Spatial coding of enantiomers in the rat olfactory bulb

Because of their unique properties, enantiomers (pairs of mirror-symmetric, nonsuperimposable molecules that differ only in optical activity and their interaction with other chiral molecules) have been instrumental in demonstrating that olfactory perception relies on molecular shape. To investigate how molecular structure is encoded by the olfactory system, we combined behavioral discrimination tasks with optical imaging of intrinsic signals. We found that rats can behaviorally discriminate members of a wide range of enantiomer pairs, and imaging revealed enantiomer-selective glomeruli in the olfactory bulb, indicating that the spatial pattern of glomerular activity provides sufficient information to discriminate molecular shape.

[1]  Naoshige Uchida,et al.  Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features , 2000, Nature Neuroscience.

[2]  L. C. Katz,et al.  Optical Imaging of Odorant Representations in the Mammalian Olfactory Bulb , 1999, Neuron.

[3]  S. Shafran,et al.  A B C d e f g ... , 1996, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

[4]  Gilles Laurent,et al.  Olfactory processing: maps, time and codes , 1997, Current Opinion in Neurobiology.

[5]  P. Mombaerts,et al.  Molecular biology of odorant receptors in vertebrates. , 1999, Annual review of neuroscience.

[6]  B. Trask,et al.  Distribution of olfactory receptor genes in the human genome , 1998, Nature Genetics.

[7]  Michael Leon,et al.  Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb , 1998 .

[8]  G. Shepherd,et al.  Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. , 1997, Annual review of neuroscience.

[9]  M. Laska,et al.  Olfactory discrimination ability of human subjects for ten pairs of enantiomers. , 1999, Chemical senses.

[10]  G. Shepherd,et al.  Functional organization of rat olfactory bulb analysed by the 2‐deoxyglucose method , 1979, The Journal of comparative neurology.

[11]  R. Friedrich,et al.  Combinatorial and Chemotopic Odorant Coding in the Zebrafish Olfactory Bulb Visualized by Optical Imaging , 1997, Neuron.

[12]  G M Shepherd,et al.  Functional mosaic organization of mouse olfactory receptor neurons. , 2000, Proceedings of the National Academy of Sciences of the United States of America.