Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels

[1]  R. Hampson,et al.  Endocannabinoid tone versus constitutive activity of cannabinoid receptors , 2011, British journal of pharmacology.

[2]  Z. Xi,et al.  Brain Cannabinoid CB2 Receptors Modulate Cocaine’s Actions in Mice , 2011, Nature Neuroscience.

[3]  P Pacher,et al.  Is lipid signaling through cannabinoid 2 receptors part of a protective system? , 2011, Progress in lipid research.

[4]  G. Velasco,et al.  A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma , 2011, Molecular Cancer Therapeutics.

[5]  P. Goadsby,et al.  TRPV1 receptor blockade is ineffective in different in vivo models of migraine , 2011, Cephalalgia : an international journal of headache.

[6]  Stephen P. H. Alexander,et al.  International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 , 2010, Pharmacological Reviews.

[7]  A. Patapoutian,et al.  TRPA1 Contributes to Cold Hypersensitivity , 2010, The Journal of Neuroscience.

[8]  J. Gertsch,et al.  Phytocannabinoids beyond the Cannabis plant – do they exist? , 2010, British journal of pharmacology.

[9]  A. Izzo,et al.  Cannabinoids and the gut: new developments and emerging concepts. , 2010, Pharmacology & therapeutics.

[10]  L. Petrocellis,et al.  Role of endocannabinoids and endovanilloids in Ca2+ signalling. , 2009 .

[11]  M. Cascio,et al.  Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. , 2009, Journal of medicinal chemistry.

[12]  N. Stella,et al.  The therapeutic potential of novel cannabinoid receptors. , 2009, Pharmacology & therapeutics.

[13]  J. Caldwell,et al.  Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay , 2009, Journal of Biological Chemistry.

[14]  T. Kowalski,et al.  GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis. , 2009, The Journal of endocrinology.

[15]  A. Akopian,et al.  TRPA1‐mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1 , 2009, The European journal of neuroscience.

[16]  G. Bidaux,et al.  Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. , 2009, Biochimica et Biophysica Acta.

[17]  P. Robledo,et al.  Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons , 2009, Neuropharmacology.

[18]  R. Ross.  The enigmatic pharmacology of GPR55. , 2009, Trends in pharmacological sciences.

[19]  P. Brubaker,et al.  GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell , 2009, Diabetes.

[20]  A. Akopian,et al.  Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. , 2009, Trends in pharmacological sciences.

[21]  V. Marzo,et al.  Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels , 2009, Neuropsychopharmacology.

[22]  A. Irving,et al.  The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  D. R. Sagar,et al.  Inhibition of fatty acid amide hydrolase produces PPAR‐α‐mediated analgesia in a rat model of inflammatory pain , 2008, British journal of pharmacology.

[24]  C. Stucky,et al.  Constitutive Activity at the Cannabinoid CB1 Receptor Is Required for Behavioral Response to Noxious Chemical Stimulation of TRPV1: Antinociceptive Actions of CB1 Inverse Agonists , 2008, The Journal of Neuroscience.

[25]  B. Costa,et al.  The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors , 2008, PAIN.

[26]  A. Yamashita,et al.  2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55. , 2008, Journal of biochemistry.

[27]  I. Chessell,et al.  The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain , 2008, PAIN.

[28]  Takeshi Saito,et al.  Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. , 2008, European journal of pharmacology.

[29]  Xiang-Qun Xie,et al.  Beta-caryophyllene is a dietary cannabinoid , 2008, Proceedings of the National Academy of Sciences.

[30]  T. Hutchinson,et al.  TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons , 2008, The Journal of Neuroscience.

[31]  V. Vellani,et al.  Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8 , 2008, Journal of Pharmacology and Experimental Therapeutics.

[32]  Markus Waldeck-Weiermair,et al.  Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression , 2008, Journal of Cell Science.

[33]  B. Nilius,et al.  Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators , 2008, Pflügers Archiv - European Journal of Physiology.

[34]  M. Maccarrone,et al.  FAAH and anandamide: is 2-AG really the odd one out? , 2008, Trends in pharmacological sciences.

