A comparison of methods for sniff measurement concurrent with olfactory tasks in humans.

There is a growing appreciation for the role of sniffing in the formation of the olfactory percept. With this in mind, monitoring and measurement of sniffing is an important aspect of olfactory experiments. There are several methods for measuring human sniffs concurrent with odor delivery in olfactory experiments. Here, we set out to compare the temporal sensitivity and power of these different methods by applying them all simultaneously with an olfactory task. We discuss the advantages and disadvantages of each method and conclude in recommending the use of a nasal cannula linked to a pressure sensor whenever possible.

[1]  D. G. Laing Characterisation of Human Behaviour during Odour Perception , 1982, Perception.

[2]  E B Kern,et al.  The human nasal cycle. , 1977, Mayo Clinic proceedings.

[3]  Thomas A Cleland,et al.  Anatomical contributions to odorant sampling and representation in rodents: zoning in on sniffing behavior. , 2006, Chemical senses.

[4]  R. Wetzel,et al.  Respiratory inductance plethysmography used to diagnose bilateral diaphragmatic paralysis: A case report , 2004, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[5]  S. Loring,et al.  A simple and reliable method to calibrate respiratory magnetometers and Respitrace. , 1995, Journal of applied physiology.

[6]  J H Auchincloss,et al.  Changes in tidal volume, frequency, and ventilation induced by their measurement. , 1972, Journal of applied physiology.

[7]  Noam Sobel,et al.  Rapid olfactory processing implicates subcortical control of an olfactomotor system. , 2003, Journal of neurophysiology.

[8]  J D Gabrieli,et al.  An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Noam Sobel,et al.  The sniff is part of the olfactory percept. , 2006, Chemical senses.

[10]  D. G. Laing Optimum perception of odor intensity by humans , 1985, Physiology & Behavior.

[11]  D. G. Laing Identification of single dissimilar odors is achieved by humans with a single sniff , 1986, Physiology & Behavior.

[12]  Philippe Litaudon,et al.  Respiratory modulation of olfactory neurons in the rodent brain. , 2006, Chemical senses.

[13]  Gilles Laurent,et al.  Olfactory network dynamics and the coding of multidimensional signals , 2002, Nature Reviews Neuroscience.

[14]  K P Van de Woestijne,et al.  Influence of awareness of the recording of breathing on respiratory pattern in healthy humans. , 1997, The European respiratory journal.

[15]  Richard L. Doty,et al.  An examination of relationships between the pleasantness, intensity, and concentration of 10 odorous stimuli , 1975 .

[16]  J. D. E. Gabrieli,et al.  Sniffing and smelling: separate subsystems in the human olfactory cortex , 1998, Nature.

[17]  Robert Tibshirani,et al.  An Introduction to the Bootstrap , 1994 .

[18]  D. Rodenstein,et al.  Influence of the respiratory route on the resting breathing pattern in humans. , 1985, American Review of Respiratory Disease.

[19]  M A Sackner,et al.  Accuracy of respiratory inductive plethysmographic cross-sectional areas. , 1988, Journal of applied physiology.

[20]  Adam Kepecs,et al.  The sniff as a unit of olfactory processing. , 2006, Chemical senses.

[21]  Vernon A. Benignus,et al.  A computer-controlled vapor-dilution olfactometer , 1980 .

[22]  F D Stott,et al.  Inductive plethysmography--a new respiratory transducer [proceedings]. , 1977, The Journal of physiology.

[23]  Milledge Js,et al.  Inductive plethysmography--a new respiratory transducer [proceedings]. , 1977 .

[24]  L. Tripp,et al.  Phrenic Nerve Injury Following Cardiac Surgery: A Review , 1998, Journal of cardiac surgery.

[25]  J. Magnen Étude des facteurs dynamiques de l'excitation olfactive , 1944 .

[26]  V. C. Allison,et al.  An Investigation of Stenches and Odors for Industrial 'Purposes. , 1919 .

[27]  R. H. Wright,et al.  Sense of Smell , 1982 .

[28]  M J Tobin,et al.  Separation of factors responsible for change in breathing pattern induced by instrumentation. , 1985, Journal of applied physiology.

[29]  R. Reed,et al.  A sense of smell , 1992, Current Biology.

[30]  A. Drake,et al.  Effects of odorants and irritants on respiratory behavior , 1994, The Laryngoscope.

[31]  D. G. Laing,et al.  Natural Sniffing Gives Optimum Odour Perception for Humans , 1983, Perception.

[32]  P. Dalton,et al.  Numerical modeling of turbulent and laminar airflow and odorant transport during sniffing in the human and rat nose. , 2006, Chemical senses.

[33]  F D McCool,et al.  Breathing patterns during varied activities. , 1992, Journal of applied physiology.

[34]  P. Dalton,et al.  Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. , 2004, Chemical senses.

[35]  A. Grinvald,et al.  Spatio-Temporal Dynamics of Odor Representations in the Mammalian Olfactory Bulb , 2002, Neuron.

[36]  D. Tucker,et al.  Physical Variables in the Olfactory Stimulation Process , 1963, The Journal of general physiology.

[37]  M A Sackner,et al.  Accuracy of respiratory inductive plethysmograph over wide range of rib cage and abdominal compartmental contributions to tidal volume in normal subjects and in patients with chronic obstructive pulmonary disease. , 1984, The American review of respiratory disease.

[38]  J. J. Principato,et al.  Cyclical changes in nasal resistance. , 1970, Archives of otolaryngology.

[39]  R. Gesteland,et al.  Assessment of the Sniff Magnitude Test as a clinical test of olfactory function , 2003, Physiology & Behavior.

[40]  M. M. Mozell,et al.  A mass transport model of olfaction. , 1994, Journal of theoretical biology.

[41]  M. Bensafi,et al.  Olfactomotor activity during imagery mimics that during perception , 2003, Nature Neuroscience.

[42]  J C Walker,et al.  Human responses to propionic acid. II. Quantification of breathing responses and their relationship to perception. , 2001, Chemical senses.

[43]  M. M. Mozell,et al.  Numerical simulation of airflow in the human nasal cavity. , 1995, Journal of biomechanical engineering.

[44]  J. Mead,et al.  Measurement of the separate volume changes of rib cage and abdomen during breathing. , 1967, Journal of applied physiology.

[45]  Clinton C. Brown Methods in psychophysiology , 1967 .

[46]  Z. Mainen,et al.  Speed and accuracy of olfactory discrimination in the rat , 2003, Nature Neuroscience.

[47]  David E. Hornung,et al.  A quantitative analysis of sniffing strategies in rats performing odor detection tasks , 1987, Physiology & Behavior.

[48]  Gerd Kobal,et al.  Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation , 1985, Pain.

[49]  M. Sackner,et al.  Validation of respiratory inductive plethysmography using different calibration procedures. , 2015, The American review of respiratory disease.