Alginate-based microcapsules for immunoisolation of pancreatic islets.

[1]  B. Hering,et al.  Large-scale production of Ba(2+)-alginate-coated islets of Langerhans for immunoisolation. , 2009, Experimental and clinical endocrinology.

[2]  P. de Vos,et al.  Zeta-potentials of alginate-PLL capsules: a predictive measure for biocompatibility? , 2007, Journal of biomedical materials research. Part A.

[3]  J. Pedraz,et al.  Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy. , 2006, Biomaterials.

[4]  Denis Dufrane,et al.  The influence of implantation site on the biocompatibility and survival of alginate encapsulated pig islets in rats. , 2006, Biomaterials.

[5]  Ivan Donati,et al.  Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads. , 2006, Biomacromolecules.

[6]  P. Vos,et al.  Advances and Barriers in Mammalian Cell Encapsulation for Treatment of Diabetes , 2006 .

[7]  L. Yahia,et al.  Impact of residual contamination on the biofunctional properties of purified alginates used for cell encapsulation. , 2006, Biomaterials.

[8]  L. Yahia,et al.  Evaluation of alginate purification methods: effect on polyphenol, endotoxin, and protein contamination. , 2006, Journal of biomedical materials research. Part A.

[9]  E. Opara,et al.  The bioartificial pancreas: progress and challenges. , 2005, Diabetes technology & therapeutics.

[10]  L. Yahia,et al.  Physicochemical model of alginate-poly-L-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS. , 2005, Biomaterials.

[11]  R. Robitaille,et al.  Inflammatory response to peritoneal implantation of alginate-poly-L-lysine microcapsules. , 2005, Biomaterials.

[12]  F. Volke,et al.  Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation , 2005, Journal of materials science. Materials in medicine.

[13]  S. Capitani,et al.  Accelerated Functional Maturation of Isolated Neonatal Porcine Cell Clusters: In Vitro and In Vivo Results in NOD Mice , 2005, Cell transplantation.

[14]  A. Bikfalvi,et al.  Molecular mechanisms of tumor vascularization. , 2005, Critical reviews in oncology/hematology.

[15]  Synnøve Holtan,et al.  New hypothesis on the role of alternating sequences in calcium-alginate gels. , 2005, Biomacromolecules.

[16]  G. Weir,et al.  Long-Term Normoglycemia in Rats Receiving Transplants with Encapsulated Islets , 2005, Transplantation.

[17]  P. Brunetti,et al.  Optimized parameters for microencapsulation of pancreatic islet cells: an in vitro study clueing on islet graft immunoprotection in type 1 diabetes mellitus. , 2004, Transplant immunology.

[18]  P. de Vos,et al.  University of Groningen Factors influencing functional survival of microencapsulated islet grafts , 2004 .

[19]  Giovanni Luca,et al.  Grafts of microencapsulated pancreatic islet cells for the therapy of diabetes mellitus in non‐immunosuppressed animals , 2004, Biotechnology and applied biochemistry.

[20]  P. de Vos,et al.  Biocompatibility and surface structure of chemically modified immunoisolating alginate-PLL capsules. , 2003, Journal of biomedical materials research. Part A.

[21]  P. de Vos,et al.  Fourier transform infrared spectroscopy studies of alginate-PLL capsules with varying compositions. , 2003, Journal of biomedical materials research. Part A.

[22]  P. de Vos,et al.  Factors Influencing Insulin Secretion from Encapsulated Islets , 2003, Cell transplantation.

[23]  G. Skjåk-Bræk,et al.  The role of capsule composition and biologic responses in the function of transplanted microencapsulated islets of langerhans1 , 2003, Transplantation.

[24]  G. Skjåk‐Braek,et al.  Visualization of alginate-poly-L-lysine-alginate microcapsules by confocal laser scanning microscopy. , 2003, Biotechnology and bioengineering.

[25]  P. Vos,et al.  Association between macrophage activation and function of micro-encapsulated rat islets , 2003, Diabetologia.

