Time-Resolved PIV Technique for High Temporal Resolution Measurement of Mechanical Prosthetic Aortic Valve Fluid Dynamics

Prosthetic heart valves (PHVs) have been used to replace diseased native valves for more than five decades. Among these, mechanical PHVs are the most frequently implanted. Unfortunately, these devices still do not achieve ideal behavior and lead to many complications, many of which are related to fluid mechanics. The fluid dynamics of mechanical PHVs are particularly complex and the fine-scale characteristics of such flows call for very accurate experimental techniques. Adequate temporal resolution can be reached by applying time-resolved PIV, a high-resolution dynamic technique which is able to capture detailed chronological changes in the velocity field. The aim of this experimental study is to investigate the evolution of the flow field in a detailed time domain of a commercial bileaflet PHV in a mock-loop mimicking unsteady conditions, by means of time-resolved 2D Particle Image Velocimetry (PIV). The investigated flow field corresponded to the region immediately downstream of the valve plane. Spatial resolution as in “standard” PIV analysis of prosthetic valve fluid dynamics was used. The combination of a Nd:YLF high-repetition-rate double-cavity laser with a high frame rate CMOS camera allowed a detailed, highly temporally resolved acquisition (up to 10000 fps depending on the resolution) of the flow downstream of the PHV. Features that were observed include the non-homogeneity and unsteadiness of the phenomenon and the presence of large-scale vortices within the field, especially in the wake of the valve leaflets. Furthermore, we observed that highly temporally cycle-resolved analysis allowed the different behaviors exhibited by the bileaflet valve at closure to be captured in different acquired cardiac cycles. By accurately capturing hemodynamically relevant time scales of motion, time-resolved PIV characterization can realistically be expected to help designers in improving PHV performance and in furnishing comprehensive validation with experimental data on fluid dynamics numeric modelling.

[1]  S H Chu,et al.  Turbulence characteristics downstream of bileaflet aortic valve prostheses. , 2000, Journal of biomechanical engineering.

[2]  A. P. Yoganathan,et al.  In vitro velocity measurements down strem from the lonescu-Shiley aortic bioprosthesis in steady and pulsatile flow , 2006, Medical and Biological Engineering and Computing.

[3]  A P Yoganathan,et al.  In vitro fluid dynamic evaluation of the Carbomedics bileaflet heart valve prosthesis in the aortic and mitral positions. , 1994, The Journal of heart valve disease.

[4]  E. Meijering,et al.  A chronology of interpolation: from ancient astronomy to modern signal and image processing , 2002, Proc. IEEE.

[5]  J. D. Schaub,et al.  Development of a flow feedback pulse duplicator system with rhesus monkey arterial input impedance characteristics. , 1999 .

[6]  Lorenzo Scalise,et al.  Cardiac valve prosthesis flow performances measured by 2D and 3D-stereo particle image velocimetry , 2004 .

[7]  Ulrich Steinseifer,et al.  Unsteady flow through a new mechanical heart valve prosthesis analysed by digital particle image velocimetry , 2002 .

[8]  Fotis Sotiropoulos,et al.  Flow in Prosthetic Heart Valves: State-of-the-Art and Future Directions , 2005, Annals of Biomedical Engineering.

[9]  A P Yoganathan,et al.  An in vitro investigation of the retrograde flow fields of two bileaflet mechanical heart valves. , 1996, The Journal of heart valve disease.

[10]  Pascal Verdonck,et al.  PIV Measurements with high Temporal Resolution behind Artificial Heart Valves , 2005 .

[11]  M E Cromheecke,et al.  Retrieval analysis of mechanical heart valves: impact on design and clinical practice. , 1998, Artificial organs.

[12]  Michael Unser,et al.  Image interpolation and resampling , 2000 .

[13]  Umberto Morbiducci,et al.  Laser techniques to study prosthetic heart valves fluid dynamics , 2005 .

[14]  P K Paulsen,et al.  Medtronic Hall versus St. Jude Medical mechanical aortic valve: downstream turbulences with respect to rotation in pigs. , 1998, The Journal of heart valve disease.

[15]  Umberto Morbiducci,et al.  Innovative technologies for the assessment of cardiovascular medical devices: state-of-the-art techniques for artificial heart valve testing , 2004, Expert review of medical devices.

[16]  N. Westerhof,et al.  Pressure and Flow Generated by the Left Ventricle against Different Impedances , 1973, Circulation research.

[17]  L. Brush,et al.  McDonaldʼs Blood Flow in Arteries , 1991 .

[18]  B. Lecordier,et al.  Advanced PIV algorithms with Image Distortion Validation and Comparison using Synthetic Images of Turbulent Flow , 2004 .

[19]  H L Petrie,et al.  Determination of principal reynolds stresses in pulsatile flows after elliptical filtering of discrete velocity measurements. , 1993, Journal of biomechanical engineering.

[20]  N H Hwang,et al.  Human red blood cell hemolysis in a turbulent shear flow: contribution of Reynolds shear stresses. , 1984, Biorheology.

[21]  V. Barbaro,et al.  Laser Doppler Anemometry Study of Bidimensional Flows Downstream of Three 19 mm Bileaflet Valves in the Mitral Position, Under Kinematic Similarity , 2000, Annals of Biomedical Engineering.

[22]  On the stability of iterative PIV image interrogation methods , 2004 .

