E 2 F 1-Regulated MicroRNAs Impair TGF b-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

Fabio Petrocca,1,5 Rosa Visone,1 Mariadele Rapazzotti Onelli,3 Manisha H. Shah,2 Milena S. Nicoloso,1,4 Ivana de Martino,1 Dimitrios Iliopoulos,1 Emanuela Pilozzi,3 Chang-Gong Liu,1 Massimo Negrini,5 Luigi Cavazzini,5 Stefano Volinia,1,5 Hansjuerg Alder,1 Luigi P. Ruco,2 Gustavo Baldassarre,4 Carlo M. Croce,1,* and Andrea Vecchione1,3 1Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program 2Division of Hematology and Oncology, Comprehensive Cancer Center Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA 3Division of Pathology, II University of Rome ‘‘La Sapienza,’’ Ospedale Santo Andrea, Rome 00189, Italy 4Division of Experimental Oncology 2 CRO-IRCCS, Aviano 33081, Italy 5Telethon Facility-Data Mining for Analysis of DNA Microarrays, Department of Experimental and Diagnostic Medicine and Department of Oncology, University of Ferrara, 44100 Ferrara, Italy *Correspondence: carlo.croce@osumc.edu DOI 10.1016/j.ccr.2008.02.013

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