[26]  P. de Vos,et al.  Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats , 2003, Xenotransplantation.

[27]  B. Kulseng,et al.  Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating. , 2003, Journal of biomedical materials research. Part A.

[28]  C. Mathieu,et al.  IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice , 2003, Diabetologia.

[29]  P. de Vos,et al.  Tissue responses against immunoisolating alginate-PLL capsules in the immediate posttransplant period. , 2002, Journal of biomedical materials research.

[30]  A. Bolzán,et al.  Genotoxicity of streptozotocin. , 2002, Mutation research.

[31]  S. Akira,et al.  Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers* , 2002, The Journal of Biological Chemistry.

[32]  P. de Vos,et al.  Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets. , 2002, Trends in molecular medicine.

[33]  Tejal A Desai,et al.  Microfabrication technology for pancreatic cell encapsulation , 2002, Expert opinion on biological therapy.

[34]  P. de Vos,et al.  Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells. , 2002, Journal of biomedical materials research.

[35]  P. de Vos,et al.  Considerations for successful transplantation of encapsulated pancreatic islets , 2002, Diabetologia.

[36]  A. King,et al.  The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules. , 2001, Journal of biomedical materials research.

[37]  A. Haase,et al.  A Novel Class of Amitogenic Alginate Microcapsules for Long‐Term Immunoisolated Transplantation , 2001, Annals of the New York Academy of Sciences.

[38]  V. Mow,et al.  Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial articular joints. , 2001, Journal of biomechanics.

[39]  G. Weir,et al.  Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. , 2001, Diabetes.

[40]  S. Bonner-Weir,et al.  ENHANCED MATURATION OF PORCINE NEONATAL PANCREATIC CELL CLUSTERS WITH GROWTH FACTORS FAILS TO IMPROVE TRANSPLANTATION OUTCOME1 , 2001, Transplantation.

[41]  P. de Vos,et al.  C-Peptide responses after meal challenge in mice transplanted with microencapsulated rat islets , 2001, Diabetologia.

[42]  P. de Vos,et al.  Microcapsules and their ability to protect islets against cytokine-mediated dysfunction. , 2001, Transplantation proceedings.

[43]  P. Marchetti,et al.  BOVINE ISLETS ARE LESS SUSCEPTIBLE THAN HUMAN ISLETS TO DAMAGE BY HUMAN CYTOKINES1 , 2001, Transplantation.

[44]  B. Říhová Immunocompatibility and biocompatibility of cell delivery systems. , 2000, Advanced drug delivery reviews.

[45]  P. Tresco,et al.  Technology of mammalian cell encapsulation. , 2000, Advanced drug delivery reviews.

[46]  A. King,et al.  Cytokine-induced functional suppression of microencapsulated rat pancreatic islets in vitro. , 2000, Transplantation.

[47]  G. Steil,et al.  Improved Vascularization of Planar Membrane Diffusion Devices following Continuous Infusion of Vascular Endothelial Growth Factor , 2000, Cell transplantation.

[48]  S. Bonner-Weir,et al.  Differentiation and Expansion of Beta Cell Mass in Porcine Neonatal Pancreatic Cell Clusters Transplanted into Nude Mice , 1999, Cell transplantation.

[49]  P. de Vos,et al.  Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth? , 1999, Diabetes.

[50]  J W Eaton,et al.  Natural Responses to Unnatural Materials: A Molecular Mechanism for Foreign Body Reactions , 1999, Molecular medicine.

[51]  J. Hubbell,et al.  In Vitro and in Vivo Performance of Porcine Islets Encapsulated in Interfacially Photopolymerized Poly(Ethylene Glycol) Diacrylate Membranes , 1999, Cell transplantation.

[52]  B. Kulseng,et al.  Transplantation of alginate microcapsules: generation of antibodies against alginates and encapsulated porcine islet-like cell clusters. , 1999, Transplantation.

