Immunocytochemical analysis of receptors for estrogen and progesterone in fine‐needle aspirates from human breast carcinomas

Monoclonal antibodies were used for a preoperative analysis of estrogen receptors (ERs) and progesterone receptors (PgRs) in fine‐needle aspirates from 44 primary human breast carcinomas. The semiquantitative receptor values obtained in cytologic specimens correlated well with those from enzyme immunoassay analysis on surgically removed tumor tissue (r = 0.74 for PgR;r = 0.75 for ER). Cytologic smears showed a heterogenous tumor cell distribution of ER and PgR in 29 and 23 cases, respectively. The results suggest that measurement of the ER and PgR in cytologic smears is an accurate and reliable technique that can be performed on a minimum amount of tissue.

[1]  K. Geisinger,et al.  Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: A marker of hormone response , 1987, Breast Cancer Research and Treatment.

[2]  L. Skoog,et al.  Estrogen receptors in fine-needle aspirates from metastatic lesions of gynecologic tumors. , 1989, Gynecologic oncology.

[3]  T. Powles,et al.  PREDICTION OF ENDOCRINE RESPONSE IN BREAST CANCER BY IMMUNOCYTOCHEMICAL DETECTION OF OESTROGEN RECEPTOR IN FINE-NEEDLE ASPIRATES , 1987, The Lancet.

[4]  L. Skoog,et al.  Immunohistochemical analysis of estrogen receptors in cells obtained by fine needle aspiration from human mammary carcinomas. , 1986, Anticancer research.

[5]  K. Geisinger,et al.  Use of Monoclonal Antiestrogen Receptor Antibody to Evaluate Estrogen Receptor Content in Fine Needle Aspiration Breast Biopsies , 1986, Annals of surgery.

[6]  E B Cox,et al.  Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. , 1985, Archives of pathology & laboratory medicine.

[7]  J. Wittliff Steroid‐hormone receptors in breast cancer , 1984, Cancer.

[8]  G. Greene,et al.  Monoclonal antibodies as probes for estrogen receptor detection and characterization. , 1982, Journal of steroid biochemistry.

[9]  Jensen Ev Steroid receptors in breast cancer: historical perspective. , 1980 .

[10]  D. Byar,et al.  Relationship between estrogen receptor values and clinical data in predicting the response to endocrine therapy for patients with advanced breast cancer. , 1979, European journal of cancer.

[11]  K. Burton [105] Determination of DNA concentration with diphenylamine , 1968 .

[12]  J. Zajicek,et al.  Aspiration biopsy in diagnosis of palpable lesions of the breast. Critical review of 3479 consecutive biopsies. , 1968, Acta radiologica: therapy, physics, biology.