

[27]  S. Kanematsu,et al.  Effect of cholecystokinin on luteinizing hormone release from perifused hypothalamus-pituitary in castrated bulls. , 1990 .

[28]  S. Taleisnik,et al.  Release of luteinizing hormone induced by estrogen injection into ovariectomized rats. , 1971, Endocrinology.