The Statistical Analysis of Interval-Censored Failure Time Data with Applications

The analysis of survival data is a major focus of statistics. Interval censored data reflect uncertainty as to the exact times the units failed within an interval. This type of data frequently comes from tests or situations where the objects of interest are not constantly monitored. Thus events are known only to have occurred between the two observation periods. Interval censoring has become increasingly common in the areas that produce failure time data. This paper explores the statistical analysis of interval-censored failure time data with applications. Three different data sets, namely Breast Cancer, Hemophilia, and AIDS data were used to illustrate the methods during this study. Both parametric and nonparametric methods of analysis are carried out in this study. Theory and methodology of fitted models for the interval-censored data are described. Fitting of parametric and non-parametric models to three real data sets are considered. Results derived from different methods are presented and also compared.

[1]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[2]  David R. Cox,et al.  Regression models and life tables (with discussion , 1972 .

[3]  C. J. Stone,et al.  Logspline Density Estimation for Censored Data , 1992 .

[4]  Rupert G. Miller Least squares regression with censored data , 1976 .

[5]  S W Lagakos,et al.  Analysis of doubly-censored survival data, with application to AIDS. , 1989, Biometrics.

[6]  S G Self,et al.  Linear rank tests for interval-censored data with application to PCB levels in adipose tissue of transformer repair workers. , 1986, Biometrics.

[7]  R B D'Agostino,et al.  Maximum likelihood estimation for interval-censored data using a Weibull-based accelerated failure time model. , 1992, Biometrics.

[8]  Gordon Johnston,et al.  Statistical Models and Methods for Lifetime Data , 2003, Technometrics.

[9]  N Schenker,et al.  Multiple imputation for threshold-crossing data with interval censoring. , 1993, Statistics in medicine.

[10]  C. Geyer,et al.  Maximum likelihood for interval censored data: Consistency and computation , 1994 .

[11]  R. Wolfe,et al.  A semiparametric model for regression analysis of interval-censored failure time data. , 1985, Biometrics.

[12]  D. Collett Modelling survival data , 1994 .

[13]  J C Lindsey,et al.  Tutorial in biostatistics methods for interval-censored data. , 1998, Statistics in medicine.

[14]  L Ryan,et al.  Semiparametric Regression Analysis of Interval‐Censored Data , 2000, Biometrics.

[15]  I. James,et al.  Linear regression with censored data , 1979 .

[16]  Jianguo Sun,et al.  The Statistical Analysis of Interval-censored Failure Time Data , 2006 .

[17]  C. Farrington Interval censored survival data: a generalized linear modelling approach. , 1996, Statistics in medicine.

[18]  G. Rücker,et al.  Remission duration: an example of interval-censored observations. , 1988, Statistics in medicine.

[19]  D. Finkelstein,et al.  A proportional hazards model for interval-censored failure time data. , 1986, Biometrics.

[20]  J. K. Lindsey,et al.  A Study of Interval Censoring in Parametric Regression Models , 1998, Lifetime data analysis.

[21]  B. Turnbull The Empirical Distribution Function with Arbitrarily Grouped, Censored, and Truncated Data , 1976 .

[22]  W. D. Ray 4. Modelling Survival Data in Medical Research , 1995 .

[23]  P. Rosenberg,et al.  Hazard function estimation using B-splines. , 1995, Biometrics.

[24]  R. Peto,et al.  Experimental Survival Curves for Interval‐Censored Data , 1973 .