The relationship between leptin level and oxidative status parameters in hemodialysis patients.

Both serum leptin level and oxidative stress are increased in hemodialysis (HD) patients. In the present study, we aimed to investigate whether there is association between oxidative status and leptin level in HD patients. Thirty-five HD patients and 25 healthy controls were enrolled in the present study. Serum leptin level, total peroxide (TP) level, total antioxidant capacity (TAC), and oxidative stress index (OSI) were determined. Serum leptin level, TP level, and OSI were significantly higher in HD patients than controls (all P < 0.001) while TAC was lower (P < 0.001). In HD patients, serum leptin level was significantly correlated with TP level and OSI (r = 0.372, P < 0.001 and r = 0.409, P < 0.001, respectively). The correlation of serum leptin level with TP level and OSI remained statistically significant after adjusting for age, gender, and body-fat percentage (r = 0.446, P < 0.001 and r = 0.463, P < 0.001, respectively). Hyperleptinemia seems to be associated with increased oxidative stress in HD patients, and this association may provide better understanding about the disorders related to either elevated serum leptin levels and/or increased oxidative stress in HD patients.

[1]  H. Çelik,et al.  Insulin resistance in H pylori infection and its association with oxidative stress. , 2006, World journal of gastroenterology.

[2]  D. Konukoğlu,et al.  Plasma leptin and its relationship with lipid peroxidation and nitric oxide in obese female patients with or without hypertension. , 2006, Archives of medical research.

[3]  J. H. Lee,et al.  Insulin resistance, adipokines, and oxidative stress in nondiabetic, hypercholesterolemic patients: leptin as an 8-epi-prostaglandin F2alpha determinant. , 2006, Metabolism: clinical and experimental.

[4]  H. Sinzinger,et al.  Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy. , 2006, British journal of clinical pharmacology.

[5]  Da‐hong Wang,et al.  Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. , 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  M. Tuzcu,et al.  Exogenous leptin increases lipid peroxidation in the mouse brain. , 2004, The Tohoku journal of experimental medicine.

[7]  P. Gnerre,et al.  Leptin as a uremic toxin interferes with neutrophil chemotaxis. , 2004, Journal of the American Society of Nephrology : JASN.

[8]  A. Localio,et al.  Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. , 2004, The Journal of clinical endocrinology and metabolism.

[9]  J. Chan,et al.  Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis , 2004, Clinical endocrinology.

[10]  Jun Ren,et al.  Leptin and hyperleptinemia - from friend to foe for cardiovascular function. , 2004, The Journal of endocrinology.

[11]  D. Wink,et al.  Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[12]  O. Erel,et al.  A novel automated method to measure total antioxidant response against potent free radical reactions. , 2004, Clinical biochemistry.

[13]  O. Erel,et al.  Increased oxidative stress in patients with hydatidiform mole. , 2003, Swiss medical weekly.

[14]  M. Tepel.  Oxidative stress: does it play a role in the genesis of essential hypertension and hypertension of uraemia? , 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[15]  V. Tesar,et al.  Advanced Glycation End Products in Hemodialyzed Patients with Diabetes Mellitus Correlate with Leptin and Leptin/Body Fat Ratio , 2003, Renal failure.

[16]  C. Fraga,et al.  Enalapril Attenuates Oxidative Stress in Diabetic Rats , 2001, Hypertension.

[17]  J. Galle.  Oxidative stress in chronic renal failure. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[18]  J. Himmelfarb,et al.  Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. , 2000, Kidney international.

[19]  C. Zoccali,et al.  AGEs and carbonyl stress: potential pathogenetic factors of long-term uraemic complications. , 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[20]  T. Miyata,et al.  Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: is there oxidative stress in uremia? , 1998, Kidney international.

[21]  R. Prior,et al.  Comparison of different analytical methods for assessing total antioxidant capacity of human serum. , 1998, Clinical chemistry.

[22]  M M Epperlein,et al.  Nature and biological significance of free radicals generated during bicarbonate hemodialysis. , 1996, Journal of the American Society of Nephrology : JASN.

[23]  J. Friedman.  Leptin, leptin receptors and the control of body weight. , 2009, European journal of medical research.

[24]  F. Lönnqvist,et al.  Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. , 1997, Journal of the American Society of Nephrology : JASN.

[25]  F. Lönnqvist,et al.  Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure. , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[26]  K. Sharma,et al.  Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. , 1997, Kidney international.

[27]  Y. Wada,et al.  Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. , 1997, Kidney international.

[28]  S. Klein,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Increased Plasma Leptin Concentration in End-Stage Renal Disease* , 2022 .

[29]  P. Jungers,et al.  Advanced oxidation protein products as a novel marker of oxidative stress in uremia. , 1996, Kidney international.

[30]  M. Thomas,et al.  Lipoperoxidation in plasma and red blood cells of patients undergoing haemodialysis: vitamins A, E, and iron status. , 1994, Free radical biology & medicine.

[31]  M. Toborek,et al.  Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. , 1992, Metabolism: clinical and experimental.

[32]  M. Kazatchkine,et al.  Establishing the relationship between complement activation and stimulation of phagocyte oxidative metabolism in hemodialyzed patients: a randomized prospective study. , 1991, Nephron.

[33]  T. Miyazawa.  Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay. , 1989, Free radical biology & medicine.

[34]  K. Ingold,et al.  The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. , 1987, Biochimica et biophysica acta.

[35]  A S Jackson,et al.  Generalized equations for predicting body density of women. , 1980, Medicine and science in sports and exercise.