Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

[1]  P. Libby,et al.  Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.

[2]  Tanya M. Teslovich,et al.  Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease , 2017, The New England journal of medicine.

[3]  Richard G. Lee,et al.  Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides , 2017, The New England journal of medicine.

[4]  E. Biessen,et al.  HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? , 2017, Expert review of cardiovascular therapy.

[5]  A. Keech,et al.  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease , 2017, The New England journal of medicine.

[6]  Xenia Geeraerts,et al.  Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity , 2017, Front. Immunol..

[7]  A. Chawla,et al.  Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  C. Tsatsanis,et al.  Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization , 2017, The Journal of Immunology.

[9]  Kimberly R. McDaniels,et al.  High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. , 2017, Cell metabolism.

[10]  J. Nilsson,et al.  oxLDL antibody inhibits MCP‐1 release in monocytes/macrophages by regulating Ca2+/K+ channel flow , 2016, Journal of cellular and molecular medicine.

[11]  C. Glass,et al.  Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. , 2016, Immunity.

[12]  L. Beckers,et al.  Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes , 2016, Thrombosis and Haemostasis.

[13]  D. Tavian,et al.  Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity. , 2016, Genetics and Molecular Research.

[14]  B. Trigatti,et al.  Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth , 2016, Journal of the American Heart Association.

[15]  B. Okopień,et al.  Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling , 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

[16]  Jian-zhi Zhou,et al.  Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation , 2016, International journal of molecular sciences.

[17]  Jens-Peter Volkmer,et al.  CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis , 2016, Nature.

[18]  P. Quax,et al.  Heat‐killed Staphylococcus aureus reduces atherosclerosis by inducing anti‐inflammatory macrophages , 2016, Journal of internal medicine.

[19]  A. Tall,et al.  Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming , 2016, Science Translational Medicine.

[20]  K. Sunagawa,et al.  Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE −/− Mice , 2016, Arteriosclerosis, thrombosis, and vascular biology.

[21]  Werner Müller,et al.  Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice. , 2016, Atherosclerosis.

[22]  Yang Li,et al.  Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis. , 2016, Genetics and molecular research : GMR.

[23]  Matthias Gieseke,et al.  Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects , 2015, International journal of molecular sciences.

[24]  D. Ramji,et al.  Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets , 2015, Cytokine & growth factor reviews.

[25]  P. Loke,et al.  MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. , 2015, The Journal of clinical investigation.

[26]  R. McPherson,et al.  IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis. , 2015, Circulation research.

[27]  S. Kato,et al.  Receptor-selective IL-4 mutein modulates inflammatory vascular cell phenotypes and attenuates atherogenesis in apolipoprotein E-knockout mice. , 2015, Experimental and molecular pathology.

[28]  K. Ley,et al.  Monocyte trafficking across the vessel wall. , 2015, Cardiovascular research.

[29]  T. Mohana,et al.  Inhibition of differentiation of monocyte to macrophages in atherosclerosis by oligomeric proanthocyanidins -In-vivo and in-vitro study. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[30]  P. Tsai,et al.  Phosphoinositide 3-kinase β, phosphoinositide 3-kinase δ, and phosphoinositide 3-kinase γ mediate the anti-inflammatory effects of magnesium sulfate. , 2015, The Journal of surgical research.

[31]  L. Boon,et al.  CD8+ T Cells Regulate Monopoiesis and Circulating Ly6C-high Monocyte Levels in Atherosclerosis in Mice. , 2015, Circulation research.

[32]  Laura S. Shankman,et al.  Correction: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis , 2015, Nature Medicine.

[33]  P. Tipping,et al.  Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes. , 2015, Cardiovascular research.

[34]  Laura S. Shankman,et al.  KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis , 2015, Nature Medicine.

[35]  Z. Fayad,et al.  Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation , 2015, Science Advances.

[36]  C. Gleissner,et al.  CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7+S100A8+ in vitro and in vivo , 2015, Innate immunity.

[37]  J. Kuiper,et al.  Oxidized Low-Density Lipoprotein–Induced Apoptotic Dendritic Cells as a Novel Therapy for Atherosclerosis , 2015, The Journal of Immunology.

