Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor

[1]  K. Browning,et al.  Vagally mediated effects of glucagon‐like peptide 1: in vitro and in vivo gastric actions , 2009, The Journal of physiology.

[2]  H. Hara,et al.  GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[3]  J. Holst,et al.  Receptor‐mediated activation of gastric vagal afferents by glucagon‐like peptide‐1 in the rat , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[4]  L. L. Tan,et al.  Neurochemical and morphological phenotypes of vagal afferent neurons innervating the adult mouse jejunum , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[5]  W. Langhans,et al.  Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. , 2009, Endocrinology.

[6]  H. Grill,et al.  Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. , 2008, Endocrinology.

[7]  T. Moran,et al.  The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[8]  E. Fox,et al.  Anterograde tracing method using DiI to label vagal innervation of the embryonic and early postnatal mouse gastrointestinal tract , 2007, Journal of Neuroscience Methods.

[9]  C. Anderson,et al.  Biological activity of AC3174, a peptide analog of exendin-4 , 2007, Regulatory Peptides.

[10]  M. Schwartz,et al.  Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation , 2006, Diabetes.

[11]  A. Bond Exenatide (Byetta) as a Novel Treatment Option for Type 2 Diabetes Mellitus , 2006, Proceedings.

[12]  A. Young,et al.  Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures , 2006, International Journal of Obesity.

[13]  D. Drucker,et al.  Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice. , 2005, Endocrinology.

[14]  J. Reeve,et al.  Role for the enteric nervous system in the regulation of satiety via cholecystokinin-8. , 2005, Journal of the American Veterinary Medical Association.

[15]  Stephen R. Bloom,et al.  The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway , 2005, Brain Research.

[16]  D. Drucker,et al.  Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. , 2004, Gastroenterology.

[17]  H. Berthoud,et al.  Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[18]  D. Grundy,et al.  What activates visceral afferents? , 2004, Gut.

[19]  T. Kigoshi,et al.  Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells , 2004, Autonomic Neuroscience.

[20]  A. Kastin,et al.  Entry of exendin-4 into brain is rapid but may be limited at high doses , 2003, International Journal of Obesity.

[21]  M. Kakei,et al.  Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons , 2002, Autonomic Neuroscience.

[22]  C. Saper,et al.  Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. , 2002, The Journal of clinical investigation.

[23]  A. Aziz,et al.  Exendin-4, a GLP-1 receptor agonist, modulates the effect of macronutrients on food intake by rats. , 2002, The Journal of nutrition.

[24]  J. Arch,et al.  Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats. , 2000, Obesity research.

[25]  E. Blázquez,et al.  Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats. , 2000, Metabolism: clinical and experimental.

[26]  N. Greig,et al.  Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats. , 2000, Endocrinology.

[27]  J. Holst,et al.  Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. , 1998, Diabetes.

[28]  A. Buchan,et al.  Glucagon-Like-Peptide-1 Secretion from Canine L-Cells Is Increased by Glucose-Dependent-Insulinotropic Peptide but Unaffected by Glucose , 1998 .

[29]  B. Yeğen,et al.  Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. , 1997, American journal of physiology. Gastrointestinal and liver physiology.

[30]  D. Smith,et al.  A role for glucagon-like peptide-1 in the central regulation of feeding , 1996, Nature.

[31]  B. Göke,et al.  Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. , 1993, The Journal of biological chemistry.

[32]  J. Eng,et al.  Actions of Helodermatidae venom peptides and mammalian glucagon-like peptides on gastric chief cells. , 1993, The American journal of physiology.

[33]  J. Raufman,et al.  Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. , 1992, The Journal of biological chemistry.

[34]  John T. Williams,et al.  Ion conductances affected by 5-HT receptor subtypes in mammalian neurons , 1990, Trends in Neurosciences.

[35]  W. Creutzfeldt,et al.  Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets , 1985, Diabetologia.

[36]  Charles Watson,et al.  Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight , 1985, Journal of Neuroscience Methods.

[37]  V. Mutt,et al.  Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum , 1982 .