[53]  B. Kulseng,et al.  Glucose metabolism in vitro of cultured and transplanted mouse pancreatic islets microencapsulated by means of a high-voltage electrostatic field. , 1999, Diabetes care.

[54]  Y. Kadoya,et al.  Measurements of zeta potentials of particulate biomaterials in protein-rich hyaluronan solution with changes in pH and protein constituents. , 1998, Journal of biomedical materials research.

[55]  P. de Vos,et al.  Insulin Levels After Portal and Systemic Insulin Infusion Differ in a Dose-Dependent Fashion , 1998, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[56]  Anderson,et al.  Host response to tissue engineered devices. , 1998, Advanced drug delivery reviews.

[57]  J W Eaton,et al.  Mast cells mediate acute inflammatory responses to implanted biomaterials. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Sitter,et al.  Amitogenic Alginates: Key to First Clinical Application of Microencapsulation Technology , 1998, World Journal of Surgery.

[59]  J. Hubbell,et al.  A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets. , 1998, Biotechnology and bioengineering.

[60]  M Rothmund,et al.  Parathyroid allotransplantation without immunosuppression , 1997, The Lancet.

[61]  P. Vos,et al.  Upscaling the production of microencapsulated pancreatic islets , 1997 .

[62]  B. Kulseng,et al.  Alginate polylysine microcapsules as immune barrier: permeability of cytokines and immunoglobulins over the capsule membrane. , 1997, Cell transplantation.

[63]  D. Pipeleers,et al.  Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets. , 1997, Transplantation.

[64]  G. Klöck,et al.  Biocompatibility of mannuronic acid-rich alginates. , 1997, Biomaterials.

[65]  G. Klöck,et al.  Collagen-coated Ba(2+)-alginate microcarriers for the culture of anchorage-dependent mammalian cells. , 1997, BioTechniques.

[66]  P. de Vos,et al.  Efficacy of a prevascularized expanded polytetrafluoroethylene solid support system as a transplantation site for pancreatic islets. , 1997, Transplantation.

[67]  R. Lanza,et al.  Immunoisolation: at a turning point. , 1997, Immunology today.

[68]  P. De Vos,et al.  Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets , 1997, Diabetologia.

[69]  P. de Vos,et al.  Impaired glucose tolerance in recipients of an intraperitoneally implanted microencapsulated islet allograft is caused by the slow diffusion of insulin through the peritoneal membrane. , 1997, Transplantation proceedings.

[70]  M. Rothmund,et al.  Transplantation of parathyroid tissue in experimental hypoparathyroidism: in vitro and in vivo function of parathyroid tissue microencapsulated with a novel amitogenic alginate , 1996, The International journal of artificial organs.

[71]  P. de Vos,et al.  Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. , 1996, Transplantation.

[72]  P. de Vos,et al.  Factors influencing the adequacy of microencapsulation of rat pancreatic islets. , 1996, Transplantation.

[73]  P. Bruheim,et al.  Alginate polycation microcapsules. II. Some functional properties. , 1996, Biomaterials.

[74]  Y. Yutani,et al.  The role of physicochemical properties of biomaterials and bacterial cell adhesion in vitro. , 1996, The International journal of artificial organs.

[75]  D. Ecker,et al.  A simple and inexpensive method for transplanting xenogeneic cells and tissues into rats using alginate gel spheres. , 1995, Transplantation proceedings.

[76]  J W Eaton,et al.  Inflammatory responses to biomaterials. , 1995, American journal of clinical pathology.

[77]  S. Bonner-Weir,et al.  Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model , 1995, Diabetes.

[78]  P. Aebischer,et al.  Chitosan as a matrix for mammalian cell encapsulation. , 1994, Biomaterials.

[79]  Y. Lepage,et al.  Studies on Small (<300 μm) Microcapsules: II — Parameters Governing the Production of Alginate Beads by High Voltage Electrostatic Pulses , 1994, Cell transplantation.