[38]  K. Moore,et al.  Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[39]  L. Goedeke,et al.  Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  A. Tedgui,et al.  Angiotensin II Mobilizes Spleen Monocytes to Promote the Development of Abdominal Aortic Aneurysm in Apoe−/− Mice , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[41]  P. Tsai,et al.  Anti-inflammation effects of naloxone involve phosphoinositide 3-kinase delta and gamma. , 2014, The Journal of surgical research.

[42]  W. Boisvert,et al.  Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function , 2014, Thrombosis and Haemostasis.

[43]  K. Vickers,et al.  Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice , 2014, Journal of Lipid Research.

[44]  博章 加藤.  ATP Binding Cassetteトランスポーターの構造薬理学 , 2014 .

[45]  H. Chung,et al.  Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. , 2014, Cellular signalling.

[46]  R. Feil,et al.  Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis , 2014, Circulation research.

[47]  K. Fujiwara,et al.  ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis , 2014, Circulation.

[48]  A. Tall,et al.  Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[49]  S. Allahverdian,et al.  Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis , 2014, Circulation.

[50]  Joshua M. Akey,et al.  Resurrecting Surviving Neandertal Lineages from Modern Human Genomes , 2014, Science.

[51]  L. Beckers,et al.  Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[52]  B. Ley,et al.  A Systematic Review and Meta-Analysis of the Performance of Two Point of Care Typhoid Fever Tests, Tubex TF and Typhidot, in Endemic Countries , 2013, PloS one.

[53]  E. Latz,et al.  High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3 , 2013, Nature Immunology.

[54]  A. Wagenaar,et al.  Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model , 2013, PloS one.

[55]  A. Tall,et al.  Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children. , 2013, Atherosclerosis.

[56]  P. Libby,et al.  Local proliferation dominates lesional macrophage accumulation in atherosclerosis , 2013, Nature Medicine.

[57]  Christine E. Becker,et al.  CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation , 2013, Nature Immunology.

[58]  P. Cohen,et al.  IL-17 Stimulates Differentiation of Human Anti-Inflammatory Macrophages and Phagocytosis of Apoptotic Neutrophils in Response to IL-10 and Glucocorticoids , 2013, The Journal of Immunology.

[59]  A. Tall,et al.  Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. , 2013, Cell metabolism.

[60]  S. Desiderio,et al.  Stat3β mitigates development of atherosclerosis in apolipoprotein E-deficient mice , 2013, Journal of Molecular Medicine.

[61]  A. Tall,et al.  Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice , 2013, Circulation research.

[62]  B. Cronstein,et al.  The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling , 2013, Inflammation.

[63]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[64]  M. Daemen,et al.  Distribution of macrophage polarization markers in human atherosclerosis. , 2012, Atherosclerosis.

[65]  K. Węglarczyk,et al.  Chemokine receptors and chemokine production by CD34+ stem cell-derived monocytes in response to cancer cells. , 2012, Anticancer research.

[66]  B. Cremers,et al.  CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography. , 2012, Journal of the American College of Cardiology.

[67]  O. Wagner,et al.  Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype , 2012, EMBO molecular medicine.

[68]  James R. Springstead,et al.  Role of Phospholipid Oxidation Products in Atherosclerosis , 2012, Circulation research.

[69]  K. Wood,et al.  Inflammatory Ly-6Chi monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients , 2012, Atherosclerosis.

[70]  E. Podrez,et al.  Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. , 2012, Cell metabolism.

[71]  Philip N. Tsichlis,et al.  Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization , 2012, Proceedings of the National Academy of Sciences.

[72]  Charles P. Lin,et al.  Myocardial infarction accelerates atherosclerosis , 2012, Nature.

[73]  J. Pollard,et al.  A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells , 2012, Science.

[74]  Alberto Mantovani,et al.  Orchestration of metabolism by macrophages. , 2012, Cell metabolism.

[75]  K. Ley,et al.  NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis , 2012, Circulation research.

[76]  B. Hedblad,et al.  Elevated CD14++CD16− Monocytes Predict Cardiovascular Events , 2012, Circulation. Cardiovascular genetics.

[77]  P. Libby,et al.  Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions , 2012, Circulation.

[78]  R. Virmani,et al.  Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. , 2012, Journal of the American College of Cardiology.