[23]  Toshinosuke Akutsu,et al.  Time-resolved particle image velocimetry and laser doppler anemometry study of the turbulent flow field of bileaflet mechanical mitral prostheses , 2005, Journal of Artificial Organs.

[24]  A. Fontaine,et al.  Identification of Peak Stresses in Cardiac Prostheses: A Comparison of Two‐Dimensional Versus Three‐Dimensional Principal Stress Analyses , 1996, ASAIO journal.

[25]  E. Meijering.  A chronology of interpolation: from ancient astronomy to modern signal and image processing , 2002, Proc. IEEE.

[26]  L J TEMPLE,et al.  Principles of Fluid Mechanics Applied to Some Situations in the Human Circulation and particularly to the Testing of Valves in a Pulse Duplicator , 1964, Thorax.

[27]  Olga Pierrakos,et al.  Time-resolved DPIV analysis of vortex dynamics in a left ventricular model through bileaflet mechanical and porcine heart valve prostheses. , 2004, Journal of biomechanical engineering.

[28]  Fotis Sotiropoulos,et al.  Numerical simulation of flow in mechanical heart valves: grid resolution and the assumption of flow symmetry. , 2003, Journal of biomechanical engineering.

[29]  M Grigioni,et al.  A discussion on the threshold limit for hemolysis related to Reynolds shear stress. , 1999, Journal of biomechanics.

[30]  Markus Raffel,et al.  Particle Image Velocimetry: A Practical Guide , 2002 .

[31]  T Dohi,et al.  Effect of the sinus of valsalva on the closing motion of bileaflet prosthetic heart valves. , 2000, Artificial organs.

[32]  S C Koenig,et al.  Development of a flow feedback pulse duplicator system with rhesus monkey arterial input impedance characteristics. , 1999, ASAIO journal.

[33]  Umberto Morbiducci,et al.  Three-Dimensional Numeric Simulation of Flow Through an Aortic Bileaflet Valve in a Realistic Model of Aortic Root , 2005, ASAIO journal.

[34]  B. Bellhouse,et al.  Fluid Mechanics of the Aortic Root with Application to Coronary Flow , 1968, Nature.

[35]  M. Wernet.  Symmetric phase only filtering: a new paradigm for DPIV data processing , 2005 .

[36]  S. Deutsch,et al.  Integrating particle image velocimetry and laser Doppler velocimetry measurements of the regurgitant flow field past mechanical heart valves. , 2001, Artificial organs.

[37]  Lorenzo Scalise,et al.  3D PIV Measurements of prosthetic heart valves fluid dynamics , 2005 .

[38]  M Marangolo.  High dose Chemotherapy and Hematopoietic Progenitor cell Reinfusion in the Treatment of Solid Tumors , 1999, The International journal of artificial organs.

[39]  Ajit P. Yoganathan,et al.  Experimental Investigation of the Steady Flow Downstream of the St. Jude Bileaflet Heart Valve: A Comparison Between Laser Doppler Velocimetry and Particle Image Velocimetry Techniques , 2004, Annals of Biomedical Engineering.

[40]  Gino Gerosa,et al.  Leaflet Escape in a New Bileaflet Mechanical Valve: TRI Technologies , 2003, Circulation.

[41]  R. Adrian,et al.  Effect of resolution on the speed and accuracy of particle image velocimetry interrogation , 1992 .

[42]  H Harasaki,et al.  Particle image velocimetry investigation of intravalvular flow fields of a bileaflet mechanical heart valve in a pulsatile flow. , 2000, The Journal of heart valve disease.

[43]  Hwa Liang Leo,et al.  Fluid Dynamic Assessment of Three Polymeric Heart Valves Using Particle Image Velocimetry , 2006, Annals of Biomedical Engineering.

[44]  M Grigioni,et al.  19 mm Sized Bileaflet Valve Prostheses’ flow Field Investigated by Bidimensional Laser Doppler Anemometry (part I: Velocity Profiles) , 1997, The International journal of artificial organs.

[45]  H T Low,et al.  Pulsatile flow studies of a porcine bioprosthetic aortic valve in vitro: PIV measurements and shear-induced blood damage. , 2001, Journal of biomechanics.

[46]  R. Adrian.  Particle-Imaging Techniques for Experimental Fluid Mechanics , 1991 .

[47]  P K Paulsen,et al.  Estimation of turbulent shear stresses in pulsatile flow immediately downstream of two artificial aortic valves in vitro. , 1990, Journal of biomechanics.

[48]  J. R. Carl,et al.  The Bjork-Shiley Aortic Prosthesis Flow Characteristics, Thrombus Formation and Tissue Overgrowth , 1978, Circulation.

[49]  Steven Deutsch,et al.  Regurgitant flow field characteristics of the St. Jude bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry. , 2003, Artificial organs.

[50]  Alberto Redaelli,et al.  3-D simulation of the SJM bileaflet valve opening process: fluid-structure interaction study and experimental validation , 2004 .

[51]  H. Reul,et al.  Estimation of Shear Stress-related Blood Damage in Heart Valve Prostheses - in Vitro Comparison of 25 Aortic Valves , 1990, The International journal of artificial organs.

[52]  Patrick Segers,et al.  Predicting ATS Open Pivot heart valve performance with computational fluid dynamics. , 2005, The Journal of heart valve disease.

[53]  F. Scarano.  Iterative image deformation methods in PIV , 2002 .