[80]  R. Lanza,et al.  Xenogenic humoral responses to islets transplanted in biohybrid diffusion chambers. , 1994, Transplantation.

[81]  L. Kunz,et al.  Effect of microencapsulation on oxygen distribution in islets organs. , 1994, Transplantation.

[82]  P. Soon-Shiong,et al.  Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation , 1994, The Lancet.

[83]  P. Aebischer,et al.  Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells , 1994, Experimental Neurology.

[84]  P. de Vos,et al.  Possible relationship between fibrotic overgrowth of alginate-polylysine-alginate microencapsulated pancreatic islets and the microcapsule integrity. , 1994, Transplantation proceedings.

[85]  D. A. Cieslinski,et al.  Tissue engineering of a bioartificial kidney , 1994, Biotechnology and bioengineering.

[86]  P. Chang,et al.  Delivery of recombinant gene products with microencapsulated cells in vivo. , 1993, Human gene therapy.

[87]  T. Chang,et al.  Secretion of Erythropoietin from Microencapsulated Rat Kidney Cells: Preliminary Results , 1993, The International journal of artificial organs.

[88]  P. Chang,et al.  Expression of human factor IX by microencapsulated recombinant fibroblasts. , 1993, Human gene therapy.

[89]  P. de Vos,et al.  Obstacles in the Application of Microencapsulation in Islet Transplantation , 1993, The International journal of artificial organs.

[90]  J. Remon,et al.  Host Reaction against Empty Alginate‐polylysine Microcapsules. Influence of Preparation Procedure , 1993, The Journal of pharmacy and pharmacology.

[91]  C. Colton,et al.  Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans , 1993, Diabetes.

[92]  P. Soon-Shiong,et al.  Long-term reversal of diabetes in the large animal model by encapsulated islet transplantation. , 1992, Transplantation proceedings.

[93]  A. Fournier,et al.  Studies of 300-microns microcapsules: I. Use of arginine esterase release by microencapsulated prostatic cells as a measure of membrane permeability. , 1992, Transplantation proceedings.

[94]  R. Bretzel,et al.  Lymphoid activation by different crude alginates and the effect of purification. , 1992, Transplantation proceedings.

[95]  L. Kunz,et al.  The role of oxygen supply in islet transplantation. , 1992, Transplantation proceedings.

[96]  R. Schnettler,et al.  Barium-alginate beads for immunoisolated transplantation of islets of Langerhans. , 1992, Transplantation proceedings.

[97]  A. Sun,et al.  Xenografts of rat islets into diabetic mice. An evaluation of new smaller capsules. , 1992, Transplantation.

[98]  B. Hering,et al.  In vitro testing of rat and porcine islets microencapsulated in barium alginate beads. , 1992, Transplantation proceedings.

[99]  P. Bruheim,et al.  Distribution of uronate residues in alginate chains in relation to alginate gelling properties , 1991 .

[100]  P. Déjardin,et al.  In vitro and in vivo studies of the properties of an artificial membrane for pancreatic islet encapsulation. , 1991, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[101]  G. Skjåk‐Braek,et al.  An immunologic basis for the fibrotic reaction to implanted microcapsules. , 1991, Transplantation proceedings.

[102]  G. Wolters,et al.  Effect of Alginate-Polylysine-Alginate Microencapsulation on In Vitro Insulin Release From Rat Pancreatic Islets , 1991, Diabetes.

[103]  P. Brunetti,et al.  Xenotransplantation of microencapsulated pancreatic islets contained in a vascular prosthesis: preliminary results , 1991, Transplant international : official journal of the European Society for Organ Transplantation.

[104]  M. Yarmush,et al.  Effect of oxygen on isolated pancreatic tissue. , 1989, ASAIO transactions.

[105]  G. Skjåk-Bræk,et al.  Alginate as immobilization material. II: Determination of polyphenol contaminants by fluorescence spectroscopy, and evaluation of methods for their removal , 1989, Biotechnology and bioengineering.

