Driving efficiency in a high-throughput metabolic stability assay through a generic high-resolution accurate mass method and automated data mining
暂无分享,去创建一个
[1] Wilson Z Shou,et al. A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer. , 2005, Journal of mass spectrometry : JMS.
[2] Sean Yu,et al. Quantitation of small molecules using high-resolution accurate mass spectrometers - a different approach for analysis of biological samples. , 2009, Rapid communications in mass spectrometry : RCM.
[3] A. Makarov,et al. The Orbitrap: a new mass spectrometer. , 2005, Journal of mass spectrometry : JMS.
[4] Jennifer H Granger,et al. Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. , 2005, Rapid communications in mass spectrometry : RCM.
[5] L. Romanyshyn,et al. Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process. , 2002, Rapid communications in mass spectrometry : RCM.
[6] Sean Yu,et al. High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies. , 2008, Rapid communications in mass spectrometry : RCM.
[7] C. Bigogno,et al. New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies. , 2007, Journal of pharmaceutical and biomedical analysis.
[8] Wilson Z Shou,et al. Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms. , 2007, Rapid communications in mass spectrometry : RCM.
[9] Ari Tolonen,et al. Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds. , 2010, Rapid communications in mass spectrometry : RCM.
[10] Scott Peterman,et al. An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection. , 2008, Journal of mass spectrometry : JMS.
[11] Austin C Li,et al. Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. , 2009, Rapid communications in mass spectrometry : RCM.
[12] A. Nomeir,et al. Utility of mass spectrometry for in-vitro ADME assays. , 2006, Current drug metabolism.
[13] E. Nägele,et al. Simultaneous determination of metabolic stability and identification of buspirone metabolites using multiple column fast liquid chromatography time-of-flight mass spectrometry. , 2007, Journal of chromatography. A.
[14] Wilson Z Shou,et al. Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument. , 2005, Rapid communications in mass spectrometry : RCM.
[15] Olavi Pelkonen,et al. Liquid chromatography-mass spectrometry in in vitro drug metabolite screening. , 2009, Drug discovery today.
[16] Jie Chen,et al. Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60,000 in external calibration mode using an LTQ/Orbitrap. , 2007, Rapid communications in mass spectrometry : RCM.
[17] Desmond O'Connor,et al. Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data. , 2006, Rapid communications in mass spectrometry : RCM.
[18] Li Di,et al. Drug-like property concepts in pharmaceutical design. , 2009, Current pharmaceutical design.
[19] C E Hop,et al. Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery. , 1999, Rapid communications in mass spectrometry : RCM.
[20] Hongying Gao,et al. Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap. , 2007, Rapid communications in mass spectrometry : RCM.