Friend or foe: role of pathological tau in neuronal death.

[1]  H. Du,et al.  Molecularly defined and functionally distinct cholinergic subnetworks , 2022, Neuron.

[2]  Ch Lai,et al.  Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala , 2022, Molecular Psychiatry.

[3]  M. Yamada,et al.  Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine , 2022, The Journal of experimental medicine.

[4]  D. Holtzman,et al.  Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model , 2022, Science Translational Medicine.

[5]  Chen Zhang,et al.  VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription , 2022, Science China Life Sciences.

[6]  Hongwei Sun,et al.  Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition , 2022, Molecular Neurobiology.

[7]  Lingpeng Zhu,et al.  Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis , 2022, Frontiers in Aging Neuroscience.

[8]  Hongyan Zhang,et al.  Sevoflurane Aggravates the Progress of Alzheimer’s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway , 2022, Frontiers in Cell and Developmental Biology.

[9]  Guy C. Brown.  Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons , 2021, International journal of molecular sciences.

[10]  Jie Chen,et al.  Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity , 2021, The Journal of biological chemistry.

[11]  Sung-Chun Tang,et al.  Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke , 2021, Molecular Neurobiology.

[12]  Ling-Qiang Zhu,et al.  Ferroptosis, a Potential Therapeutic Target in Alzheimer’s Disease , 2021, Frontiers in Cell and Developmental Biology.

[13]  B. Kuster,et al.  Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion , 2021, Nature Communications.

[14]  S. Haggarty,et al.  ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids , 2021, Cell.

[15]  Lu Wang,et al.  Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction , 2021, Metabolic Brain Disease.

[16]  R. Reynolds,et al.  TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus , 2021, Acta Neuropathologica Communications.

[17]  T. Pufe,et al.  Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells , 2021, Cells.

[18]  Nicholas E. Propson,et al.  Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading , 2021, Proceedings of the National Academy of Sciences.

[19]  B. Hyman,et al.  Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice , 2021, Nature Communications.

[20]  B. Ghetti,et al.  Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates , 2021, bioRxiv.

[21]  Guy C. Brown,et al.  Microglial phagocytosis of neurons in neurodegeneration, and its regulation , 2021, Journal of neurochemistry.

[22]  E. Baulieu,et al.  Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress , 2021, Autophagy.

[23]  P. Nelson,et al.  Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease , 2021, Cell Death & Differentiation.

[24]  S. Chinnathambi,et al.  α– Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia , 2021, Cell adhesion & migration.

[25]  W. Chen,et al.  Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis , 2020, Brain Research.

[26]  T. Arzberger,et al.  The relation between tau pathology and granulovacuolar degeneration of neurons , 2020, Neurobiology of Disease.

[27]  A. Kao,et al.  Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation , 2021, Frontiers in Neurology.

[28]  Qiu-Yan Wu,et al.  Inhibitory Effects of Isobavachalcone on Tau Protein Aggregation, Tau Phosphorylation, and Oligomeric Tau-Induced Apoptosis. , 2020, ACS chemical neuroscience.

[29]  Christoph N Schlaffner,et al.  Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease , 2020, Cell.

[30]  A. Goate,et al.  Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics , 2020, Trends in Neurosciences.

[31]  R. Morkūnienė,et al.  Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures , 2020, Molecular Neurobiology.

[32]  N. Zhang,et al.  Heme Induces BECN1/ATG5-Mediated Autophagic Cell Death via ER Stress in Neurons , 2020, Neurotoxicity Research.

[33]  E. Konofagou,et al.  Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy , 2020, Science Advances.

[34]  Shyh-Hsiang Lin,et al.  1,25(OH)2D3 Alleviates Aβ(25-35)-Induced Tau Hyperphosphorylation, Excessive Reactive Oxygen Species, and Apoptosis Through Interplay with Glial Cell Line-Derived Neurotrophic Factor Signaling in SH-SY5Y Cells , 2020, International journal of molecular sciences.

[35]  Jilong Shen,et al.  Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis. , 2020, Acta tropica.

[36]  Hye Kyong Kweon,et al.  Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death , 2020, Molecular Neurobiology.

[37]  D. Klenerman,et al.  Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase , 2020, The FEBS journal.

[38]  R. Jahn,et al.  Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia , 2020, bioRxiv.

