Lewis Acid–Doped Natural Phosphate: New Catalysts for the One‐Pot Synthesis of 3,4‐Dihydropyrimdin‐2(1H)‐one

Abstract Inexpensive and readily available natural phosphate doped with metal halides is used to efficiently catalyze the three‐component condensation reaction of an aldehyde, a beta‐keto ester, and urea to afford the corresponding dihydropyrimidin‐2(1H)‐ones in high yields.

[1]  M. Shailaja,et al.  Simple Protocol for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones Using SnCl2 · 2H2O–LiCl as an Inexpensive Catalyst System , 2004 .

[2]  K. Nagaiah,et al.  Cadmium Chloride: An Efficient Catalyst for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones. , 2004 .

[3]  C. Kappe,et al.  The Biginelli Dihydropyrimidine Synthesis , 2004 .

[4]  J. S. Sandhu,et al.  A Novel Cu-Catalyzed Three-Component One-Pot Synthesis of Dihydropyrimidin-2(1H)-ones Using Microwaves under Solvent-Free Conditions. , 2004 .

[5]  K. Srinivasan,et al.  Ionic liquid promoted novel and efficient one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones at ambient temperature under ultrasound irradiation , 2004 .

[6]  S. Sebti,et al.  Natural phosphate doped with potassium fluoride: Efficient catalyst for the construction of a carbon-carbon bond , 2004 .

[7]  K. Nagaiah,et al.  Green Protocol for the Biginelli Three-Component Reaction: Ag3PW12O40 as a Novel, Water-Tolerant Heteropolyacid for the Synthesis of 3,4-Dihydropyrimidinones , 2004 .

[8]  Qiya Zhuang,et al.  A New Biginelli Reaction Procedure Using Potassium Hydrogen Sulfate as the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-one. , 2004 .

[9]  A. Mitra,et al.  Clay Catalysed Synthesis of Dihydropyrimidinones under Solvent-free Conditions , 2003 .

[10]  S. Sebti,et al.  Doped Natural Phosphate: A New and Environmentally Friendly Catalyst in Nucleoside Synthesis , 2003, Nucleosides, nucleotides & nucleic acids.

[11]  S. Sebti,et al.  Building Blocks for Polyamide Nucleic Acids: Facile Synthesis Using Potassium Fluoride Doped Natural Phosphate as Basic Catalyst , 2003, Nucleosides, nucleotides & nucleic acids.

[12]  J. Mayoral,et al.  Application of natural phosphate modified with sodium nitrate in the synthesis of chalcones: a soft and clean method , 2003 .

[13]  M. Mahesh,et al.  Zirconium(IV) chloride catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones☆ , 2002 .

[14]  S. Sebti,et al.  Natural phosphate doped with potassium fluoride and modified with sodium nitrate: efficient catalysts for the Knoevenagel condensation , 2002 .

[15]  D. Macquarrie,et al.  KF/natural phosphate as an efficient catalyst for synthesis of 2′-hydroxychalcones and flavanones , 2002 .

[16]  C. S. Reddy,et al.  Mn(OAc)3×2H2O‐Mediated Three‐Component, One‐Pot Condensation Reaction: An Efficient Synthesis of 4‐Aryl‐Substituted 3,4‐Dihydropyrimidin‐2‐ones. , 2002 .

[17]  J. Mayoral,et al.  Modified natural phosphates: easily accessible basic catalysts for the epoxidation of electron-deficient alkenes , 2001 .

[18]  A. Dondoni,et al.  Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction , 2001 .

[19]  C. S. Reddy,et al.  ChemInform Abstract: Mn(OAc)3×2H2O-Mediated Three-Component, One-Pot Condensation Reaction: An Efficient Synthesis of 4-Aryl-Substituted 3,4-Dihydropyrimidin-2-ones. , 2001 .

[20]  C. Kappe.  Biologically active dihydropyrimidones of the Biginelli-type--a literature survey. , 2000, European journal of medicinal chemistry.

[21]  S. Sebti,et al.  Zinc Chloride Doped Natural Phosphate as 1,3-Dipolar Cycloaddition Catalyst , 1999 .

[22]  S. Sebti,et al.  Catalyse hétérogène de l'hydratation des nitriles en amides par le phosphate naturel dopé par KF et le phosphate trisodique , 1996 .

[23]  SebtiSaïd,et al.  Heterogeneous Catalysis of the Friedel-Crafts Alkylation by Doped Natural Phosphate and Tricalcium Phosphate , 1996 .

[24]  S. Sebti,et al.  Synthse des a-hydroxyphosphonates sur des supports phosphats en absence de solvant , 1996 .

[25]  C. Kappe.  100 years of the biginelli dihydropyrimidine synthesis , 1993 .