Expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma: an immunopathological study with clinical correlation

Changes in the histochemical characteristics of the surface epithelial mucins is the hallmark of Barrett's metaplasia. The study investigated the pattern of expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma as possible indicators of increased malignant potential.

[1]  N. Shepherd,et al.  Dysplasia in Barrett's oesophagus , 2000 .

[2]  G. Tytgat,et al.  Impact of endoscopic biopsy surveillance of Barrett’s oesophagus on pathological stage and clinical outcome of Barrett’s carcinoma , 1998, Gut.

[3]  M. Reddish,et al.  Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2 , 1998, Nature Medicine.

[4]  L. Pilarski,et al.  The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. , 1996, Cancer research.

[5]  R. Riddell.  The biopsy diagnosis of gastroesophageal reflux disease, "carditis," and Barrett's esophagus, and sequelae of therapy. , 1996, The American journal of surgical pathology.

[6]  J. Dekker,et al.  Muc2 in ulcerative colitis: a quantitative study. , 1995, Biochemical Society transactions.

[7]  J. Gum.  Human mucin glycoproteins: varied structures predict diverse properties and specific functions. , 1995, Biochemical Society transactions.

[8]  J. Dekker,et al.  Biosynthesis of rat MUC2 in colon and its analogy with human MUC2. , 1995, The Biochemical journal.

[9]  Y. S. Kim,et al.  Expression of MUC2 Gene Product in Mucinous Carcinoma of the Breast: Comparison with Invasive Ductal Carcinoma , 1995 .

[10]  J. Wesseling,et al.  Is episialin/MUC1 involved in breast cancer progression? , 1995, Cancer letters.

[11]  Y. Kim,et al.  Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. , 1994, Gastroenterology.

[12]  Y. Kim,et al.  Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. , 1994, The Journal of biological chemistry.

[13]  R. Dahiya,et al.  Heterogeneity of mucin gene expression in normal and neoplastic tissues. , 1993, Cancer research.

[14]  J. Gum,et al.  Mucin genes and the proteins they encode: structure, diversity, and regulation. , 1992, American journal of respiratory cell and molecular biology.

[15]  G J Strous,et al.  Mucin-type glycoproteins. , 1992, Critical reviews in biochemistry and molecular biology.

[16]  J. Bartley,et al.  Determination of apical membrane polarity in mammary epithelial cell cultures: the role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions. , 1990, Experimental cell research.

[17]  R. Lathe,et al.  A transcribed gene, containing a variable number of tandem repeats, codes for a human epithelial tumor antigen. cDNA cloning, expression of the transfected gene and over-expression in breast cancer tissue. , 1990, European journal of biochemistry.

[18]  L. Sobin,et al.  Histological Typing of Oesophageal and Gastric Tumours , 1990, World Health Organization. International Histological Classification of Tumours.

[19]  Y. Kim,et al.  Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. , 1989, The Journal of biological chemistry.

[20]  Y. Monden,et al.  Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features , 1988, Cancer.

[21]  S. Zotter.  Tissue and tumor distribution of human polymorphic epithelial mucin , 1988 .

[22]  S. Povey,et al.  The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1g21–24 , 1987, Annals of human genetics.

[23]  B. Gazzard,et al.  Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. , 1985, Gut.

[24]  R. Lee.  Mucins in Barrett's esophagus: a histochemical study. , 1984, American journal of clinical pathology.