[39]  S. Pinton,et al.  Tau affects P53 function and cell fate during the DNA damage response , 2020, Communications Biology.

[40]  L. Bodea,et al.  PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy , 2020, Acta Neuropathologica.

[41]  Ji Yeon Song,et al.  Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy , 2020, Progress in Neurobiology.

[42]  Yu Luo,et al.  MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration , 2020, Autophagy.

[43]  J. Ros,et al.  Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. , 2019, Cell calcium.

[44]  V. Borutaite,et al.  Extracellular tau induces microglial phagocytosis of living neurons in cell cultures , 2019, Journal of neurochemistry.

[45]  B. de Strooper,et al.  Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease , 2019, Acta Neuropathologica.

[46]  L. Goldstein,et al.  Amyloid-β-independent regulators of tau pathology in Alzheimer disease , 2019, Nature Reviews Neuroscience.

[47]  P. Liu,et al.  Interaction between hyperphosphorylated tau and pyroptosis in forskolin and streptozotocin induced AD models. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[48]  L. Buée,et al.  NLRP3 inflammasome activation drives tau pathology , 2019, Nature.

[49]  W. Scheper,et al.  Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology , 2019, Acta Neuropathologica.

[50]  Melanie A. Huntley,et al.  Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. , 2019, Cell reports.

[51]  Y. Guan,et al.  Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling , 2019, Front. Neurol..

[52]  G. van Loo,et al.  Inflammasomes in neuroinflammatory and neurodegenerative diseases , 2019, EMBO molecular medicine.

[53]  G. Johnson,et al.  BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes , 2019, bioRxiv.

[54]  T. Manivasagam,et al.  Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats , 2019, Neurotoxicity Research.

[55]  I. Dewachter,et al.  Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo , 2019, Acta Neuropathologica.

[56]  Nicholas E. Propson,et al.  Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease , 2018, Neuron.

[57]  Melanie A. Huntley,et al.  Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies , 2018, Neuron.

[58]  Junying Yuan,et al.  Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases , 2018, Nature Reviews Neuroscience.

[59]  C. Soares-Cunha,et al.  Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology , 2018, Cell Death & Differentiation.

[60]  M. Heneka,et al.  Inflammasome signalling in brain function and neurodegenerative disease , 2018, Nature Reviews Neuroscience.

[61]  B. Ghetti,et al.  Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia , 2018, Cell reports.

[62]  Zhoumeng Lin,et al.  CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. , 2018, Toxicology letters.

[63]  Wenyan Sun,et al.  Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies , 2018, Nature Neuroscience.

[64]  Hans-Ulrich Klein,et al.  Tau Activates Transposable Elements in Alzheimer’s Disease , 2018, Cell reports.

[65]  A. Tolkovsky,et al.  Neuronal Cell Death. , 2018, Physiological reviews.

[66]  Zhan-You Wang,et al.  α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice , 2017, Redox biology.

[67]  M. Ankarcrona,et al.  Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences , 2017, Neuroscience Letters.

[68]  S. Lipton,et al.  Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 , 2018, Cell Death & Differentiation.

[69]  A. Bush,et al.  Tau-mediated iron export prevents ferroptotic damage after ischemic stroke , 2017, Molecular Psychiatry.

[70]  Winnie S. Liang,et al.  Necroptosis activation in Alzheimer's disease , 2017, Nature Neuroscience.

[71]  Peter Vandenabeele,et al.  Initiation and execution mechanisms of necroptosis: an overview , 2017, Cell Death and Differentiation.

[72]  Scott J. Dixon,et al.  Ferroptosis: bug or feature? , 2017, Immunological reviews.

[73]  D. Green,et al.  Caspase‐8: regulating life and death , 2017, Immunological reviews.

[74]  Wendy Noble,et al.  Roles of tau protein in health and disease , 2017, Acta Neuropathologica.

[75]  C. Pantelis,et al.  Lithium suppression of tau induces brain iron accumulation and neurodegeneration , 2017, Molecular Psychiatry.

[76]  Y. Li,et al.  MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells , 2017, Oncotarget.

[77]  A. Ittner.  SITE-SPECIFIC PHOSPHORYLATION OF TAU INHIBITS AMYLOID-β TOXICITY IN ALZHEIMER’S MICE , 2016, Alzheimer's & Dementia.