[35]  Robert M. Jones,et al.  A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. , 2008, Endocrinology.

[36]  A. Akopian,et al.  Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors , 2008, PAIN.

[37]  K. Mackie,et al.  GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current , 2008, Proceedings of the National Academy of Sciences.

[38]  L. Petrocellis,et al.  Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain , 2008, Neuroscience.

[39]  D. Centonze,et al.  Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum , 2008, Nature Neuroscience.

[40]  V. Marzo,et al.  Why endocannabinoids are not all alike , 2008, Nature Neuroscience.

[41]  A. Akopian,et al.  Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation , 2008, The Journal of Neuroscience.

[42]  A. Mallat,et al.  CB2 receptors as new therapeutic targets for liver diseases , 2008, British journal of pharmacology.

[43]  A. Hohmann,et al.  Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain , 2008, British journal of pharmacology.

[44]  D. Lovinger,et al.  Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step , 2007, Proceedings of the National Academy of Sciences.

[45]  B. Hudson,et al.  Agonist‐dependent cannabinoid receptor signalling in human trabecular meshwork cells , 2007, British journal of pharmacology.

[46]  R. Pertwee.  GPR55: a new member of the cannabinoid receptor clan? , 2007, British journal of pharmacology.

[47]  S. Hjorth,et al.  The orphan receptor GPR55 is a novel cannabinoid receptor , 2007, British journal of pharmacology.

[48]  A. Yamashita,et al.  Identification of GPR55 as a lysophosphatidylinositol receptor. , 2007, Biochemical and biophysical research communications.

[49]  C. Hiley,et al.  GPR55 and the vascular receptors for cannabinoids , 2007, British journal of pharmacology.

[50]  S. O'Sullivan,et al.  Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors , 2007, British journal of pharmacology.

[51]  S. Dowell,et al.  The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects , 2007, British journal of pharmacology.

[52]  Stephen P. H. Alexander,et al.  Cannabinoid activation of PPARα; a novel neuroprotective mechanism , 2007 .

[53]  D. Corey,et al.  An Ion Channel Essential for Sensing Chemical Damage , 2007, The Journal of Neuroscience.

[54]  P. Calabresi,et al.  Sensitization, glutamate, and the link between migraine and fibromyalgia , 2007, Current pain and headache reports.

[55]  R. Latorre,et al.  ThermoTRP channels as modular proteins with allosteric gating. , 2007, Cell calcium.

[56]  Michael Zhao,et al.  TRPA1 mediates formalin-induced pain , 2007, Proceedings of the National Academy of Sciences.

[57]  A. Basbaum,et al.  4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 , 2007, Proceedings of the National Academy of Sciences.

[58]  A. Akopian,et al.  Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1‐directed internalization , 2007, The Journal of physiology.

[59]  J. Levine,et al.  TRP channels: targets for the relief of pain. , 2007, Biochimica et biophysica acta.

[60]  D. Piomelli,et al.  Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. , 2007, European journal of pharmacology.

[61]  Feng Hao,et al.  Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. , 2007, Biochimica et biophysica acta.

[62]  Didier Bagnol,et al.  A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. , 2007, Endocrinology.

[63]  P. Calabresi,et al.  Endocannabinoids in Chronic Migraine: CSF Findings Suggest a System Failure , 2007, Neuropsychopharmacology.

[64]  V. Di Marzo,et al.  Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. , 2007, Experimental cell research.

[65]  G. Gisselmann,et al.  Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions* , 2007, Journal of Biological Chemistry.

[66]  T. Holzman,et al.  Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597) , 2007, Molecular Pharmacology.

[67]  S. Petrosino,et al.  Endocannabinoids and the regulation of their levels in health and disease , 2007, Current opinion in lipidology.

[68]  P. Heppenstall,et al.  Direct activation of the ion channel TRPA1 by Ca2+ , 2007, Nature Neuroscience.

[69]  R. Pertwee,et al.  Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro , 2007, British journal of pharmacology.

[70]  Peter G. Schultz,et al.  Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines , 2007, Nature.