[79]  L. Game,et al.  Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection , 2012, Circulation research.

[80]  N. Leitinger,et al.  Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2. , 2011, Free radical biology & medicine.

[81]  T. Wynn,et al.  Protective and pathogenic functions of macrophage subsets , 2011, Nature Reviews Immunology.

[82]  K. Clément,et al.  CD14dimCD16+ and CD14+CD16+ Monocytes in Obesity and During Weight Loss: Relationships With Fat Mass and Subclinical Atherosclerosis , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[83]  Björn Rotter,et al.  SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. , 2011, Blood.

[84]  M. D. de Winther,et al.  Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation , 2011, Thrombosis and Haemostasis.

[85]  Wing-Cheong Wong,et al.  Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. , 2011, Blood.

[86]  S. Strand,et al.  Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor. , 2011, Blood.

[87]  R. Beelen,et al.  Macrophages in skin injury and repair. , 2011, Immunobiology.

[88]  P. Libby,et al.  Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo , 2011, Thrombosis and Haemostasis.

[89]  D. Rader,et al.  Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. , 2011, The Journal of clinical investigation.

[90]  G. Ligresti,et al.  Macrophage-Derived Tumor Necrosis Factor-&agr; Is an Early Component of the Molecular Cascade Leading to Angiogenesis in Response to Aortic Injury , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[91]  Mohamed Amine Bouhlel,et al.  Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPAR&ggr; and LXR&agr; Pathways , 2011, Circulation research.

[92]  G. Hansson,et al.  The immune system in atherosclerosis , 2011, Nature Immunology.

[93]  R. Weissleder,et al.  Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction , 2010, Circulation research.

[94]  J. Orange,et al.  Correction of Wiskott-Aldrich Syndrome by Hematopoietic Stem Cell Gene Therapy , 2010 .

[95]  J. Mehta,et al.  AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol. , 2010, Atherosclerosis.

[96]  Silvano Sozzani,et al.  Nomenclature of monocytes and dendritic cells in blood. , 2010, Blood.

[97]  T. Akasaka,et al.  Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris. , 2010, Atherosclerosis.

[98]  J. Casanova,et al.  Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors , 2010, Immunity.

[99]  Michael R. Elliott,et al.  Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2 , 2010, Circulation research.

[100]  Hiroto Tsujioka,et al.  Association of monocyte subsets with vulnerability characteristics of coronary plaques as assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris. , 2010, Atherosclerosis.

[101]  Egil Lien,et al.  NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals , 2010, Nature.

[102]  A. Tall,et al.  ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation , 2010, Science.

[103]  David M. Mosser,et al.  Exploring the full spectrum of macrophage activation , 2010, Nature Reviews Immunology.

[104]  C. Binder.  Natural IgM Antibodies Against Oxidation-Specific Epitopes , 2010, Journal of Clinical Immunology.

[105]  P. Libby,et al.  Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. , 2010, Journal of the American College of Cardiology.

[106]  R. Koenen,et al.  Therapeutic targeting of chemokine interactions in atherosclerosis , 2010, Nature Reviews Drug Discovery.

[107]  C. Gleissner,et al.  CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages , 2010, Circulation research.

[108]  K. Moore,et al.  CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer , 2009, Nature Immunology.

[109]  G. Natoli,et al.  Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB , 2009, Proceedings of the National Academy of Sciences.

[110]  D. Iliopoulos,et al.  The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. , 2009, Immunity.

[111]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[112]  B. Pence,et al.  Exercise training‐induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti‐inflammatory influence of exercise? , 2008, Journal of leukocyte biology.

[113]  I. van der Made,et al.  P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice. , 2008, Cardiovascular research.

[114]  D. Schrijvers,et al.  Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe−/− Mice , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[115]  P. Serruys,et al.  Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque 'shoulder'. , 2008, European heart journal.

[116]  S. Yusuf,et al.  Telmisartan, ramipril, or both in patients at high risk for vascular events. , 2008, The New England journal of medicine.

[117]  T. Simon,et al.  Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice , 2008, Circulation.

[118]  R. Virmani,et al.  Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo , 2008, Circulation.

