Pulsed CO/sub 2/ laser ablation of tissue: effect of mechanical properties

The ablation rate of guinea pig skin and bovine aorta, myocardium, and liver by a CO/sub 2/ laser emitting 2- mu s-long pulses was quantified. Ablation efficiency was found to be strongly dependent on the ultimate tensile strength of the tissue; the ablation efficiency of liver is seven times that of skin. Gluteraldehyde cross linking of skin, which is known to greatly increase tissue stiffness but not significantly affect ultimate tensile strength, did not change the ablation rate. The water content of the tissues, which largely determines the optical and thermal properties, was measured and found to vary only slightly. The results demonstrate that tissue mechanical properties are important in the interpretation and modeling of pulsed laser ablation of tissue and that variations in these mechanical properties can lead to drastically different cutting rates for different tissues.<<ETX>>

[1]  D R Boughner,et al.  The glutaraldehyde-stabilized porcine aortic valve xenograft. II. Effect of fixation with or without pressure on the tensile viscoelastic properties of the leaflet material. , 1984, Journal of Biomedical Materials Research.

[2]  R. Anderson,et al.  Effect of pulse duration on selective ablation of atherosclerotic plaque by 480‐ to 490‐nanometer laser radiation , 1988, Lasers in surgery and medicine.

[3]  R. D. Harkness,et al.  Effect of Enzymes on Mechanical Properties of Tissues , 1959, Nature.

[4]  R. Kloner,et al.  Effect of myocyte necrosis on strength, strain, and stiffness of isolated myocardial strips. , 1987, American heart journal.

[5]  R. F. Bonner,et al.  Quantification Of Tissue Effects Due To A Pulsed Er:Yag Laser At 2.9 μm With Beam Delivery In A Wet Field Via Zirconium Fluoride Fibers , 1987, Other Conferences.

[6]  J. Koo.  Laser‐induced explosion of solid material , 1977 .

[7]  R M Cothren,et al.  A model for thermal ablation of biological tissue using laser radiation , 1987, Lasers in surgery and medicine.

[8]  T K Borg,et al.  The collagen matrix of the heart. , 1981, Federation proceedings.

[9]  R. Minns,et al.  The effect of calcium on the mechanical behaviour of aorta media elastin and collagen. , 1977, British journal of experimental pathology.

[10]  S. Fine,et al.  The rupture force and tensile strength of canine aortic tissue. , 1972, The Journal of surgical research.

[11]  C. Puliafito,et al.  Excimer laser ablation of the lens. , 1986, Archives of ophthalmology.

[12]  H. Oxlund.  Changes in the biomechanical properties of skin and aorta induced by corticotrophin treatment. , 1980, Acta endocrinologica.

[13]  T E Cooper,et al.  Correlation of thermal properties of some human tissue with water content. , 1971, Aerospace medicine.

[14]  T. Keyes,et al.  Theory of photoablation and its implications for laser phototherapy , 1985 .

[15]  W. Coulson.  The effect of proteolytic enzymes on the tensile strength of whole aorta and isolated aortic elastin. , 1971, Biochimica et biophysica acta.

[16]  H. Oxlund,et al.  The roles of hyaluronic acid, collagen and elastin in the mechanical properties of connective tissues. , 1980, Journal of anatomy.

[17]  R. Srinivasan,et al.  Dynamics of UV laser ablation of organic polymer surfaces , 1986 .

[18]  R. Haut,et al.  Mechanical properties of the canine aorta following hypercholesterolemia. , 1980, Journal of Biomechanical Engineering.

[19]  J. Walsh,et al.  Pulsed CO2 laser tissue ablation: Measurement of the ablation rate , 1988, Lasers in surgery and medicine.

[20]  R. Srinivasan,et al.  Microscopic model for the ablative photodecomposition of polymers by far‐ultraviolet radiation (193 nm) , 1984 .

[21]  R R Krueger,et al.  High-speed photography of excimer laser ablation of the cornea. , 1987, Archives of ophthalmology.

[22]  H. Oxlund.  Relationships between the biomechanical properties, composition and molecular structure of connective tissues. , 1986, Connective tissue research.

[23]  N. Broom,et al.  The stress/strain and fatigue behaviour of glutaraldehyde preserved heart-valve tissue. , 1977, Journal of biomechanics.

[24]  C. Cater,et al.  The reaction of glutaraldehyde with proteins and other biological materials , 1966 .

[25]  J. Ready.  Effects Due to Absorption of Laser Radiation , 1965 .

[26]  Joseph Tonry Walsh.  Pulsed laser ablation of tissue : analysis of the removal process and tissue healing , 1988 .

[27]  H. F. Bowman,et al.  Theory, measurement, and application of thermal properties of biomaterials. , 1975, Annual review of biophysics and bioengineering.

[28]  P. Purslow,et al.  Positional variations in fracture toughness, stiffness and strength of descending thoracic pig aorta. , 1983, Journal of biomechanics.

[29]  S. Factor,et al.  Skeletal framework of mammalian heart muscle. Arrangement of inter- and pericellular connective tissue structures. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[30]  U C Paek,et al.  Observation of Laser-induced Explosion of Solid Materials and Correlation with Theory. , 1974, Applied optics.

[31]  U. Paek,et al.  High-intensity laser-induced vaporization and explosion of solid material , 1971 .

[32]  R. Srinivasan,et al.  Ablation of polymers and biological tissue by ultraviolet lasers. , 1986, Science.

[33]  Cooper Te,et al.  Correlation of thermal properties of some human tissue with water content. , 1971 .

[34]  R G Geronemus,et al.  Ultraviolet laser ablation of skin: Healing studies and a thermal model , 1987, Lasers in surgery and medicine.

[35]  H. Oxlund,et al.  Changes in mechanical properties, thermal stability, reducible cross-links and glycosyl-lysines in rat skin induced by corticosteroid treatment. , 1982, Acta endocrinologica.

[36]  R. D. Harkness,et al.  The collagen and elastin content of the arterial wall in the dog , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[37]  H. Vogel.  Collagen and mechanical strength in various organs of rats treated with D-penicillamine or amino-acetonitrile. , 1975, Connective tissue research.

[38]  R. Anderson,et al.  Selective ablation of atheromas using a flashlamp-excited dye laser at 465 nm. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[39]  P E Dyer,et al.  Far‐ultraviolet laser ablation of the cornea: Photoacoustic studies , 1987, Lasers in surgery and medicine.

[40]  S. Fine,et al.  Effects of sterilization and preservation on the rupture force and tensile strength of canine aortic tissue. , 1973, The Journal of surgical research.

[41]  H. Weber,et al.  Mechanical and thermal parameters in pulsed laser cutting of tissue , 1987 .

[42]  Robert J. Harrach.  Analytical solutions for laser heating and burnthrough of opaque solid slabs , 1977 .

[43]  D R Boughner,et al.  The glutaraldehyde-stabilized porcine aortic valve xenograft. I. Tensile viscoelastic properties of the fresh leaflet material. , 1984, Journal of biomedical materials research.

[44]  G. M. Hale,et al.  Optical Constants of Water in the 200-nm to 200-microm Wavelength Region. , 1973, Applied optics.

[45]  H. Vogel.  Correlation between tensile strength and collagen content in rat skin. Effect of age and cortisol treatment. , 1974, Connective tissue research.

[46]  B. A. Jensen,et al.  Effect of D-penicillamine on the mechanical properties of aorta, muscle tendon and skin in rats. , 1984, Atherosclerosis.