Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

[1]  S. Prusiner,et al.  Transmissible and genetic prion diseases share a common pathway of neurodegeneration , 1999, Nature.

[2]  C. Masters,et al.  The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures , 1999, The Journal of Neuroscience.

[3]  K. Yoshikawa,et al.  Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein , 1999, Journal of Neuroscience.

[4]  A. Yang,et al.  Intracellular Accumulation of Insoluble, Newly Synthesized Aβn-42 in Amyloid Precursor Protein-transfected Cells That Have Been Treated with Aβ1–42* , 1999, The Journal of Biological Chemistry.

[5]  L. Mucke,et al.  Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Shioi,et al.  Overexpression in Neurons of Human Presenilin-1 or a Presenilin-1 Familial Alzheimer Disease Mutant Does Not Enhance Apoptosis , 1998, The Journal of Neuroscience.

[7]  T. Russo,et al.  Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor protein , 1998, FEBS letters.

[8]  C. Masters,et al.  Survival of Cultured Neurons from Amyloid Precursor Protein Knock-Out Mice against Alzheimer’s Amyloid-β Toxicity and Oxidative Stress , 1998, The Journal of Neuroscience.

[9]  Bruce A. Yankner,et al.  Aging renders the brain vulnerable to amyloid β-protein neurotoxicity , 1998, Nature Medicine.

[10]  H. Okamura,et al.  Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer , 1998, The Journal of Neuroscience.

[11]  B. Greenberg,et al.  Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester , 1998, The Journal of Neuroscience.

[12]  Hui Zheng,et al.  The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity , 1997, The Journal of Neuroscience.

[13]  D. Selkoe,et al.  Alzheimer's Disease--Genotypes, Phenotype, and Treatments , 1997, Science.

[14]  M. Staufenbiel,et al.  Amyloid precursor protein truncated at any of the γ‐secretase sites is not cleaved to β‐amyloid , 1996 .

[15]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[16]  G. Schellenberg,et al.  Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.

[17]  S. Takeda,et al.  G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP , 1996, Science.

[18]  B. Yankner Mechanisms of Neuronal Degeneration in Alzheimer's Disease , 1996, Neuron.

[19]  Bernhard Schmidt,et al.  Role of microglia and host prion protein in neurotoxicity of a prion protein fragment , 1996, Nature.

[20]  C. Cotman,et al.  Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells , 1995 .

[21]  G. Dawson,et al.  β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity , 1995, Cell.

[22]  B. Yankner,et al.  β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding , 1995, Neuron.

[23]  R. Wetzel,et al.  Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[24]  B. Yankner,et al.  Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[25]  W. Klein,et al.  Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. , 1994, The Journal of biological chemistry.

[26]  C. Behl,et al.  Hydrogen peroxide mediates amyloid β protein toxicity , 1994, Cell.

[27]  S. Younkin,et al.  An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.

[28]  Bruce A. Yankner,et al.  Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus , 1994, Nature.

[29]  M. Mattson,et al.  A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[30]  C. Behl,et al.  The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix , 1993, Brain Research.

[31]  P. May,et al.  Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity , 1993, Journal of neurochemistry.

[32]  R. Neve,et al.  beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. Mattson,et al.  Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF , 1993, Brain Research.

[34]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[35]  Carl W. Cotman,et al.  Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[36]  M. Mattson,et al.  Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein , 1993, Neuron.

[37]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[38]  K. Yoshikawa,et al.  Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor , 1992, Nature.

[39]  Bruce A. Yankner,et al.  Methodological variables in the assessment of beta amyloid neurotoxicity , 1992, Neurobiology of Aging.

[40]  C. Masters,et al.  The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth , 1992, Neuron.

[41]  B. Ledermann,et al.  Establishment of a germ-line competent C57BL/6 embryonic stem cell line. , 1991, Experimental cell research.

[42]  Carl W. Cotman,et al.  In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity , 1991, Brain Research.

[43]  B. Yankner,et al.  An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types , 1991, Neuroscience Letters.

[44]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[45]  B. Anderton,et al.  Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion , 1991, Journal of neuroscience research.

[46]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[47]  G. Cole,et al.  The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion , 1989, Neuron.

[48]  T. Oltersdorf,et al.  Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts , 1989, Cell.

[49]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[50]  R. Dipolo,et al.  Partial purification and characterization of the (Ca2+ + Mg2+)-ATPase from squid optic nerve plasma membrane. , 1984, Biochimica et biophysica acta.

[51]  D. Selkoe Alzheimer's disease: genotypes, phenotypes, and treatments. , 1997, Science.

[52]  C. Cotman,et al.  Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. , 1995, Journal of neurochemistry.

[53]  K. Grzeschik,et al.  The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor , 1987 .