[71]  J. Levine,et al.  Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice , 2007, The Journal of physiology.

[72]  L. Petrocellis,et al.  Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain , 2006, Neuroscience.

[73]  Y. Panchin,et al.  Ca2+-independent Phospholipase A2-dependent Gating of TRPM8 by Lysophospholipids* , 2006, Journal of Biological Chemistry.

[74]  D. Julius,et al.  TRP channel activation by reversible covalent modification , 2006, Proceedings of the National Academy of Sciences.

[75]  M. Itakura,et al.  Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells. , 2006, Biochemical and biophysical research communications.

[76]  Stephen P. H. Alexander,et al.  Cannabinoids and PPARα signalling , 2006 .

[77]  P. Pacher,et al.  The Endocannabinoid System as an Emerging Target of Pharmacotherapy , 2006, Pharmacological Reviews.

[78]  I. Matias,et al.  Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma , 2006, Journal of Pharmacology and Experimental Therapeutics.

[79]  H. Anderson,et al.  Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain , 2006, Current Biology.

[80]  J. V. Vanden Heuvel,et al.  Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2 , 2006, Molecular Pharmacology.

[81]  D. Clapham,et al.  Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels , 2006, Nature Neuroscience.

[82]  K. Mackie,et al.  Cannabinoid receptors and endocannabinoids: Evidence for new players , 2006, The AAPS Journal.

[83]  K. Mackie,et al.  Cannabinoid receptors and endocannabinoids , 2006 .

[84]  Clifford J. Woolf,et al.  TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction , 2006, Neuron.

[85]  J. Levine,et al.  A Transient Receptor Potential Vanilloid 4-Dependent Mechanism of Hyperalgesia Is Engaged by Concerted Action of Inflammatory Mediators , 2006, The Journal of Neuroscience.

[86]  D. Malone,et al.  Cannabidiol Reverses MK-801-Induced Disruption of Prepulse Inhibition in Mice , 2006, Neuropsychopharmacology.

[87]  David Julius,et al.  TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents , 2006, Cell.

[88]  C. Reynet,et al.  Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. , 2006, Cell metabolism.

[89]  M. Cascio,et al.  Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. , 2006, Journal of medicinal chemistry.

[90]  C. Vaughan.  Stressed-out endogenous cannabinoids relieve pain. , 2006, Trends in pharmacological sciences.

[91]  J. Gu,et al.  Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons. , 2006, Journal of neurophysiology.

[92]  Yi Dai,et al.  Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors , 2005, The Journal of comparative neurology.

[93]  T. Cassano,et al.  Correction for Gobbi et al., Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[94]  S. Pingle,et al.  Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation , 2005, The Journal of Neuroscience.

[95]  B. Birnir,et al.  Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists* , 2005, Journal of Biological Chemistry.

[96]  A. Christopoulos,et al.  Allosteric Modulation of the Cannabinoid CB1 Receptor , 2005, Molecular Pharmacology.

[97]  R. Busse,et al.  Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium , 2005, Circulation research.

[98]  E. Bertoli,et al.  On the importance of anandamide structural features for its interactions with DPPC bilayers: effects on PLA2 activity Published, JLR Papers in Press, June 16, 2005. DOI 10.1194/jlr.M500121-JLR200 , 2005, Journal of Lipid Research.

[99]  B. Gorzalka,et al.  Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression? , 2005, Behavioural pharmacology.

[100]  Olov Sterner,et al.  Pungent products from garlic activate the sensory ion channel TRPA1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[101]  L. Petrocellis,et al.  Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. , 2005 .

[102]  Roberto Russo,et al.  The search for the palmitoylethanolamide receptor. , 2005, Life sciences.

[103]  P. Casellas,et al.  Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. , 2005, European journal of pharmacology.

[104]  C. Hillard,et al.  Accumulation of anandamide: Evidence for cellular diversity , 2005, Neuropharmacology.

[105]  J. Monnin,et al.  Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions. , 2005, Rhinology.

[106]  S. Gaetani,et al.  Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats , 2005, Neuropharmacology.