[78]  Jung-Mi Hah,et al.  Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice , 2016, EMBO molecular medicine.

[79]  T. Manivasagam,et al.  Tannoid principles of Emblica officinalis attenuated aluminum chloride induced apoptosis by suppressing oxidative stress and tau pathology via Akt/GSK-3βsignaling pathway. , 2016, Journal of ethnopharmacology.

[80]  C. Duyckaerts,et al.  Caspase-cleaved Tau-D421 is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons , 2016, Neurobiology of Aging.

[81]  Jorge Tolivia,et al.  Regional and Gender Study of Neuronal Density in Brain during Aging and in Alzheimer's Disease , 2016, Front. Aging Neurosci..

[82]  Junying Yuan,et al.  RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS , 2016, Science.

[83]  Dacheng Wang,et al.  Pore-forming activity and structural autoinhibition of the gasdermin family , 2016, Nature.

[84]  Xing-jian Lin,et al.  Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation , 2016, Neural regeneration research.

[85]  F. Holsboer,et al.  FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications , 2016, Molecular Psychiatry.

[86]  E. Mandelkow,et al.  Tau in physiology and pathology , 2015, Nature Reviews Neuroscience.

[87]  T. Cai,et al.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.

[88]  A. Bush,et al.  Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse , 2015, Neurobiology of Disease.

[89]  C. Richter-Landsberg,et al.  Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes , 2015, Glia.

[90]  C. Masters,et al.  Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau , 2015, Neurotherapeutics.

[91]  Long Yang,et al.  Necrostatin-1 protection of dopaminergic neurons , 2015, Neural regeneration research.

[92]  Shan Wang,et al.  A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau , 2015, Cerebral cortex.

[93]  M. Frotscher,et al.  Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation , 2015, Acta neuropathologica communications.

[94]  Masayuki Miura,et al.  Programmed cell death in neurodevelopment. , 2015, Developmental cell.

[95]  H. Gertz,et al.  Early neurone loss in Alzheimer’s disease: cortical or subcortical? , 2015, Acta neuropathologica communications.

[96]  B. Levine,et al.  Autosis and autophagic cell death: the dark side of autophagy , 2014, Cell Death and Differentiation.

[97]  Jian-Zhi Wang,et al.  Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation , 2014, Journal of neurochemistry.

[98]  John L. Robinson,et al.  TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord , 2014, Acta Neuropathologica.

[99]  Guy C. Brown,et al.  Microglial phagocytosis of live neurons , 2014, Nature Reviews Neuroscience.

[100]  Mackenzie W. Mathis,et al.  Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS , 2014, Neuron.

[101]  D. Holtzman,et al.  Neuronal activity regulates extracellular tau in vivo , 2014, The Journal of experimental medicine.

[102]  W. Noble,et al.  A role for tau at the synapse in Alzheimer's disease pathogenesis , 2014, Neuropharmacology.

[103]  N. Chattipakorn,et al.  Combined Therapy of Iron Chelator and Antioxidant Completely Restores Brain Dysfunction Induced by Iron Toxicity , 2014, PloS one.

[104]  J. Götz,et al.  Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus , 2013, PloS one.

[105]  M. Deshmukh,et al.  Mature neurons: equipped for survival , 2013, Cell Death and Disease.

[106]  S. Lovestone,et al.  The Importance of Tau Phosphorylation for Neurodegenerative Diseases , 2013, Front. Neurol..

[107]  Ewout J. N. Groen,et al.  Protein aggregation in amyotrophic lateral sclerosis , 2013, Acta Neuropathologica.

[108]  L. Staudt,et al.  Control of autophagic cell death by caspase-10 in multiple myeloma. , 2013, Cancer cell.

[109]  G. Bloom,et al.  Amyloid-&bgr; signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease , 2013, Journal of Cell Science.

[110]  Wendy Noble,et al.  Physiological release of endogenous tau is stimulated by neuronal activity , 2013, EMBO reports.

[111]  Pu Wang,et al.  Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain , 2013, Neurochemistry International.

[112]  B. Crain,et al.  Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[113]  R. Nixon,et al.  Autophagy and neuronal cell death in neurological disorders. , 2012, Cold Spring Harbor perspectives in biology.

[114]  Tao Wang,et al.  Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake , 2012, Neurochemistry International.

