Magnetic resonance microscopy: recent advances and applications.

Magnetic resonance microscopy is receiving increased attention as more researchers in the biological sciences are turning to non-invasive imaging to characterize development, perturbations, phenotypes and pathologies in model organisms ranging from amphibian embryos to adult rodents and even plants. The limits of spatial resolution are being explored as hardware improvements address the need for increased sensitivity. Recent developments include in vivo cell tracking, restricted diffusion imaging, functional magnetic resonance microscopy and three-dimensional mouse atlases. Important applications are also being developed outside biology in the fields of fluid mechanics, geology and chemistry.

[1]  Alan P. Koretsky,et al.  Tracing Odor-Induced Activation in the Olfactory Bulbs of Mice Using Manganese-Enhanced Magnetic Resonance Imaging , 2002, NeuroImage.

[2]  Brian K Rutt,et al.  Imaging single mammalian cells with a 1.5 T clinical MRI scanner , 2003, Magnetic resonance in medicine.

[3]  R E Jacobs,et al.  Towards a microMRI atlas of mouse development. , 1999, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[4]  Luisa Ciobanu,et al.  Measuring reaction kinetics by using multiple microcoil NMR spectroscopy. , 2003, Angewandte Chemie.

[5]  J. Seymour,et al.  Magnetic resonance microscopy of biofilm structure and impact on transport in a capillary bioreactor. , 2004, Journal of magnetic resonance.

[6]  Susumu Mori,et al.  Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging , 2004, Magnetic resonance in medicine.

[7]  R. Balaban,et al.  Meeting report: NHLBI symposium on phenotyping: mouse cardiovascular function and development. , 2003, Physiological Genomics.

[8]  Jean-Marie Bonny,et al.  Dynamic magnetic resonance microscopy of flour dough fermentation. , 2004, Magnetic resonance imaging.

[9]  Ichio Aoki,et al.  In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI , 2004, NeuroImage.

[10]  R. Jacobs,et al.  In vivo trans‐synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI) , 2003, Magnetic resonance in medicine.

[11]  Jeffrey R Tenney,et al.  fMRI of Brain Activation in a Genetic Rat Model of Absence Seizures , 2004, Epilepsia.

[12]  Reinhold Ludwig,et al.  Corticothalamic Modulation during Absence Seizures in Rats: A Functional MRI Assessment , 2003, Epilepsia.

[13]  Mohammed Shoaib,et al.  Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats , 2004, NeuroImage.

[14]  Sridhar S Kannurpatti,et al.  Effect of anesthesia on CBF, MAP and fMRI-BOLD signal in response to apnea , 2004, Brain Research.

[15]  V. Wedeen,et al.  Diffusion MRI of Complex Neural Architecture , 2003, Neuron.

[16]  Scott E. Fraser,et al.  MRI: volumetric imaging for vital imaging and atlas construction. , 2003, Nature reviews. Molecular cell biology.

[17]  Y. Xia,et al.  Imaging the velocity profiles in tubeless siphon flow by NMR microscopy. , 2003, Journal of magnetic resonance.

[18]  L. Hedlund,et al.  Morphologic phenotyping with MR microscopy: the visible mouse. , 2002, Radiology.

[19]  A. L. Dixon,et al.  Detection of cannabinoid agonist evoked increase in BOLD contrast in rats using functional magnetic resonance imaging , 2004, Neuropharmacology.

[20]  L W Hedlund,et al.  Histology by magnetic resonance microscopy. , 1993, Magnetic resonance quarterly.

[21]  R. Deichmann,et al.  Functional magnetic resonance imaging in intact plants--quantitative observation of flow in plant vessels. , 1998, Magnetic resonance imaging.

[22]  Florence Franconi,et al.  In utero time-course assessment of mouse embryo development using high resolution magnetic resonance imaging , 2002, Anatomy and Embryology.

[23]  V. C. Austin,et al.  Differences in the BOLD fMRI response to direct and indirect cortical stimulation in the rat , 2003, Magnetic resonance in medicine.

[24]  A. Webb,et al.  Signal enhancement by diffusion: experimental observation of the "DESIRE" effect. , 2004, Journal of magnetic resonance.

[25]  W. Köckenberger,et al.  High resolution NMR microscopy of plants and fungi , 2004, Journal of microscopy.

[26]  H. R. Widmer,et al.  Striatal Grafts in a Rat Model of Huntington's Disease: Time Course Comparison of MRI and Histology , 1999, Experimental Neurology.