[106]  G. Skjåk-Bræk,et al.  Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads , 1989, Biotechnology and bioengineering.

[107]  H. Iwata,et al.  Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas by Studies of Hormone Secretion in Culture and by Xenotransplantation , 1989, Diabetes.

[108]  M. Goosen,et al.  Alginate‐Polylysine Microcapsules of Controlled Membrane Molecular Weight Cutoff for Mammalian Cell Culture Engineering , 1987 .

[109]  R. L. Broughton,et al.  Microencapsulation of CHO cells in a hydroxyethyl methacrylate-methyl methacrylate copolymer. , 1987, Biomaterials.

[110]  H. Wong,et al.  Bioartificial Liver: Implanted Artificial Cells Microencapsulated Living Hepatocytes Increases Survival of Liver Failure Rats , 1986, The International journal of artificial organs.

[111]  P. Aebischer,et al.  A bioartificial parathyroid. , 1986, ASAIO transactions.

[112]  J. P. Freyer,et al.  Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. , 1986, British Journal of Cancer.

[113]  F. Lim,et al.  Microencapsulated islets as bioartificial endocrine pancreas. , 1980, Science.

[114]  Giovanni Luca,et al.  Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. , 2006, Diabetes care.

[115]  D. Walsh,et al.  Osteoarthritis, angiogenesis and inflammation. , 2005, Rheumatology.

[116]  A. Vasconcellos,et al.  Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys. , 2005, Transplantation proceedings.

[117]  G. Klöck,et al.  Production of purified alginates suitable for use in immunoisolated transplantation , 2004, Applied Microbiology and Biotechnology.

[118]  P. de Vos,et al.  Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets. , 2003, Biomaterials.

[119]  C. Mathieu,et al.  IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. , 2003, Diabetologia.

[120]  S. Bonner-Weir,et al.  Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. , 2003, Diabetes.

[121]  B. Kulseng,et al.  Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines. , 2001, Cell transplantation.

[122]  R. Lanza,et al.  Cell Encapsulation Technology and Therapeutics , 1999, Birkhäuser Boston.

[123]  J. Hunt,et al.  Techniques to investigate cellular and molecular interactions in the host response to implanted biomaterials. , 1997, Biomaterials.

[124]  P. de Vos,et al.  Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules. , 1997, Biomaterials.

[125]  P. Bruheim,et al.  Alginate polycation microcapsules. I. Interaction between alginate and polycation. , 1996, Biomaterials.

[126]  P. de Vos,et al.  Kinetics of intraperitoneally infused insulin in rats. Functional implications for the bioartificial pancreas. , 1996, Diabetes.

[127]  B. Dupuy,et al.  FT-IR of membranes made with alginate/polylysine complexes. Variations with the mannuronic or guluronic content of the polysaccharides. , 1994, Artificial cells, blood substitutes, and immobilization biotechnology.

[128]  K Hannig,et al.  Production of mitogen‐contamination free alginates with variable ratios of mannuronic acid to guluronic acid by free flow electrophoresis , 1992, Electrophoresis.

[129]  H. Clayton,et al.  The effect of capsule composition on the biocompatibility of alginate-poly-l-lysine capsules. , 1991, Journal of microencapsulation.

[130]  S. Bystrický,et al.  Interaction of acidic polysaccharides with polylysine enantiomers. Conformation probe in solution , 1991 .

[131]  S. Bystrický,et al.  Interaction of alginates and pectins with cationic polypeptides , 1990 .

[132]  G. Skjåk-Bræk,et al.  Alginate as immobilization matrix for cells. , 1990, Trends in biotechnology.

[133]  R. Sutherland,et al.  Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. , 1982, Cancer research.

[134]  O. Smidsrod,et al.  Molecular basis for some physical properties of alginates in the gel state , 1974 .

[135]  A. Haug,et al.  The Solubility of Alginate at Low pH. , 1963 .