Corticosteroid-induced myopathy and the respiratory muscles. Report of two cases.

Two women with connective tissue disease developed a characteristic steroid-induced myopathy. Reduced maximal transrespiratory pressures indicated reduced respiratory muscle strength. Gradual steroid dosage tapering resulted in prompt clinical improvement and marked increases in respiratory muscle strength, maximal inspiratory pressure increasing by 33 percent in one patient and by 70 percent in the other. This reversible steroid-induced respiratory muscle weakness may be of great significance in reconsidering long-term steroid therapy in patients with underlying lung disease.

[1]  P. Macklem,et al.  The respiratory muscles. , 1982, The New England journal of medicine.

[2]  P. Macklem,et al.  The respiratory muscles: mechanics, control, and pathophysiology. Part III. , 1978, The American review of respiratory disease.

[3]  R. Moskowitz,et al.  Steroid myopathy in connective tissue disease. , 1976, The American journal of medicine.

[4]  P. Vignos,et al.  Experimental corticosteroid myopathy. , 1969, Arthritis and rheumatism.

[5]  Bergman Ra,et al.  Steroid myopathy. Clinical, histologic and cytologic observations. , 1968 .

[6]  G. Faludi,et al.  Factors influencing the development of steroid-induced myopathies. , 1966, Annals of the New York Academy of Sciences.

[7]  J. Luce,et al.  Respiratory muscle function in health and disease. , 1982, Chest.

[8]  G. Faludi,et al.  EFFECT OF STEROIDS ON MUSCLE. , 1964, Acta endocrinologica.

[9]  S. M. Murray,et al.  Corticosteroid myopathy. , 1961, Annals of physical medicine.