Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β

TGF-β signals through Smad-dependent and non-Smad pathways, depending on cell context. In ovarian cancer cells, the clathrin adaptor Dab2 enhances internalization of the type I TGF-β receptor, restricts its lateral mobility, and inhibits TGF-β–mediated, cholesterol-dependent JNK activation.

[1]  F. Jänicke,et al.  The prognostic significance of Jun transcription factors in ovarian cancer , 2013, Journal of Cancer Research and Clinical Oncology.

[2]  J. Massagué.  TGFβ signalling in context , 2012, Nature Reviews Molecular Cell Biology.

[3]  P. Fratzl,et al.  SMAD versus Non-SMAD Signaling Is Determined by Lateral Mobility of Bone Morphogenetic Protein (BMP) Receptors* , 2012, The Journal of Biological Chemistry.

[4]  N. Smorodinsky,et al.  Differential Regulation of Smad3 and of the Type II Transforming Growth Factor-β Receptor in Mitosis: Implications for Signaling , 2012, PloS one.

[5]  Melissa J. Davis,et al.  Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions? , 2012, Developmental cell.

[6]  Y. Henis,et al.  Coated Pit-mediated Endocytosis of the Type I Transforming Growth Factor-β (TGF-β) Receptor Depends on a Di-leucine Family Signal and Is Not Required for Signaling* , 2012, The Journal of Biological Chemistry.

[7]  Zhijian J. Chen,et al.  Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition , 2011, Cell.

[8]  Y. Henis,et al.  Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling. , 2011, Cellular signalling.

[9]  C. Meyer,et al.  Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes. , 2011, Journal of hepatology.

[10]  N. Smorodinsky,et al.  Negative Regulation of the Endocytic Adaptor Disabled-2 (Dab2) in Mitosis* , 2010, The Journal of Biological Chemistry.

[11]  P. Howe,et al.  Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2 , 2010, Molecular Biology of the Cell.

[12]  Jonathan A. Cooper,et al.  Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. , 2010, The Journal of clinical investigation.

[13]  Gerard C Blobe,et al.  Roles for the type III TGF-beta receptor in human cancer. , 2010, Cellular signalling.

[14]  Fan Zhang,et al.  Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF-β Pathway Signaling Indicates Response to Primary Chemotherapy , 2010, Clinical Cancer Research.

[15]  M. Carey,et al.  c-Jun-NH2-kinase-1 Inhibition Leads to Antitumor Activity in Ovarian Cancer , 2009, Clinical Cancer Research.

[16]  C. Heldin,et al.  The regulation of TGFβ signal transduction , 2009, Development.

[17]  J. López-Novoa,et al.  The emerging role of TGF-beta superfamily coreceptors in cancer. , 2009, Biochimica et biophysica acta.

[18]  L. Traub.  Tickets to ride: selecting cargo for clathrin-regulated internalization , 2009, Nature Reviews Molecular Cell Biology.

[19]  G. Hsiao,et al.  Inhibitors of clathrin-dependent endocytosis enhance TGFβ signaling and responses , 2009, Journal of Cell Science.

[20]  C. Heldin,et al.  Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. , 2009, Current opinion in cell biology.

[21]  M. Ehrlich,et al.  Dab2 regulates clathrin assembly and cell spreading. , 2009, The Biochemical journal.

[22]  C. Heldin,et al.  The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner , 2008, Nature Cell Biology.

[23]  M. Yamashita,et al.  TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. , 2008, Molecular cell.

[24]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[25]  Gerard C Blobe,et al.  Role of transforming growth factor-beta superfamily signaling pathways in human disease. , 2008, Biochimica et biophysica acta.

[26]  R. Ralhan,et al.  Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancer , 2007, Breast Cancer Research and Treatment.

[27]  Yair Lotan,et al.  Decreased DOC-2/DAB2 Expression in Urothelial Carcinoma of the Bladder , 2007, Clinical Cancer Research.

[28]  Jonathan A. Cooper,et al.  The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH , 2006, Journal of Cell Science.

[29]  Y. Henis,et al.  Clustering of Raft-Associated Proteins in the External Membrane Leaflet Modulates Internal Leaflet H-Ras Diffusion and Signaling , 2006, Molecular and Cellular Biology.

[30]  Simon C Watkins,et al.  A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. , 2006, Molecular biology of the cell.