[107]  A. Patapoutian,et al.  The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin , 2005, Current Biology.

[108]  Beiying Liu,et al.  Functional Recovery from Desensitization of Vanilloid Receptor TRPV1 Requires Resynthesis of Phosphatidylinositol 4,5-Bisphosphate , 2005, The Journal of Neuroscience.

[109]  D. Osei-Hyiaman,et al.  Evidence for novel cannabinoid receptors. , 2005, Pharmacology & therapeutics.

[110]  K. Nagata,et al.  Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing , 2005, The Journal of Neuroscience.

[111]  D. Mohapatra,et al.  Regulation of Ca2+-dependent Desensitization in the Vanilloid Receptor TRPV1 by Calcineurin and cAMP-dependent Protein Kinase* , 2005, Journal of Biological Chemistry.

[112]  G. Ahern,et al.  Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short‐term food intake in mice via capsaicin receptor TRPV1 , 2005, The Journal of physiology.

[113]  N. Ueda,et al.  Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase* , 2005, Journal of Biological Chemistry.

[114]  Beiying Liu,et al.  Functional Control of Cold- and Menthol-Sensitive TRPM8 Ion Channels by Phosphatidylinositol 4,5-Bisphosphate , 2005, The Journal of Neuroscience.

[115]  H. Matsushime,et al.  Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. , 2005, Biochemical and biophysical research communications.

[116]  D. McKemy,et al.  Molecular Pain BioMed Central Review , 2005 .

[117]  D. Piomelli,et al.  The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide , 2005, Molecular Pharmacology.

[118]  Heidi L. Rehm,et al.  TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells , 2004, Nature.

[119]  A. Suter,et al.  Echinacea alkylamides modulate TNF‐α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways , 2004, FEBS letters.

[120]  Joachim Klosterkötter,et al.  Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms , 2004, Neuropsychopharmacology.

[121]  M. Tominaga,et al.  Thermosensation and pain. , 2004, Journal of neurobiology.

[122]  D. Julius,et al.  The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel , 2004, Neuron.

[123]  V. Di Marzo,et al.  Actions of two naturally occurring saturated N‐acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels , 2004, British journal of pharmacology.

[124]  B. Costa,et al.  Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation , 2004, British journal of pharmacology.

[125]  M. Zhu,et al.  2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3* , 2004, Journal of Biological Chemistry.

[126]  J. Satoh,et al.  Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia* , 2004, Journal of Biological Chemistry.

[127]  Bernd Nilius,et al.  The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels , 2004, Nature.

[128]  P. Goadsby,et al.  Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors , 2004, British journal of pharmacology.

[129]  D. Piomelli,et al.  Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor α (PPAR-α)* , 2004, Journal of Biological Chemistry.

[130]  W. S. Ho,et al.  Vasorelaxant activities of the putative endocannabinoid virodhamine in rat isolated small mesenteric artery , 2004, The Journal of pharmacy and pharmacology.

[131]  D. Kendall,et al.  Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non‐CB1/CB2 Gi/o linked receptor , 2004, British Journal of Pharmacology.

[132]  A. Astrup,et al.  Food intake is inhibited by oral oleoylethanolamide Published, JLR Papers in Press, April 1, 2004. DOI 10.1194/jlr.C300008-JLR200 , 2004, Journal of Lipid Research.

[133]  A. Akopian,et al.  Cannabinoid receptor‐independent actions of the aminoalkylindole WIN 55,212‐2 on trigeminal sensory neurons , 2004, British journal of pharmacology.

[134]  L. Petrocellis,et al.  Prostaglandin Ethanolamides (Prostamides): In Vitro Pharmacology and Metabolism , 2004, Journal of Pharmacology and Experimental Therapeutics.

[135]  A. Akopian,et al.  Modulation of trigeminal sensory neuron activity by the dual cannabinoid–vanilloid agonists anandamide, N‐arachidonoyl‐dopamine and arachidonyl‐2‐chloroethylamide , 2004, British journal of pharmacology.

[136]  A. Patapoutian,et al.  Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin , 2004, Neuron.