[119]  M. Zembala,et al.  Peripheral Blood CD14high CD16+ Monocytes are Main Producers of IL‐10 , 2008, Scandinavian journal of immunology.

[120]  P. Shah,et al.  Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice. , 2007, Journal of the American College of Cardiology.

[121]  M. Birnbaum,et al.  Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. , 2007, Cell metabolism.

[122]  J. F. Schindler,et al.  p38 Pathway Kinases as Anti-inflammatory Drug Targets , 2007, Journal of dental research.

[123]  A. Cumano,et al.  Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior , 2007, Science.

[124]  E. Tuzcu,et al.  -Blockers and Progression of Coronary Atherosclerosis: Pooled Analysis of 4 Intravascular Ultrasonography Trials , 2007, Annals of Internal Medicine.

[125]  G. Stark,et al.  Signal Transducer and Activator of Transcription 1 Is Required for Optimal Foam Cell Formation and Atherosclerotic Lesion Development , 2007, Circulation.

[126]  N. Reiner,et al.  Monocyte p110α phosphatidylinositol 3‐kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production , 2007 .

[127]  Nichola Figg,et al.  Monocyte/Macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques , 2007, Circulation research.

[128]  P. Libby,et al.  Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. , 2007, The Journal of clinical investigation.

[129]  F. Tacke,et al.  Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. , 2007, The Journal of clinical investigation.

[130]  R. Hammer,et al.  Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. , 2006, The Journal of clinical investigation.

[131]  P. Libby,et al.  Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease , 2006, Proceedings of the National Academy of Sciences.

[132]  A. Tedgui,et al.  Cytokines in atherosclerosis: pathogenic and regulatory pathways. , 2006, Physiological reviews.

[133]  E. Pamer,et al.  Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 , 2006, Nature Immunology.

[134]  P. Ridker,et al.  Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms , 2005, Nature Reviews Drug Discovery.

[135]  C. Cannon,et al.  The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes. , 2005, Journal of the American College of Cardiology.

[136]  Beatriz León,et al.  Monocyte-derived dendritic cells. , 2005, Seminars in immunology.

[137]  V. de Waard,et al.  Repopulation of Apolipoprotein E Knockout Mice With CCR2-Deficient Bone Marrow Progenitor Cells Does Not Inhibit Ongoing Atherosclerotic Lesion Development , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[138]  Silvano Sozzani,et al.  The chemokine system in diverse forms of macrophage activation and polarization. , 2004, Trends in immunology.

[139]  François Mach,et al.  Inflammation and Atherosclerosis , 2004, Herz.

[140]  A. Tedgui,et al.  Leukocyte-Derived Interleukin 10 Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[141]  P. Murray,et al.  Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1 , 2004, The Journal of Immunology.

[142]  S. Blankenberg,et al.  CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-α levels , 2004, Thrombosis and Haemostasis.

[143]  M. Karin,et al.  The two NF-κB activation pathways and their role in innate and adaptive immunity , 2004 .

[144]  N. Cheshire,et al.  Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[145]  N. Van Rooijen,et al.  Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1 , 2004, The Journal of Immunology.

[146]  Matthijs Kramer,et al.  Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[147]  K. Moore,et al.  Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways , 2004, Nature Medicine.

[148]  D. Haskard,et al.  Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery , 2004, Circulation research.

[149]  E. Fisher,et al.  Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[150]  Georg Kraal,et al.  Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. , 2003, The Journal of clinical investigation.

[151]  F. Luscinskas,et al.  Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes , 2003, The Journal of experimental medicine.

[152]  J. Witztum,et al.  Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL , 2003, Nature Medicine.

[153]  D. Mosser,et al.  The many faces of macrophage activation , 2003, Journal of leukocyte biology.

[154]  Peter J. Murray,et al.  Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-101 , 2002, The Journal of Immunology.

[155]  T. Willson,et al.  Synthetic LXR ligand inhibits the development of atherosclerosis in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[156]  G. Hansson,et al.  Expression of Toll-Like Receptors in Human Atherosclerotic Lesions: A Possible Pathway for Plaque Activation , 2002, Circulation.

[157]  Ash A. Alizadeh,et al.  Stereotyped and specific gene expression programs in human innate immune responses to bacteria , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[158]  T. Lawrence,et al.  Possible new role for NF-κB in the resolution of inflammation , 2001, Nature Medicine.

