Demonstration of in-vivo Multi-Probe Tracker Based on a Si/CdTe Semiconductor Compton Camera

By using a prototype Compton camera consisting of silicon (Si) and cadmium telluride (CdTe) semiconductor detectors, originally developed for the ASTRO-H satellite mission, an experiment involving imaging multiple radiopharmaceuticals injected into a living mouse was conducted to study its feasibility for medical imaging. The accumulation of both iodinated (131I) methylnorcholestenol and 85Sr into the mouse's organs was simultaneously imaged by the prototype. This result implies that the Compton camera is expected to become a multi-probe tracker available in nuclear medicine and small animal imaging.

[1]  R. Rohe,et al.  The spatially-variant back-projection point kernel function of an energy-subtraction Compton scatter camera for medical imaging , 1996, 1996 IEEE Nuclear Science Symposium. Conference Record.

[2]  T. Takahashi,et al.  Experimental Results of the Gamma-Ray Imaging Capability With a Si/CdTe Semiconductor Compton Camera , 2009, IEEE Transactions on Nuclear Science.

[3]  Shin Watanabe,et al.  Simulation study of 3-D gamma-ray imager with Si/CdTe semiconductor Compton camera , 2010, 2010 IEEE Sensors Applications Symposium (SAS).

[4]  Tadayuki Takahashi,et al.  High resolution CdTe detectors for the next-generation multi-Compton gamma-ray telescope , 2003, SPIE Astronomical Telescopes + Instrumentation.

[5]  Jeffrey A. Fessler,et al.  List-mode maximum likelihood reconstruction of Compton scatter camera images in nuclear medicine , 1998, 1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255).

[6]  H. Haba,et al.  Gamma-Ray Compton Imaging of Multitracer in Biological Samples Using Strip Germanium Telescope , 2007, IEEE Transactions on Nuclear Science.

[7]  Andreas Zoglauer,et al.  Doppler broadening as a lower limit to the angular resolution of next-generation Compton telescopes , 2003, SPIE Astronomical Telescopes + Instrumentation.

[8]  T. Takahashi,et al.  A Si/CdTe semiconductor Compton camera , 2004, IEEE Transactions on Nuclear Science.

[9]  P. Frost,et al.  Strontium-85 Scanning of Suspected Bone Disease , 1969, British medical journal.

[10]  Yoshiharu Namba,et al.  The ASTRO-H Mission , 2009, Astronomical Telescopes + Instrumentation.

[11]  J. M. Nightingale,et al.  A proposed γ camera , 1974, Nature.