[137]  P. Greasley,et al.  Screening tests for cannabinoid-ligand-like modulators of GPR55 , 2004 .

[138]  R. Jostock,et al.  Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay , 2004, British journal of pharmacology.

[139]  D. McKemy,et al.  Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 , 2004, Nature.

[140]  David E. Clapham,et al.  TRP channels as cellular sensors , 2003, Nature.

[141]  David E. Gloriam,et al.  Seven evolutionarily conserved human rhodopsin G protein‐coupled receptors lacking close relatives , 2003, FEBS letters.

[142]  D. Lovinger,et al.  Emerging roles for endocannabinoids in long‐term synaptic plasticity , 2003, British journal of pharmacology.

[143]  S. Gaetani,et al.  Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α , 2003, Nature.

[144]  T. Bisogno,et al.  Possible endocannabinoid control of colorectal cancer growth. , 2003, Gastroenterology.

[145]  D. Greenberg,et al.  Palmitoylethanolamide Increases after Focal Cerebral Ischemia and Potentiates Microglial Cell Motility , 2003, The Journal of Neuroscience.

[146]  G. Ahern.  Activation of TRPV1 by the Satiety Factor Oleoylethanolamide* , 2003, Journal of Biological Chemistry.

[147]  N. Stella,et al.  Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. , 2003, European journal of pharmacology.

[148]  D. McKemy,et al.  Lessons from peppers and peppermint: the molecular logic of thermosensation , 2003, Current Opinion in Neurobiology.

[149]  B. Nilius,et al.  Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels , 2003, Nature.

[150]  M. Caterina,et al.  TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat. , 2003, Journal of neurophysiology.

[151]  I. Grant,et al.  Non-acute (residual) neurocognitive effects of cannabis use: A meta-analytic study , 2003, Journal of the International Neuropsychological Society.

[152]  Hui Li,et al.  Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. , 2003, Molecular pharmacology.

[153]  L. Petrocellis,et al.  N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia* , 2003, The Journal of Biological Chemistry.

[154]  E. Bertoli,et al.  Different modulation of phospholipase A2 activity by saturated and monounsaturated N-acylethanolamines Published, JLR Papers in Press, January 16, 2003. DOI 10.1194/jlr.M200395-JLR200 , 2003, Journal of Lipid Research.

[155]  David M. Lovinger,et al.  It could be habit forming: drugs of abuse and striatal synaptic plasticity , 2003, Trends in Neurosciences.

[156]  Peter McIntyre,et al.  ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures , 2003, Cell.

[157]  L. Petrocellis,et al.  Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response , 2003, Cellular and Molecular Life Sciences CMLS.

[158]  R. Razdan,et al.  Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. , 2003, Molecular pharmacology.

[159]  G. Brand,et al.  Sensitization and desensitization to allyl isothiocyanate (mustard oil) in the nasal cavity. , 2002, Chemical senses.

[160]  D. J. Brasier,et al.  cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation , 2002, Neuron.

[161]  A. Minassi,et al.  N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor. , 2002, Journal of medicinal chemistry.

[162]  Rajnish A. Gupta,et al.  15-Lipoxygenase Metabolism of 2-Arachidonylglycerol , 2002, The Journal of Biological Chemistry.

[163]  C. Kwan,et al.  Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction. , 2002, Life sciences.

[164]  Pierangelo Geppetti,et al.  An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[165]  B. Staels,et al.  PPARs: Transcription Factors Controlling Lipid and Lipoprotein Metabolism , 2002, Annals of the New York Academy of Sciences.

[166]  F. Bymaster,et al.  Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. , 2002, The Journal of pharmacology and experimental therapeutics.

[167]  D. Andersson,et al.  Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. , 2002, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[168]  M. Parmentier,et al.  Novel, not adenylyl cyclase-coupled cannabinoid binding site in cerebellum of mice. , 2002, Biochemical and biophysical research communications.

[169]  P. McIntyre,et al.  A TRP Channel that Senses Cold Stimuli and Menthol , 2002, Cell.