[115]  Qian-Qian Jiang,et al.  Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response , 2012, Apoptosis.

[116]  T. Cai,et al.  The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury , 2012, International journal of biological sciences.

[117]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[118]  T. Gao,et al.  Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia , 2012, CNS neuroscience & therapeutics.

[119]  Blaine R. Roberts,et al.  Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export , 2012, Nature Medicine.

[120]  G. Pell,et al.  Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study. , 2012 .

[121]  R A Knight,et al.  Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 , 2011, Cell Death and Differentiation.

[122]  Masaaki Komatsu,et al.  Autophagy: Renovation of Cells and Tissues , 2011, Cell.

[123]  F. Terro,et al.  Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β , 2011, Neurochemistry International.

[124]  Meaghan Morris,et al.  The Many Faces of Tau , 2011, Neuron.

[125]  Y. Zhang,et al.  Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease , 2011, Cell Death and Disease.

[126]  K. Ashe,et al.  Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.

[127]  Jürgen Götz,et al.  Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.

[128]  H. Nishina,et al.  Involvement of JNK in the regulation of autophagic cell death , 2010, Oncogene.

[129]  B. Hyman,et al.  Caspase activation precedes and leads to tangles , 2010, Nature.

[130]  Eric H. Baehrecke,et al.  Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila , 2009, Current Biology.

[131]  David Park,et al.  Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy , 2009, PloS one.

[132]  G. Kroemer,et al.  Autophagic cell death: the story of a misnomer , 2008, Nature Reviews Molecular Cell Biology.

[133]  A. Gorman,et al.  Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling , 2008, Journal of cellular and molecular medicine.

[134]  F. Terro,et al.  Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection , 2008, Neuroscience Letters.

[135]  P. Tacnet-Delorme,et al.  C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition1 , 2008, The Journal of Immunology.

[136]  M. Koike,et al.  Autophagic neuron death in neonatal brain ischemia/hypoxia , 2008, Autophagy.

[137]  E. Baehrecke,et al.  Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila , 2007, Cell.

[138]  M. Elstner,et al.  Individual dopaminergic neurons show raised iron levels in Parkinson disease , 2007, Neurology.

[139]  Huaxi Xu,et al.  Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration , 2007, Proceedings of the National Academy of Sciences.

[140]  Dale E. Bredesen,et al.  Cell death in the nervous system , 2006, Nature.

[141]  Sudeshna Dutta,et al.  Autophagic programmed cell death by selective catalase degradation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[142]  M. Costanzi,et al.  NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[143]  W. Janssen,et al.  Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte , 2005, Cell.

[144]  Alexei Degterev,et al.  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury , 2005, Nature chemical biology.

[145]  Craig B. Thompson,et al.  Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes , 2004, Nature Cell Biology.

[146]  Ajjai Alva,et al.  Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8 , 2004, Science.

[147]  J. Schulz,et al.  Neuronal pathology in Parkinson’s disease , 2004, Cell and Tissue Research.

[148]  J. Morrison,et al.  Progressive degeneration of nonphosphorylated neurofilament protein‐enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9 , 2003, The Journal of comparative neurology.

[149]  Claudio Soto,et al.  Unfolding the role of protein misfolding in neurodegenerative diseases , 2003, Nature Reviews Neuroscience.

[150]  Hironobu Naiki,et al.  Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease , 2002 .

[151]  Junying Yuan,et al.  Apoptosis in the nervous system , 2000, Nature.

[152]  Ronald C. Petersen,et al.  Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.

[153]  G. Perry,et al.  Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[154]  Richard Hollister,et al.  Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease , 1997, Annals of neurology.

[155]  Khadija Iqbal,et al.  Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[156]  R. A. Crowther,et al.  Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease , 1989, Neuron.

[157]  R. Crowther,et al.  Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. , 1989, The EMBO journal.

[158]  J. Walker,et al.  Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[159]  M. Kirschner,et al.  Tau protein function in living cells , 1986, The Journal of cell biology.

[160]  A. Wyllie,et al.  Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics , 1972, British Journal of Cancer.

[161]  R. Lockshin,et al.  Programmed cell death—II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths , 1964 .

[162]  J. Beard.  IV. On the early development of Lepidosteus osseus. — Preliminary notice , 1890, Proceedings of the Royal Society of London.