Quantification of total and free concentrations of R- and S-warfarin in human plasma by ultrafiltration and LC-MS/MS

[1]  H. Aboul‐Enein,et al.  Determination of free and total warfarin concentrations in plasma using UPLC MS/MS and its application to a patient samples. , 2012, Biomedical chromatography : BMC.

[2]  G. Miller,et al.  Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3]  M. Miura,et al.  Simultaneous Determination of Warfarin and 7-Hydroxywarfarin Enantiomers by High-Performance Liquid Chromatography With Ultraviolet Detection , 2011, Therapeutic drug monitoring.

[4]  Z. Zuo,et al.  Simultaneous measurement of S-warfarin, R-warfarin, S-7-hydroxywarfarin and R-7-hydroxywarfarin in human plasma by liquid chromatography-tandem mass spectrometry. , 2010, Journal of pharmaceutical and biomedical analysis.

[5]  Chenrong Huang,et al.  Measurement of free concentrations of highly protein-bound warfarin in plasma by ultra performance liquid chromatography-tandem mass spectrometry and its correlation with the international normalized ratio. , 2008, Clinica chimica acta; international journal of clinical chemistry.

[6]  M. Hayakari,et al.  Simultaneous Determination of Warfarin Enantiomers and Its Metabolite in Human Plasma by Column-Switching High-Performance Liquid Chromatography With Chiral Separation , 2007, Therapeutic drug monitoring.

[7]  M. Margaglione,et al.  A rapid method for the quantification of the enantiomers of Warfarin, Phenprocoumon and Acenocoumarol by two-dimensional-enantioselective liquid chromatography/electrospray tandem mass spectrometry , 2007 .

[8]  A. Yacobi,et al.  Protein binding of warfarin enantiomers in serum of humans and rats , 1977, Journal of Pharmacokinetics and Biopharmaceutics.

[9]  W. Naidong,et al.  Development and validation of a sensitive and robust LC-tandem MS method for the analysis of warfarin enantiomers in human plasma. , 2001, Journal of pharmaceutical and biomedical analysis.

[10]  H. Echizen,et al.  Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes , 1998, Clinical pharmacology and therapeutics.

[11]  H. Echizen,et al.  Determination of unbound warfarin enantiomers in human plasma and 7-hydroxywarfarin in human urine by chiral stationary-phase liquid chromatography with ultraviolet or fluorescence and on-line circular dichroism detection. , 1997, Journal of chromatography. B, Biomedical sciences and applications.