[170]  D. McKemy,et al.  Identification of a cold receptor reveals a general role for TRP channels in thermosensation , 2002, Nature.

[171]  C. Fowler,et al.  The palmitoylethanolamide family: a new class of anti-inflammatory agents? , 2002, Current medicinal chemistry.

[172]  David Julius,et al.  Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers , 2002, Cell.

[173]  V. Di Marzo,et al.  Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors , 2001, FEBS letters.

[174]  D. Ponde,et al.  Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide , 2001, British journal of pharmacology.

[175]  T. Freund,et al.  Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus , 2001, Neuroscience.

[176]  L. Petrocellis,et al.  Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. , 2001, The Biochemical journal.

[177]  L. Petrocellis,et al.  Anandamide: some like it hot. , 2001, Trends in pharmacological sciences.

[178]  C. Breivogel,et al.  Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. , 2001, Molecular pharmacology.

[179]  M. Shapero,et al.  Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. , 2001, Cancer research.

[180]  A. Finazzi-Agro’,et al.  The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism* , 2001, The Journal of Biological Chemistry.

[181]  R. Nicoll,et al.  Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses , 2001, Nature.

[182]  M. Elphick,et al.  The neurobiology and evolution of cannabinoid signalling. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[183]  Z. Vogel,et al.  2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[184]  C. Breivogel,et al.  Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice , 2000 .

[185]  T. Bisogno,et al.  Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity , 2000, FEBS letters.

[186]  B. Staels,et al.  Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation , 2000, Inflammation Research.

[187]  V. Marzo,et al.  New perspectives on enigmatic vanilloid receptors , 2000, Trends in Neurosciences.

[188]  A I Basbaum,et al.  Impaired nociception and pain sensation in mice lacking the capsaicin receptor. , 2000, Science.

[189]  P. Blumberg,et al.  Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[190]  D. Julius,et al.  Anandamide - the other side of the coin. , 2000, Trends in pharmacological sciences.

[191]  J. Chambers,et al.  The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1) , 2000, British journal of pharmacology.

[192]  T. Bonner,et al.  Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[193]  T. Bisogno,et al.  Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. , 1999, Biochemical and biophysical research communications.

[194]  R. Pertwee,et al.  Pharmacology of cannabinoid receptor ligands. , 1999, Current medicinal chemistry.

[195]  D. Julius,et al.  Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide , 1999, Nature.

[196]  A. Hohmann,et al.  The neurobiology of cannabinoid analgesia. , 1999, Life sciences.

[197]  M. Herkenham,et al.  Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[198]  D. Julius,et al.  A capsaicin-receptor homologue with a high threshold for noxious heat , 1999, Nature.

[199]  H. Heng,et al.  Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. , 1999, Brain research. Molecular brain research.

[200]  J. Glowinski,et al.  Anandamide and WIN 55212‐2 inhibit cyclic AMP formation through G‐protein‐coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes , 1999, The European journal of neuroscience.

[201]  M. Parmentier,et al.  Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. , 1999, Science.

[202]  T. Bisogno,et al.  Interactions between synthetic vanilloids and the endogenous cannabinoid system , 1998, FEBS letters.

[203]  H. Fields,et al.  An analgesia circuit activated by cannabinoids , 1998, Nature.

[204]  L. Petrocellis,et al.  An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. , 1998, European journal of pharmacology.

[205]  D. Piomelli,et al.  Control of pain initiation by endogenous cannabinoids , 1998, Nature.

[206]  A. Rice,et al.  The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain , 1998, Pain.

[207]  D. R. Compton,et al.  Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain. , 1998, The Journal of pharmacology and experimental therapeutics.

[208]  J. D. Richardson,et al.  Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors , 1998, Pain.

[209]  M. Bushnell,et al.  Temporal and qualitative properties of cold pain and heat pain: a psychophysical study , 1998, Pain.

[210]  J. D. Richardson,et al.  Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia , 1998, The Journal of Neuroscience.

[211]  K. Gallagher,et al.  The therapeutic potential of novel anticoagulants. , 1997, Expert opinion on investigational drugs.

