MRI predictors of cognitive outcome in early multiple sclerosis

Cognitive z scores change (y7-baseline) MR parameters included in models R: Univariate analyses p Values: Univariate analyses Adjusted R2 model p Values: Multivariate analyses Memory domainb Baseline EDSSc 0.095 0.54 0.144 0.05 Baseline LLd 0.333 0.05 Baseline BPF 0.126 0.42 Baseline VF 0.175 0.26 Baseline mean lesion MTRd 0.253 0.10 Baseline mean NABT MTRc 0.377 0.05 Baseline EDSSc 0.095 0.54 0.009 0.54 LL change over 2 y 0.085 0.59 BPF change over 2 yd 0.200 0.19 VF change over 2 yd 0.290 0.05 Mean lesion MTR change over 2 y 0.090 0.57 Mean NABT MTR change over 2 y 0.057 0.72 IPS domaine Baseline EDSSc 0.273 0.07 0.416 0.0001 Baseline LLd 0.425 0.01 Baseline BPFc 0.551 0.0001 Baseline VFd 0.414 0.01 Baseline mean lesion MTR 0.148 0.34 Baseline mean NABT MTRc 0.511 0.001 Baseline EDSSc 0.273 0.07 0.326 0.001 LL change over 2 y 0.117 0.45 BPF change over 2 yd 0.435 0.01 VF change over 2 yc 0.545 0.0001 Mean lesion MTR change over 2 y 0.163 0.29 Mean NABT MTR change over 2 y 0.016 0.92