Length of stay prediction for clinical treatment process using temporal similarity

In clinical treatment processes, inpatient length of stay (LOS) is not only a readily available indicator of hospital activity, but also a reasonable proxy of resource consumption. Accurate inpatient LOS prediction has strong implications for health service delivery. Major techniques proposed (statistical approaches or artificial neuronal networks) consider a priori knowledge, such as demographics or patient physical factors, providing accurate methods to estimate LOS at early stages of the patient (admission). However, unexpected scenarios and variations are commonplaces of clinical treatment processes that have a dramatical impact on the LOS. Therefore, these predictors should deal with adaptability, considering the temporal evolution of the patient. In this paper, we propose an inpatient LOS prediction approach across various stages of clinical treatment processes. This proposal relies on a kind of regularity assumption demanding that patient traces of the specific treatment process with similar medical behaviors have similar LOS. Therefore, this approach follows a Case-based Reasoning methodology since it predicts an inpatient LOS of a partial patient trace by referring to the past traces of clinical treatment processes that have similar medical behaviors with the current one. The proposal is evaluated using 284 patient traces from the pulmonary infection CTPs, extracted from Zhejiang Huzhou Central Hospital of China.

[1]  Keiko Abe,et al.  Variance analysis of a clinical pathway of video-assisted single lobectomy for lung cancer , 2009, Surgery Today.

[2]  D Stangl,et al.  Assessing The Impact of Managed-Care on the Distribution of Length-of-Stay Using Bayesian Hierarchical Models , 2000, Lifetime data analysis.

[3]  Chih-Ping Wei,et al.  Predicting the length of hospital stay of burn patients: Comparisons of prediction accuracy among different clinical stages , 2010, Decis. Support Syst..

[4]  Francesco Folino,et al.  Mining usage scenarios in business processes: Outlier-aware discovery and run-time prediction , 2011, Data Knowl. Eng..

[5]  M. Wong,et al.  Burns mortality and hospitalization time--a prospective statistical study of 352 patients in an Asian National Burn Centre. , 1995, Burns : journal of the International Society for Burn Injuries.

[6]  Carlo Combi,et al.  Data mining with Temporal Abstractions: learning rules from time series , 2007, Data Mining and Knowledge Discovery.

[7]  Asha Seth Kapadia,et al.  Predicting duration of stay in a pediatric intensive care unit: A Markovian approach , 2000, Eur. J. Oper. Res..

[8]  Andy H. Lee,et al.  Finite mixture regression model with random effects: application to neonatal hospital length of stay , 2003, Comput. Stat. Data Anal..

[9]  Heikki Mannila,et al.  Similarity between Event Types in Sequences , 1999, DaWaK.

[10]  Huilong Duan,et al.  Variation Prediction in Clinical Processes , 2011, AIME.

[11]  Huilong Duan,et al.  Summarizing clinical pathways from event logs , 2013, J. Biomed. Informatics.

[12]  Michel Dojat,et al.  Scenario recognition for temporal reasoning in medical domains , 1998, Artif. Intell. Medicine.

[13]  Roque Marín,et al.  Temporal similarity measures for querying clinical workflows , 2009, Artif. Intell. Medicine.

[14]  Wei Wang,et al.  Sequential Pattern Mining in Multi-Databases via Multiple Alignment , 2006, Data Mining and Knowledge Discovery.

[15]  Dan Gusfield,et al.  Algorithms on Strings, Trees, and Sequences - Computer Science and Computational Biology , 1997 .

[16]  Mobyen Uddin Ahmed,et al.  Case-Based Reasoning Systems in the Health Sciences: A Survey of Recent Trends and Developments , 2011, IEEE Transactions on Systems, Man, and Cybernetics, Part C (Applications and Reviews).

[17]  Kyoung-Yun Kim,et al.  Systematic causal knowledge acquisition using FCM Constructor for product design decision support , 2011, Expert Syst. Appl..

[18]  Geoffrey J. McLachlan,et al.  An incremental EM-based learning approach for on-line prediction of hospital resource utilization , 2006, Artif. Intell. Medicine.

[19]  Enrico W. Coiera,et al.  Application of Information Technology: Handheld Computer-based Decision Support Reduces Patient Length of Stay and Antibiotic Prescribing in Critical Care , 2005, J. Am. Medical Informatics Assoc..

[20]  Keon-Hyung Lee,et al.  The Association Between Clinical Pathways and Hospital Length of Stay: A Case Study , 2007, Journal of Medical Systems.

[21]  Francisco Herrera,et al.  A Taxonomy and Experimental Study on Prototype Generation for Nearest Neighbor Classification , 2012, IEEE Transactions on Systems, Man, and Cybernetics, Part C (Applications and Reviews).

[22]  Olivier Poch,et al.  A comprehensive comparison of multiple sequence alignment programs , 1999, Nucleic Acids Res..

[23]  Pirjo Moen,et al.  Attribute, Event Sequence, and Event Type Similarity Notions for Data Mining , 2000 .

[24]  Elpida T. Keravnou,et al.  Temporal representation and reasoning in medicine: Research directions and challenges , 2006, Artif. Intell. Medicine.

[25]  Roque Marín,et al.  Temporal similarity by measuring possibilistic uncertainty in CBR , 2009, Fuzzy Sets Syst..

[26]  R K Jain A semi-Markov model for the average length of stay in transient states and its application. , 1989, Computers and biomedical research, an international journal.

[27]  Huilong Duan,et al.  Anomaly detection in clinical processes , 2012, AMIA.

[28]  Huilong Duan,et al.  On mining clinical pathway patterns from medical behaviors , 2012, Artif. Intell. Medicine.

[29]  Stephen Chu,et al.  Improving clinical pathway design: lessons learned from a computerised prototype , 1998, Int. J. Medical Informatics.

[30]  R. M. Chandrasekaran,et al.  Evaluation of k-Nearest Neighbor classifier performance for direct marketing , 2010, Expert Syst. Appl..

[31]  J. Tu,et al.  Use of a neural network as a predictive instrument for length of stay in the intensive care unit following cardiac surgery. , 1993, Computers and biomedical research, an international journal.

[32]  Mary Carol Ramos,et al.  The Successful Utilization of Financial Data in the Support of Care Management , 1999 .

[33]  L. Doering,et al.  Determinants of intensive care unit length of stay after coronary artery bypass graft surgery. , 2001, Heart & lung : the journal of critical care.

[34]  Feng Zhou,et al.  A Case-Driven Ambient Intelligence System for Elderly in-Home Assistance Applications , 2011, IEEE Transactions on Systems, Man, and Cybernetics, Part C (Applications and Reviews).