[27]  H. Merkle,et al.  Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging , 2004, Magnetic resonance in medicine.

[28]  D. Laidlaw,et al.  MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis , 1998, Magnetic resonance in medicine.

[29]  Gaohong Wu,et al.  Opiate tolerance by heroin self‐administration: An fMRI study in rat , 2004, Magnetic resonance in medicine.

[30]  Alan C. Evans,et al.  A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability. , 2005, Cerebral cortex.

[31]  R. Brasch,et al.  Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model , 2001, Journal of magnetic resonance imaging : JMRI.

[32]  A. Pines,et al.  Visualization of gas flow and diffusion in porous media. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[33]  David A Boas,et al.  Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation , 2003, Physics in medicine and biology.

[34]  C. Cheong,et al.  One micrometer resolution NMR microscopy. , 2001, Journal of magnetic resonance.

[35]  F. Volke,et al.  Measuring local flow velocities and biofilm structure in biofilm systems with Magnetic Resonance Imaging (MRI) , 2003, Biotechnology and bioengineering.

[36]  Visualization of transport: NMR microscopy experiments with model objects for porous media with pore sizes down to 50 microm. , 2004, Solid state nuclear magnetic resonance.

[37]  Eric C Frey,et al.  Development of a 4-D digital mouse phantom for molecular imaging research. , 2004, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[38]  D L Buckley,et al.  MR microscopy of multicomponent diffusion in single neurons , 2001, Magnetic resonance in medicine.

[39]  Alan P Koretsky,et al.  MRI detection of single particles for cellular imaging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Hao Huang,et al.  Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging , 2003, NeuroImage.

[41]  H. Pfeifer.  Principles of Nuclear Magnetic Resonance Microscopy , 1992 .

[42]  Marvin D Nelson,et al.  Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. , 2003, Molecular imaging.

[43]  John Russell,et al.  Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water , 2002, NeuroImage.

[44]  Yu-Chung N. Cheng,et al.  Magnetic Resonance Imaging: Physical Principles and Sequence Design , 1999 .

[45]  R. Jacobs,et al.  Three-dimensional digital mouse atlas using high-resolution MRI. , 2001, Developmental biology.

[46]  Sridhar S Kannurpatti,et al.  Baseline physiological state and the fMRI‐BOLD signal response to apnea in anesthetized rats , 2003, NMR in biomedicine.

[47]  T. L. James,et al.  CHAPTER 2 – PRINCIPLES OF NUCLEAR MAGNETIC RESONANCE , 1975 .

[48]  L. Hedlund,et al.  Magnetic resonance histology for morphologic phenotyping , 2002, Journal of magnetic resonance imaging : JMRI.

[49]  Edward W Hsu,et al.  Three‐dimensional diffusion tensor microscopy of fixed mouse hearts , 2004, Magnetic resonance in medicine.

[50]  W. Köckenberger.  Nuclear magnetic resonance micro-imaging in the investigation of plant cell metabolism. , 2001, Journal of experimental botany.

[51]  L. Ciobanu,et al.  3D micron-scale MRI of single biological cells. , 2004, Solid state nuclear magnetic resonance.

[52]  Alan P Koretsky,et al.  Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. , 2003, Blood.

[53]  N. van Bruggen,et al.  Quantification of tumor tissue populations by multispectral analysis , 2004, Magnetic resonance in medicine.

[54]  R Mark Henkelman,et al.  Multiple‐mouse MRI , 2003, Magnetic resonance in medicine.

[55]  Anca Constantinescu,et al.  Comparison of BOLD contrast and Gd‐DTPA dynamic contrast‐enhanced imaging in rat prostate tumor , 2004, Magnetic resonance in medicine.

[56]  Tomoyuki Haishi,et al.  Super‐parallel MR microscope , 2003, Magnetic resonance in medicine.

[57]  F. Howe,et al.  Tumor vascular architecture and function evaluated by non‐invasive susceptibility MRI methods and immunohistochemistry , 2003, Journal of magnetic resonance imaging : JMRI.

[58]  P. Basser,et al.  Diffusion tensor MR imaging of the human brain. , 1996, Radiology.

[59]  B. Shyu,et al.  BOLD response to direct thalamic stimulation reveals a functional connection between the medial thalamus and the anterior cingulate cortex in the rat , 2004, Magnetic resonance in medicine.

[60]  B. Mcewen,et al.  Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment , 2002, Brain Research.