[31]  Y. Henis,et al.  FRAP beam-size analysis to measure palmitoylation-dependent membrane association dynamics and microdomain partitioning of Ras proteins. , 2006, Methods.

[32]  Y. Henis,et al.  Different Routes of Bone Morphogenic Protein (BMP) Receptor Endocytosis Influence BMP Signaling , 2006, Molecular and Cellular Biology.

[33]  Y. Henis,et al.  Cyclodextrins but not Compactin Inhibit the Lateral Diffusion of Membrane Proteins Independent of Cholesterol , 2006, Traffic.

[34]  Xuedong Liu,et al.  Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling , 2005, Molecular and Cellular Biology.

[35]  P. Howe,et al.  Disabled-2 (Dab2) Mediates Transforming Growth Factor β (TGFβ)-stimulated Fibronectin Synthesis through TGFβ-activated Kinase 1 and Activation of the JNK Pathway* , 2005, Journal of Biological Chemistry.

[36]  Bianca Habermann,et al.  Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis , 2005, Nature.

[37]  P. Howe,et al.  Disabled-2 (Dab2) Is Required for Transforming Growth Factor β-induced Epithelial to Mesenchymal Transition (EMT)* , 2005, Journal of Biological Chemistry.

[38]  Erming Tian,et al.  Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: Identification of candidate molecular markers for ovarian cancer diagnosis and therapy , 2004, International journal of cancer.

[39]  R. Pagano,et al.  Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. , 2004, Molecular biology of the cell.

[40]  J. Bonifacino,et al.  Signals for sorting of transmembrane proteins to endosomes and lysosomes. , 2003, Annual review of biochemistry.

[41]  Hong-Hee Kim,et al.  Lipid rafts are important for the association of RANK and TRAF6 , 2003, Experimental & Molecular Medicine.

[42]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[43]  Jeffrey L. Wrana,et al.  Distinct endocytic pathways regulate TGF-β receptor signalling and turnover , 2003, Nature Cell Biology.

[44]  C. Heldin,et al.  Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses* , 2003, The Journal of Biological Chemistry.

[45]  A. Chawla,et al.  TGFβ receptor internalization into EEA1-enriched early endosomes , 2002, The Journal of Cell Biology.

[46]  J. Doré,et al.  Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway , 2002, Molecular and Cellular Biology.

[47]  Xiang-Xi Xu,et al.  The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway , 2001, The EMBO journal.

[48]  Y. Henis,et al.  A single internalization signal from the di-leucine family is critical for constitutive endocytosis of the type II TGF-beta receptor. , 2001, Journal of cell science.

[49]  M. Bitzer,et al.  Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor* , 2001, The Journal of Biological Chemistry.

[50]  Kai Simons,et al.  Lipid rafts and signal transduction , 2000, Nature Reviews Molecular Cell Biology.

[51]  M. Roth,et al.  Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells , 1998, The Journal of cell biology.

[52]  M. Roth,et al.  Dynamic or Stable Interactions of Influenza Hemagglutinin Mutants with Coated Pits , 1995, The Journal of Biological Chemistry.

[53]  P. Oh,et al.  Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules , 1994, The Journal of cell biology.

[54]  H. Lodish,et al.  The types II and III transforming growth factor-beta receptors form homo-oligomers , 1994, The Journal of cell biology.

[55]  R. G. Anderson,et al.  Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation , 1993, The Journal of cell biology.

[56]  M. Roth,et al.  Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits , 1991, The Journal of cell biology.

[57]  J. Heuser,et al.  Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation , 1989, The Journal of cell biology.

[58]  G K Lewis,et al.  Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product , 1985, Molecular and cellular biology.

[59]  Ye-Guang Chen.  Endocytic regulation of TGF-β signaling , 2009, Cell Research.

[60]  Mary E. Choi,et al.  Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells* , 2009, The Journal of Biological Chemistry.

[61]  Ying E Zhang,et al.  Non-Smad pathways in TGF-β signaling , 2009, Cell Research.

[62]  Sushmita Mukherjee,et al.  Membrane domains. , 2004, Annual review of cell and developmental biology.

[63]  A. Moustakas,et al.  The Types II and III Transforming Growth Factor-Receptors Form Homo-Oligomers , 2002 .

[64]  A. Chawla,et al.  TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. , 2002, The Journal of cell biology.

[65]  Yoav I. Henis,et al.  Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit. , 2002, Molecular biology of the cell.