[212]  D. Julius,et al.  The capsaicin receptor: a heat-activated ion channel in the pain pathway , 1997, Nature.

[213]  L. F. Kolakowski,et al.  A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. , 1997, Biochemical and biophysical research communications.

[214]  T. Bisogno,et al.  Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes* , 1997, The Journal of Biological Chemistry.

[215]  J. D. Richardson,et al.  SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice. , 1997, European journal of pharmacology.

[216]  A. Yamashita,et al.  2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. , 1995, Biochemical and biophysical research communications.

[217]  A. Fontana,et al.  Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone'. , 1995, Prostaglandins, leukotrienes, and essential fatty acids.

[218]  Z. Vogel,et al.  Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. , 1995, Biochemical pharmacology.

[219]  M. Debatis,et al.  Phospholipase participation in cannabinoid-induced release of free arachidonic acid. , 1994, Biochemical pharmacology.

[220]  S. Bevan,et al.  Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region". , 1993, Journal of medicinal chemistry.

[221]  S. Bevan,et al.  Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region". , 1993, Journal of medicinal chemistry.

[222]  R. Mechoulam,et al.  Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. , 1993, European journal of pharmacology.

[223]  D. Gibson,et al.  Isolation and structure of a brain constituent that binds to the cannabinoid receptor. , 1992, Science.

[224]  C. Raman,et al.  Identification and Cloning of Rabbit CD5 , 1992, Annals of the New York Academy of Sciences.

[225]  C. Maggi,et al.  Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents , 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

[226]  A. Howlett,et al.  Determination and characterization of a cannabinoid receptor in rat brain. , 1988, Molecular pharmacology.

[227]  F. Evans,et al.  Activation of phospholipase A2 by cannabinoids , 1987, FEBS letters.

[228]  S. Burstein,et al.  Prostaglandins and Cannabis—VIII. Elevation of Phospholipase A2 Activity by Cannabinoids in Whole Cells and Subcellular Preparations , 1981, Journal of clinical pharmacology.

[229]  H. White,et al.  Effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism. , 1980, Prostaglandins and medicine.

[230]  C. Montell,et al.  TRP Channels , 2019, Methods in Molecular Biology.

[231]  Bernd Nilius,et al.  Vanilloid transient receptor potential cation channels: an overview. , 2008, Current pharmaceutical design.

[232]  A. Minassi,et al.  The role of natural products in the ligand deorphanization of TRP channels. , 2008, Current pharmaceutical design.

[233]  R. Pertwee.  The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. , 2008, British journal of pharmacology.

[234]  Stephen P. H. Alexander,et al.  Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. , 2007, British journal of pharmacology.

[235]  小林 希実子.  Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors , 2007 .

[236]  P. Calabresi,et al.  Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels , 2007, European Journal of Clinical Pharmacology.

[237]  Stephen P. H. Alexander,et al.  Cannabinoids and PPARalpha signalling. , 2006, Biochemical Society transactions.

[238]  D. Baker,et al.  In silico patent searching reveals a new cannabinoid receptor. , 2006, Trends in pharmacological sciences.

[239]  F. Fezza,et al.  Endocannabinoids in adipocytes during differentiation and their role in glucose uptake , 2006, Cellular and Molecular Life Sciences.

[240]  M. Oz.  Receptor-independent effects of endocannabinoids on ion channels. , 2006, Current pharmaceutical design.

[241]  D. Piomelli,et al.  Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). , 2004, The Journal of biological chemistry.

[242]  C. Breivogel,et al.  Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. , 2000, Journal of neurochemistry.

[243]  G. Kunos,et al.  Mesenteric vasodilation mediated by endothelial anandamide receptors. , 1999, Hypertension.

[244]  V. Di Marzo.  'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. , 1998, Biochimica et biophysica acta.

[245]  S. Bevan,et al.  Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region". , 1993, Journal of medicinal chemistry.

[246]  S. Burstein,et al.  Prostaglandins and cannabis--VI. Release of arachidonic acid from HeLa cells by delta1-tetrahydrocannabinol and other cannabinoids. , 1978, Biochemical pharmacology.