[159]  R. Homer,et al.  Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1 , 2001, The Journal of experimental medicine.

[160]  V. Álvarez,et al.  Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction , 2001, Genes and Immunity.

[161]  Kristi Kincaid,et al.  M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.

[162]  S. Hazen,et al.  Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. , 2000, The Journal of clinical investigation.

[163]  Barry Lewis,et al.  Coronary heart disease: reducing the risk: the scientific background to primary and secondary prevention of coronary heart disease. A worldwide view. International Task force for the Prevention of Coronary Heart disease. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[164]  G. Schmitz,et al.  A more mature phenotype of blood mononuclear phagocytes is induced by fluvastatin treatment in hypercholesterolemic patients with coronary heart disease. , 1999, Atherosclerosis.

[165]  R. Ross,et al.  Atherosclerosis is an Inflammatory Disease , 1998 .

[166]  N. Reiner,et al.  Phosphatidylinositol 3-Kinase Is Involved in the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein* , 1998, The Journal of Biological Chemistry.

[167]  E. Andreeva,et al.  Subendothelial smooth muscle cells of human aorta express macrophage antigen in situ and in vitro. , 1997, Atherosclerosis.

[168]  Yukiko Kurihara,et al.  A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection , 1997, Nature.

[169]  G. Schmitz,et al.  Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[170]  R. Ogilvie,et al.  Basic fibroblast growth factor increases collateral blood flow in rats with femoral arterial ligation. , 1996, Circulation research.

[171]  M. Rekhter,et al.  Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques. , 1995, The American journal of pathology.

[172]  J. Darnell,et al.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.

[173]  B. Passlick,et al.  The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages , 1993, European journal of immunology.

[174]  A. Bradley,et al.  Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. , 1993, Science.

[175]  A. Endo,et al.  The discovery and development of HMG-CoA reductase inhibitors. , 1992, Journal of lipid research.

[176]  R. Ross,et al.  Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits. , 1990, Arteriosclerosis.

[177]  B. Passlick,et al.  Identification and characterization of a novel monocyte subpopulation in human peripheral blood. , 1989, Blood.

[178]  R. van Furth,et al.  THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES , 1968, The Journal of experimental medicine.

[179]  M. Virolainen.  HEMATOPOIETIC ORIGIN OF MACROPHAGES AS STUDIED BY CHROMOSOME MARKERS IN MICE , 1968, The Journal of experimental medicine.

[180]  D. Fliser,et al.  Immunosuppression and monocyte subsets. , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[181]  R. McPherson,et al.  IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis , 2015 .

[182]  P. Libby,et al.  Chigh Monocytes Depend on Nr 4 a 1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium , 2014 .

[183]  S. Verbruggen,et al.  Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo , 2013, Angiogenesis.

[184]  A. Rehemtulla,et al.  Molecular Imaging , 2009, Methods in Molecular Biology.

[185]  C. Peterson,et al.  Adipose tissue macrophages in insulin resistant subjects are 1 associated with collagen VI, fibrosis and demonstrate 2 alternative activation , 2010 .

[186]  Dianqing Wu,et al.  Immunopathology and Infectious Diseases Suppression of PLC 2 by Endotoxin Plays a Role in the Adenosine A 2 A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype , 2010 .

[187]  S. Parthasarathy,et al.  Oxidized low-density lipoprotein. , 2010, Methods in molecular biology.

[188]  J. Marin-Neto.  Telmisartan, ramipril, or both in patients at high risk for vascular events , 2008 .

[189]  M. Daemen,et al.  Atherosclerosis in Mice Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated , 2007 .

[190]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[191]  K. Rajewsky,et al.  Inhibition of NF-κ B activation in macrophages increases atherosclerosis in LDL receptor – deficient mice , 2003 .

[192]  T. Lawrence,et al.  Possible new role for NF-kappaB in the resolution of inflammation. , 2001, Nature medicine.

[193]  J. Hamilton,et al.  Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[194]  B. Passlick,et al.  The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients. , 1993, Blood.

[195]  D. Fliser,et al.  CD14 CD16 Monocytes Independently Predict Cardiovascular Events , 2012 .