Unsuspected risk factors of frequent exacerbations requiring hospital admission in chronic obstructive pulmonary disease

Severe exacerbations are the leading cause of fatal events in chronic obstructive pulmonary disease (COPD). The new Global Initiative for Chronic Obstructive Lung Disease strategy included the number of exacerbations in the grading of the disease. The primary aim of this study was to evaluate the potentially modifiable precipitating factors of frequent severe exacerbations requiring hospital admission in COPD. The secondary aim was to investigate the risk factors of readmission within 2 months following an exacerbation requiring hospitalisation.

[1]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[2]  F. Martinez,et al.  Exacerbations of chronic obstructive pulmonary disease. , 2007, Proceedings of the American Thoracic Society.

[3]  T. Similowski,et al.  The potential impact of anaemia of chronic disease in COPD , 2006, European Respiratory Journal.

[4]  B. Celli,et al.  Exacerbations of chronic obstructive pulmonary disease , 2007, European Respiratory Journal.

[5]  S. Frøland,et al.  Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. , 1999, Journal of the American College of Cardiology.

[6]  J. Doyle,et al.  Anemia in chronic obstructive pulmonary disease: epidemiology and economic implications. , 2008, Current medical research and opinion.

[7]  A. Anzueto,et al.  Impact of statins and ACE inhibitors on mortality after COPD exacerbations , 2009, Respiratory research.

[8]  J. Wedzicha,et al.  Susceptibility to exacerbation in chronic obstructive pulmonary disease. , 2010, The New England journal of medicine.

[9]  K. Ohta,et al.  Adherence to treatment by patients with asthma or COPD: comparison between inhaled drugs and transdermal patch. , 2007, Respiratory medicine.

[10]  J A Anderson,et al.  Adherence to inhaled therapy, mortality and hospital admission in COPD , 2009, Thorax.

[11]  N. Nahman,et al.  Role of gastroesophageal reflux symptoms in exacerbations of COPD. , 2006, Chest.

[12]  M. Pearson,et al.  Clinical audit indicators of outcome following admission to hospital with acute exacerbation of chronic obstructive pulmonary disease , 2002, Thorax.

[13]  T. Seemungal,et al.  COPD exacerbations: defining their cause and prevention , 2007, The Lancet.

[14]  I. Stanopoulos,et al.  Anemia of Chronic Disease in Chronic Obstructive Pulmonary Disease: A Case-Control Study of Cardiopulmonary Exercise Responses , 2011, Respiration.

[15]  E. Silverman,et al.  Clinical determinants of exacerbations in severe, early-onset COPD , 2007, European Respiratory Journal.

[16]  T. Seemungal,et al.  Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease , 2002, Thorax.

[17]  Nicolas Roche,et al.  Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. , 2009, Chest.

[18]  G. Donaldson,et al.  COPD exacerbations · 1: Epidemiology , 2006, Thorax.

[19]  M. Etminan,et al.  Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. , 2006, Journal of the American College of Cardiology.

[20]  M. Cazzola,et al.  Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: A pilot study. , 2010, Pulmonary pharmacology & therapeutics.

[21]  P. Paggiaro,et al.  Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease , 1998, The Lancet.

[22]  M. Miravitlles.  Review: Do we need new antibiotics for treating exacerbations of COPD? , 2007, Therapeutic advances in respiratory disease.

[23]  T. Seemungal,et al.  Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. , 2000, American journal of respiratory and critical care medicine.

[24]  J E Cotes,et al.  Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. , 1993, The European respiratory journal. Supplement.

[25]  L. Goodnough,et al.  Anemia of chronic disease. , 2005, The New England journal of medicine.

[26]  Thomas Similowski,et al.  Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy. , 2005, Chest.

[27]  J. Soriano,et al.  Prognosis of COPD patients requiring frequent hospitalization: role of airway infection. , 2010, Respiratory medicine.

[28]  T. Seemungal,et al.  Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. , 1998, American journal of respiratory and critical care medicine.

[29]  B. Celli,et al.  Predictors of Survival in COPD: more than just the FEV1. , 2008, Respiratory medicine.

[30]  O. Keene,et al.  Temporal clustering of exacerbations in chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[31]  R. Levy,et al.  Risk factors and outcomes associated with chronic obstructive pulmonary disease exacerbations requiring hospitalization. , 2009, Canadian respiratory journal.

[32]  E. Björnsson,et al.  Prevalence of gastrointestinal symptoms in patients with chronic obstructive pulmonary disease , 2008, European journal of gastroenterology & hepatology.

[33]  K. Kostikas,et al.  Hemoglobin, erythropoietin and systemic inflammation in exacerbations of chronic obstructive pulmonary disease. , 2011, European journal of internal medicine.

[34]  K. Savik,et al.  High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD. , 2007, Chest.